PAPER CODE: MB2019111
KALOJI NARAYANA RAO UNIVERSITY OF HEALTH SCIENCES
WARANGAL, TELANGANA? 506 002
MBBS SECOND YEAR DEGREE SUPPLEMENTARY EXAMINATIONS: JUNE, 2025
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PHARMACOLOGY
Paper ?I
Time: 3 Hours
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Max Marks: 100
Note: Answer all questions
Give Diagrammatic representation wherever necessary
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Multiple Choice Questions: 10 X 1 = 10
1
A prodrug is:
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a) the prototype member of a b) the oldest member of a class of drugs
class of drugs
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c) an inactive drug that isd) that drug stored in body tissues and
transformed in the body to
released gradually in the circulation
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an active metabolite2
The antiasthma drug which cannot be administered by inhalation route is:
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a) Theophyllineb) Ipratropium bromide
c) Budesonide
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d) Terbutaline3
Dissociative anaesthesia' is produced by:
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a) Ketamine
b) Fentanyl
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c) Propofold) Both A & B
4
Which is the most important drug in the treatment of organophosphorus
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poisoning:
a) Atropine sulfate
b) Atenolol
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c) Diazepam
d) Adrenaline
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5Carbamazepine is not used in-
a) Mania
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b) Partial seizurec) Trigeminal neuralgia
d) Migraine
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6
Among the disease modifying anti-rheumatic drugs, fastest symptom relief is
obtained with:
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a) Auranofinb) Hydroxychloroquine
c) Sulfasalazine
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d) Methotrexate7
Drugs having both alpha and beta agonist property
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a) Propranolol
b) Adrenaline
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c) dopamined) Diazepam
8
Which of the following adrenergic agents increases peripheral vascular
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resistance
a) Noradrenaline
b) Adrenaline
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c) Isoprenaline
d) None of the above
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9
Orphan drugs are
a) drugs for rare disease
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b) drugs with high therapeutic failurec) drugs having low
d) drugs with high toxicity
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therapeutic margin
10 Which of the following is used as nasal decongestant
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a) Clonidineb) Dobutamine
c) Norepinephrine
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d) OxymetazolineEssay/ Long Answer Questions:
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2 X 15 = 30
11. a) Define Biotransformation. Describe the consequences of Biotransformation
reactions with examples.
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(2+6)b) Define Enzyme induction and describe its clinical significance.
(2+5)
12. Classify Antiparkinsonian Drugs. Describe the mechanism of action and adverse
effects of Levodopa. Enlist the benefits of combining Levodopa with Carbidopa.
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(6+3+3+3)Short Answer Questions:
7 X 6 = 42
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13. Define apparent Volume of distribution. Describe its clinical significance.14. Compare and contrast Benzodiazepines and Barbiturates.
15. Enlist atropine substitutes and their Therapeutic uses.
16. Describe the drugs used in the treatment of Cough.
17. Explain the mechanism of action, therapeutic uses and adverse effects of
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Ondansetron.18. Enlist Prostaglandin Analogues. Describe their Therapeutics uses.
19. Describe how to motivate patients with coronary artery disease to adhere to the
prescribed treatment of the physician.
Very Short Answer Questions:
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6 X 3 = 18
20. Define Teratogenicity with two examples.
21. Mention the drugs used in the management of Myasthenia Gravis with its rationale.
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22. Enlist any two Inhalational Corticosteroids used in Bronchial Asthma with theiradvantages.
23. Mention three drugs used in generalised Tonic Clonic Seizures.
24. Define Pharmacogenetics. Give two examples.
25. Mention three advantages of using aluminium Hydroxide and Magnesium
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Hydroxide as antacid combination.*****