KALOJI NARAYANA RAO UNIVERSITY OF HEALTH SCIENCES
WARANGAL, TELANGANA STATE ? 506 002
MBBS SECOND YEAR DEGREE EXAMINATIONS: JANUARY, 2025
PHARMACOLOGY
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Paper ?ITime: 3 Hours
Max Marks: 100
Note: Answer all questions
Give Diagrammatic representation wherever necessary
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Multiple Choice Questions:10 X 1 = 10
1
Redistribution is a feature of
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a) highly lipid soluble drugsb) poorly lipid soluble drugs
c) depot preparations
d) highly plasma protein bound
drugs
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If the effect of combination of two drugs is equal to or greater than the sum2 of their individual effects, the two drugs are exhibiting:
a) Tachyphylaxis
b) Synergism
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c) Cross toleranced) Antagonism
3
Prolonged lithium therapy can cause:
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a)Diabetes mellitus
b)
Goitre
c)
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Parkinsonismd)
Gout
4
The following are the Orphan drugs Except
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a) Fomepizole
b) Acetyl Cysteine
c) Erythropoietin
d) Flumazenil
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5Which of the following anticholinergic agents is a CNS depressant
a) Atropine
b) Scopolamine
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c) Dicyclomined) Oxyphenonium
6
Alpha 1 Blocker without any effect on blood pressure
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a) Prazosinb) Doxazosin
c) Tamsulosin
d) Terazosin
7
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All of the following are reversible inhibitors of cyclo-oxygenase excepta)
Diclofenac
b)
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Aspirinc)
Ibuprofen
d)
Indomethacin
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8Choose the correct statement below
a) Acidic drugs are largely
b) Basic drugs attain higher
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ionized at acid gastric PHconcentration extracellularly
c) Weakly acidic drugs, ionize
d) Weakly basic drugs ionize more
more at alkaline PH
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at alkaline PH9 Which of the following drug produce extra pyramidal side effect
a)
Metoclopramide
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b) Cisapridec)
Domperidone
d)
All of the above
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10 Directly acting skeletal muscle relaxants isa)
Dantrolene sodium
b)
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Pancuroniumc)
Succinyl choline
d)
Vecuronium
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Essay/ Long Answer Questions:
2 X 15 = 30
11. Classify Sedative Hypnotics. Write in brief the mechanism of action uses,
adverse effects of Benzodiazepines
4+4+4+3 = 15
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12. Classify Beta Blockers. Write in brief their uses and adverse effects add a noteon Cardio Selective Beta Blockers?
4+4+4+3 = 15
Short Answer Questions:
7 X 6 = 42
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13. Explain Drug Synergism with examples.14. What is the first Pass Metabolism? Explain its significance.
15. Explain Pharmacogenetics with examples.
16. Describe the mechanism of action, uses and adverse effects of Carbamazepine.
17. List commonly used NSAIDs. Explain their mechanism of action and common
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adverse effects.18. Describe the pharmacotherapy of status Asthmatics.
19. Describe how to motivate patients with long standing hypertension to adhere to
the prescribed treatment of the physician.
Very Short Answer Questions:
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6 X 3 = 1820. Explain the rationale of using Tamsulosin in Benign Hypertrophy of Prostate
(BHP).
21. List advantages of second generation Antihistaminics over conventional
Antihistaminics.
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22. Name two Mucolytics with indications for their use.23. Name two Antimotility Drugs with indications and contraindications.
24. Explain why Geriatric age group
requires special considerations while
prescribing medications.
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25. What is Eutectic Mixture of Local Anaesthetics (EMLA)? What is its indication?*******