KALOJI NARAYANA RAO UNIVERSITY OF HEALTH SCIENCES
WARANGAL, TELANGANA STATE ? 506 002
MBBS FIRST YEAR EXAMINATIONS: SEPTEMBER,2025
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PHYSIOLOGYPAPER ? I
Time: 3 Hours
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Max Marks: 100Note: Answer all questions
Give Diagrammatic representation wherever necessary
Multiple Choice Questions:
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10 X 1 = 101. Hering Breuer Reflex protects lung from
a) Circulating Toxins
b) Circulating Phagocytes
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c) Overinflation
d) Under Ventilation
2. Which of the following organs has the greatest blood flow per 100g of tissue?
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a) Brain
b) Skin
c) Kidney
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d) Liver3. The most appropriate index of left ventricular afterload is
a) Systolic arterial pressure
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b) Mean arterial pressurec) Systemic vascular resistance
d) Left ventricular systolic pressure
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4. Major source of ammonia production in renal tubular cell is bya) Deamination of glutamine
b) Deamination of glutamic acid
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c) Deamination of other amino acids, d) Comes directly from arterial bloodglycine, asparagine. alanine
5. Cholerectics are the substances which causes
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a) Contraction of gall bladderb) Increase biliary secretion from liver
c) Neutralization of acid from
d) Solubility of fats in micelles
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stomach
6. First heart sound (HS1):
a) Marks the onset of ventricular
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b) Caused by the closure of semilunarsystole
valves
c) Best heard over aortic and
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d) Characterized by high pitch and sharppulmonary areas
sound
7. The renal " countercurrent" mechanism is dependent upon the anatomic relationship
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between:a) The distal tubule and the macula
b) The loop of Henle and the macula
densa
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densac) The loop of Henle and the vasa
d) The glomerulus and the afferent and
recta
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efferent arterioles8. The adhesion of platelets to subendothelial collagen is impaired in the absence of:
a) Von Willebrand factor
b) Plasmin
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c) Heparin
d) Antithrombin III
9. The function of axonemal dynein is?
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a) Moves particles to the 'minus' end b) Binds to actin and produce motion by
of microtubule.
bending their neck region.
c) Responsible for the beating of
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d) Moves particles towards 'plus' end offlagella and cilia.
microtubule.
10. Cholesterol content of a cell membrane influences which of the following
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characteristics of biological membrane
a) Ion permeability
b) Fluidity
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c) Glycosylationd) Hydrophobicity
Essay/ Long Answer Questions:
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2 X 15 = 30
11. An elderly male came to hospital with history of chest pain and breathing difficulty on and
off for 2 days. His ECG showed ST segment depression and echocardiography showed that
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his stroke volume in <50%.a) Identify the condition.
b) Define stroke volume, cardiac output and cardiac index with their normal value.
c) Describe the factors regulating cardiac output.
d) Define Fick's principle. Mention the methods to measure cardiac output. (1+3+6+5)
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12. A young male went for trekking 2500m above sea level. On arrival to his stay, he complainedof breathlessness. His Spo2 was 70% in room air.
a) Identify the condition.
b) Describe the classification and patho physiology of Hypoxia
c) Enumerate the treatment for the types of Hypoxia
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d) Discuss on Hyperbaric O2 therapy.(1+6+6+2)
Short Answer Questions:
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7 X 6 = 42
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13. Describe the mechanism of HCL secretion in stomach14. Name the different body fluid compartments. Give the composition of extracellular and
intracellular fluids. Mention the methods to measure ECF.
15. Describe Defecation reflex.
16. Classify leukocytes. Describe the stages of leucopoiesis.
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17. Define haemostasis. Describe the extrinsic mechanism of coagulation.18. Enumerate the measures that strengthen the doctor patient relationship.
19. Briefly explain water reabsorption by Kidney.
Very Short Answer Questions:
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6 X 3 = 18
20. Draw a neat labelled diagram of nerve action potential mentioning reasons for each phase.
21. List functions of plasma proteins
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22. Draw a neat labelled diagram of Juxtaglomerular apparatus.23. Define uniport, symport and antiport with examples.
24. Define urea clearance. How is it calculated. Name any other 2 substances used to measure
renal clearance.
25. Write the significance of Dietary fibres.
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