KALOJI NARAYANA RAO UNIVERSITY OF HEALTH SCIENCES
WARANGAL, TELANGANA STATE ? 506 002
MBBS FIRST YEAR SUPPLEMENTARY EXAMINATIONS: NOVEMBER,2025
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BIOCHEMISTRYPAPER ? I
Time: 3 Hours
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Max Marks: 100
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Note: Answer all questionsGive Diagrammatic representation wherever necessary
Multiple Choice Questions:
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10 X 1 = 10
1.
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Calcitriol acts synergistically with the following hormone on bonea) Calcitonin
b) Epinephrine
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c) Parathyroid hormone (PTH)
d) Insulin
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2.Coenzyme A is derived from which vitamin
a) Thiamine
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b) Pyridoxinec) Cobalamin
d) Pantothenate
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3.
Which one of the following trace element deficiency causes loss
of taste sensation
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a) Copper
b) Iron
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c) Zincd) Selenium
4.
Which of the following nonproteins can act as an enzyme.
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a) DNA
b) RNA
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c) Phospholipid
d) Glycolipid
5.
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Thermogenin is found ina) Thyroid Gland
b) Thymus Gland
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c) Brown Adipose Tissue
d) Adrenal Gland
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6.Anticoagulants used in biochemical tests are
a) Heparin
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b) EDTAc) Potassium or Sodium oxalate d) All of the above
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7.Insulin /Glucagon ratio is high in the
a) Well-fed state
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b) Overnight fastc) Early fasting state
d) All the above
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8.
In the well fed state, all the following pathways are active in the
liver, except
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a) Glycolysis
b) Glucose uptake by
hepatocytes
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c) Gluconeogenesis
d) Glycogenesis
9.
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Earliest Marker of myocardial Infarction isa) Ck1
b) Ck2
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c) Ck3
d) Ck4
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10. Antidote kits for cyanide poisoning contain
a) Amyl nitrate
b) Sodium nitrite
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c) BAL
d) Both A and B
Essay/ Long Answer Questions:
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2 X 15 = 30
11. A 6-year-old was brought to OPD with a history of slow growth and pain in
bones. On examination revealed bow leg deformities; frontal bossing; pigeon
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chest deformities. Laboratory investigations shows:-Serum Calcium = 7.9mg%, Serum Phosphorus = 2.4mg%, Serum alkaline
phosphatase = 690U/L.
a) What is the likely diagnosis?
b) Write in detail about dietary sources, daily requirement, biochemical
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functions, regulation of blood calcium homoeostasis and diseasedconditions of the deficient mineral element.
c) Write the normal levels of the above lab tests in serum. (2+10+3)
12. a) Classify the Enzymes? Giving one example for each.
b) What are factors influencing enzyme activity?
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c) What are the different types of enzyme inhibition. Explain with suitableexamples.
d) Clinical importance of inhibition.
(3+4+4+4)
Short Answer Questions:
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7 X 6 = 4213. Polymerase chain reaction (PCR) and its clinical application. What is
RTPCR?
14. What are the sources of Dietary fibre? Discuss the importance of it in
Nutrition.
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15. Schematic representation of Electron transport chain. Add a note onUncouplers.
16. Describe how physician is important in health care system?
17. Define BMR. What are the factors regulating BMR.
18. Describe in detail on the metabolism of Galactose and add a note on disorders
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of it correlating clinically.19. Outline the Denovo synthesis of fatty acid. What are the advantages of having
a multifunctional enzyme complex?
Very Short Answer Questions:
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6 X 3 = 18
20. Glycated Haemoglobin & its clinical interpretation.
21. Fluid mosaic model of membrane.
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22. Benedict's test.23. Hetero polysaccharides.
24. Write on the classification and characteristics of Hyper and
Hypolipoproteinaemia's.
25. Wernicke ? Korsakoff syndrome.
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