KALOJI NARAYANA RAO UNIVERSITY OF HEALTH SCIENCES
WARANGAL, TELANGANA STATE ? 506 002
MBBS FIRST YEAR SUPPLEMENTARY EXAMINATIONS: NOVEMBER,2025
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BIOCHEMISTRYPAPER ? II
Time: 3 Hours
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Max Marks: 100Note: Answer all questions
Give Diagrammatic representation wherever necessary
Multiple Choice Questions:
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10 X 1 = 10
1. One of the following vitamins is associated with purine synthesis
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a) Folate
b) Biotin
c) Pyridoxine
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d) Vitamin B122. Vanden Bergh reaction is indirect positive in which jaundice
a) Hepatocellular
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b) Hemolyticc) Obstructive
d) All of the above
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3. Following are the tests used to assess the gastric function ,excepta) Pentagastrin stimulation test
b) Alcohol test meal
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c) Urea clearanced) Insulin test meal
4. All of the following porphyrias are inherited as autosomal dominant, except
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a) Porphyria cutana tardab) Congenital erythropoietic porphyria
c) Protoporphyria
d) Acute intermittent porphyria
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5. The substance that facilitates the release of oxygen from oxyhemoglobin to the tissues
a) H+ ion
b) CI-- ions
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c) 2,3 --Bisphospho glycerated) Glucose
6. Endocrine gland that is associated with the regulation of BMR
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a) Pituitaryb) Thyroid
c) Adrenal
d) Endocrine part of pancreas
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7. Which one of the following is a cancer suppressor gene
a) sis
b) ras
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c) erb-B
d) p53
8. The factories of protein biosynthesis is
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a) Nucleus
b) Ribosomes
c) Mitochondrion
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d) Cell sap9. Regan isoenzyme is increased in
a) Lung cancer
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b) Osteoporosisc) Paget's disease
d) Myocardial infarction
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10. The principal cation in intracellular fluid is
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a) Sodium
b) Potassium
c) Calcium
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d) MagnesiumEssay/ Long Answer Questions:
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2 X 15 = 3011. A 6-month-old infant began to vomit occasionally and ceased to gain weight at 9
months of the age. He was readmitted to the hospital. After one week he became
drowsy had fever, pulse was elevated and there was hepatomegaly. EEG was done and
was grossly abnormal.
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Blood ammonia was elevated and urine contained high amount of glutamine and uracila) What is probable diagnosis?
b) What is pathogenic mechanism involved?
c) Describe how ammonia of aminoacid is metabolised?
d) What is the normal plasma concentration of ammonia? (2+5+7+1)
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12. What are the types of DNA repair and name the diseases caused by various mutations.Short Answer Questions:
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7 X 6 = 42
13. Structural organization levels of Proteins.
14. Mention the different types of tumour markers. Describe the significance of any three
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tumour markers.15. Salvage pathway of Purine synthesis and add a note on Lesch Nyhan syndrome.
16. Discuss the Renal mechanisms involved in regulation of blood pH.
17. Define detoxification. Write in detail on the phases of detoxification and mention
examples clinically related where ever necessary.
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18. Degradation of Haemoglobin.19. Explain the commitment to lifelong learning is related to physician growth.
Very Short Answer Questions:
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6 X 3 = 18
20. Synthetic Nucleotides.
21. Autoimmunity.
22. Hartnup`s disease.
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23. Calculate the anion gap using the following data: serum Sodium: 145 mmol/L, Serumpotassium; 4.0mmol/L, Serum bicarbonate ? 24mmol/L, serum chloride: 104 mmol/L.
24. Genetic code.
25. Explain Chloride shift.
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