KALOJI NARAYANA RAO UNIVERSITY OF HEALTH SCIENCES
WARANGAL, TELANGANA? 506 002
MBBS FIRST YEAR SUPPLEMENTARY EXAMINATIONS: NOVEMBER, 2024
BIOCHEMISTRY
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PAPER ? IITime: 3 Hours
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Max Marks: 100
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Note: Answer all questionsGive Diagrammatic representation wherever necessary
Multiple Choice Questions:
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10 X 1 = 10
1.
Name the defective enzyme in maple syrup urine disease (Branched
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Chain Ketonuria)
a)
Cystathionine
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b) Phenyl alanine hydroxylasec)
Homogentisic acid oxidase
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d) Oxidative decarboxylase2.
Increased gastric HCI secretion is found in
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a)
Zollinger- Ellison syndrome b) Gastric carcinoma
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c)Pernicious anemia
d) Gastritis
3.
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The serum enzyme used to evaluate pancreatic function isa)
Acid phosphtase
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b) Amylasec)
Alkaline phosphatase
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d) Lactate dehydrogenase4.
Which of the following enzymes are involved in
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Biotransformation?a)
Transaminases
b) Cytochrome P450 enzymes
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c)
Dehydrogenases
d) Decarboxylases
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5.
Which one of the following enzymes is not a protein, but an RNA
molecule
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a)Amylase
b) RNA polymerase
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c)Urokinase
d) Reverse transcriptase
6.
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An amino acid not found in proteins isa)
Homocysteine
b) Proline
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c)
Lysine
d) Histidine
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7.
Following are the beneficial effect of Reactive Oxygen Species
(ROS), except
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a)
Bactericidal effect
b) Reduces blood pressure
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c)
radiotherapy
d) Mutations
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8.The most abundant protein in mammals is
a)
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Albuminb) Globulins
c)
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Collagend) Elastin
9.
Which of the following is not a biologically important peptide.
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a)
Glutathione
b) Angiotensin
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c)
Vasopressin
d) leukotriene
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10.
Which one of the following enzyme acts as biomarker in the
diagnosis of prostate cancer
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a)Amylase
b) AST
c)
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Acid phosphatased) Alkaline phosphatase
Write an essay on the following:
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2 X 15 = 30
11. A 16-year old boy who was given blood transfusion recently had presented with
chills and rigors of 2 days duration. Laboratory investigations revealed the
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following findings:Serum total bilirubin: 4.8 mg/dL, Serum conjugated bilirubin : 0.2 mg/dL,
Urine Bilirubin: Negative, Van den Bergh reaction is indirect positive.
a) What is the probable diagnosis?
b) How do you relate the history and laboratory findings to confirm your
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diagnosis? (Use flow chart to explain if required)c) Describe normal bilirubin metabolism.
d) Name the test performed to identify presence of bile pigments in the urine.
(1+4+8+2)
12. Explain the structure of DNA under the following headings:
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a) Using a neat a labelled diagram explain the structural organization of DNA.b) Name the histone proteins.
c) Compare and contrast the differences between DNA and RNA.
d) Name the different forms of DNA.
(8+2+3+2)
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Write a short essay on the following:7 X 6 = 42
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13. Name the different levels of the structural organization or proteins. Discuss thesecondary structure of proteins and add a note on the bonds responsible for
stabilizing the secondary structure.
14. Write the compounds derived from glycine and their importance
15. Explain how learning influence the Physician Growth.
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16. What are tumor markers? Discuss the clinical utility of any three tumor markers.17. Describe in detail the glomerular function tests. Add a note on the formulae
available for calculating estimated glomerular function rate (eGFR).
18. Describe the structure of normal haemoglobin molecule. Add a note on
Thalassemia.
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19. Explain with diagram the structure of IgG molecule and indicate its bindingsites and function of IgG.
Write briefly on the following:
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6 X 3 = 18
20. Name the plasma proteins. Write the functions of serum albumin.
21. Operon Concept.
22. Name the thyroid function tests. Write the reference range for T4 and TSH.
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23. Post translational modifications.24. Phase I detoxification reactions.
25. Alkali reserve.
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