2019 Scheme
Q.P. Code: 211001
Reg. no.: .....................
Second Professional MBBS Degree Regular/Supplementary Examinations
August 2025
(General Pharmacology, ANS, CNS, CVS, Blood, Diuretics, Autacoids, Respiratory System)
Time: 3 Hours
Total Marks: 100
Answer all questions to the point neatly and legibly ? Do not leave any blank pages between answers
Answer all parts of a single question together ? Leave sufficient space between answers
Draw table/diagrams/flow charts wherever necessary
1. Multiple Choice Questions
(20x1=20)
answering MCQ questions at page No. 51 of the answer book (the inner portion of the back cover
page (PART III)). Responses for MCQs marked in any other part/page of the answer book will not
be valued
Question Numbers i ? v are Single Response Type
a) Hydrocortisone
b) Theophylline
c) Phenobarbitone
d) Pindolol
a) Pindolol
b) Carvedilol
c) Bisoprolol
d) Timolol
a) Atogepant
b) Ubrogepant
c) Zavegepant
d) Rimegepant
a) Nalbuphine
b) Nalorphine
c) Naloxone
d) Buprenorphine
a) Nicorandil
b) Amlodipine
c) Ranolazine
d) Ivabradine
appropriately.
vi. Which of the following are used as Mucolytics
1) Acebrophylline
2) Theophylline
4) Acetyl cysteine
a) 1 & 2 are correct
b) 2 & 3 are correct c) 3 & 4 are correct
d) 1 & 4 are correct
1) Primidone
2) Piracetam
3) Memantine
4) Rufinamide
d) 1 & 4 are correct
viii. Direct Thrombin Inhibitor given parenterally
1) Rivaroxaban
2) Bivalirudin
4) Edoxaban
a) 1 & 2 are correct b) 2 & 3 are correct c) 3 & 4 are correct
d) 1 & 4 are correct
ix. Acetazolamide is used in the following conditions
2) Heart failure
3) Absence Epilepsy
4) Glaucoma
a) 1 & 2 are correct b) 2 & 3 are correct c) 3 & 4 are correct
x. Following drugs are highly bound to plasma protein albumin
1) Phenytoin
2) Warfarin
3) Prazosin
a) 1 & 2 are correct b) 2 & 3 are correct c) 3 & 4 are correct
d) 1 & 4 are correct
Question Numbers xi ? xv are based on case scenarios. Read the statements and mark the
answers accordingly.
behaviour. He has accused several fellow students and professors of spying on him. He has stopped
bathing and will only change his clothes once a week. In your office you find him with acute psychosis
likely secondary to Schizophrenia, admit him to the psychiatric unit of the hospital and start him on
Haloperidol
a) Alpha 2
b) D2
c) Beta 1
d) D1
a) Clozapine
b) Chlorpromazine
c) Thioridazine
d) Haloperidol
which of the following adverse effect
a) Akathisia
b) Orthostatic hypotension c) Sedation
d) Urinary retention
xiv. Exacerbation of new onset of Diabetes is more frequent with
a) Haloperidol
b) Chlorpromazine
c) Quetiapine
xv. Following antipsychotic drug has weak D 2 blocking action, but additional 5-HT2 blocking activity and
benefits both positive and negative symptoms of Schizophrenia
a) Loxapine
b) Clozapine
d) Penfluridol
Question numbers xvi ? xx consists of statements ? Assertion (A) and Reason (R). Answer these
questions by selecting the appropriate options given below.
a) Both A & R are true and R is the correct explanation
b) Both A & R are true and R is not the correct explanation d) A is false but R is true
xvi. Assertion: Gastric toxicity is the major consideration in the use of NSAIDs
Reason: NSAIDs cause inhibition of COX-1 mediated synthesis of gastroprotective Prostaglandins
xvii. Assertion: Entacapone is useful in the treatment drug induced Parkinsonism
Levodopa to enter the brain
xviii. Assertion: Genetically determined reaction Malignant Hyperthermia is produced by Halothane
Reason: Susceptible subjects have an abnormal Ryanodine receptor 1 Calcium channel at the
sarcoplasmic reticulum which is triggered by Halothane, cause massive release of calcium leading to
xix. Assertion: Older antihistaminics produce dryness of mouth, urinary hesitancy and blurring of vision
Reason: Older antihistaminics have anticholinesterase property
xx. Assertion: Vitamin K is the specific antidote for Heparin induced bleeding
Reason: Vitamin K helps in the resynthesis and release of Vitamin K dependent clotting factors
(2x10=20)
2. Define Biotransformation. What are the various phases of Biotransformation. Add a detailed note on
factors affecting drug action
(2+3+5)
similar discomfort while climbing stairs, which relieved on taking rest. On examination his BP was
152/86 mm of Hg and pulse rate was 88/minute. He gives history of sudden cardiac deaths in his
family
a) How will you treat this patient, a case of Angina pectoris
c) Explain in detail the mechanism of action and adverse effects of Nitrates
d) Which all drugs can be given as prophylaxis
(2+3+3+2)
Short Essays:
4. What are the clinical manifestations of Methanol poisoning. How will you manage the patient (2+4)
5. Classify drugs used in treatment of congestive cardiac failure. Discuss the role of diuretics in heart
failure
(4+2)
complications of Spinal anaesthesia
(2+4)
7. Discuss the role of Inhalational Steroids in the management of Bronchial Asthma. How will you
manage a patient with Status Asthmaticus
8. What is Chronic Gout. What is the role of Uric acid synthesis inhibitors in the management
of Chronic Gout
(1+5)
9. Enumerate the Alpha 1 selective adrenergic blockers. Discuss their indications for use and adverse
(2+2+2)
Short Answers:
(6x4=24)
10. Define Bioavailability. What are the various factors affecting Bioavailability
12. Discuss the Pharmacotherapy of Myasthenia Gravis
13. Describe the various drugs used in treatment and prophylaxis of Migraine
14. Enumerate the drugs used as Pre anaesthetic medication with the rationale for use of each
15. Discuss the types of communication and its importance
Q.P. Code: 211001
Reg. no.: .....................
Second Professional MBBS Degree Regular/Supplementary Examinations
August 2025
--- Content provided by FirstRanker.com ---
Pharmacology - Paper I(General Pharmacology, ANS, CNS, CVS, Blood, Diuretics, Autacoids, Respiratory System)
Time: 3 Hours
Total Marks: 100
Answer all questions to the point neatly and legibly ? Do not leave any blank pages between answers
--- Content provided by FirstRanker.com ---
Indicate the question number correctly for the answer in the margin spaceAnswer all parts of a single question together ? Leave sufficient space between answers
Draw table/diagrams/flow charts wherever necessary
1. Multiple Choice Questions
(20x1=20)
--- Content provided by FirstRanker.com ---
The responses for MCQ questions (Q.No. i to Q.No. xx) shall be written in the space provided foranswering MCQ questions at page No. 51 of the answer book (the inner portion of the back cover
page (PART III)). Responses for MCQs marked in any other part/page of the answer book will not
be valued
Question Numbers i ? v are Single Response Type
--- Content provided by FirstRanker.com ---
i. Drug which is not given orally because of having a high first pass metabolisma) Hydrocortisone
b) Theophylline
c) Phenobarbitone
d) Pindolol
--- Content provided by FirstRanker.com ---
ii. Beta blocker with additional alpha blocking activitya) Pindolol
b) Carvedilol
c) Bisoprolol
d) Timolol
--- Content provided by FirstRanker.com ---
iii. First CGRP receptor antagonist approved by US-FDA for treatment of Acute Migrainea) Atogepant
b) Ubrogepant
c) Zavegepant
d) Rimegepant
--- Content provided by FirstRanker.com ---
iv. Pure opioid antagonist used for the treatment of Morphine poisoninga) Nalbuphine
b) Nalorphine
c) Naloxone
d) Buprenorphine
--- Content provided by FirstRanker.com ---
v. Potassium channel opener used as an Antianginal agenta) Nicorandil
b) Amlodipine
c) Ranolazine
d) Ivabradine
--- Content provided by FirstRanker.com ---
Question Numbers vi ? x are Multiple Response Type. Read the statements and mark the answersappropriately.
vi. Which of the following are used as Mucolytics
1) Acebrophylline
2) Theophylline
--- Content provided by FirstRanker.com ---
3) Dextromethorphan4) Acetyl cysteine
a) 1 & 2 are correct
b) 2 & 3 are correct c) 3 & 4 are correct
d) 1 & 4 are correct
--- Content provided by FirstRanker.com ---
vii. Cognition enhancers used in Alzheimer's Disease1) Primidone
2) Piracetam
3) Memantine
4) Rufinamide
--- Content provided by FirstRanker.com ---
a) 1 & 2 are correct b) 2 & 3 are correct c) 3 & 4 are correctd) 1 & 4 are correct
viii. Direct Thrombin Inhibitor given parenterally
1) Rivaroxaban
2) Bivalirudin
--- Content provided by FirstRanker.com ---
3) Argatroban4) Edoxaban
a) 1 & 2 are correct b) 2 & 3 are correct c) 3 & 4 are correct
d) 1 & 4 are correct
ix. Acetazolamide is used in the following conditions
--- Content provided by FirstRanker.com ---
1) Hypertension2) Heart failure
3) Absence Epilepsy
4) Glaucoma
a) 1 & 2 are correct b) 2 & 3 are correct c) 3 & 4 are correct
--- Content provided by FirstRanker.com ---
d) 1 & 4 are correctx. Following drugs are highly bound to plasma protein albumin
1) Phenytoin
2) Warfarin
3) Prazosin
--- Content provided by FirstRanker.com ---
4) Bupivacainea) 1 & 2 are correct b) 2 & 3 are correct c) 3 & 4 are correct
d) 1 & 4 are correct
Question Numbers xi ? xv are based on case scenarios. Read the statements and mark the
answers accordingly.
--- Content provided by FirstRanker.com ---
A 19-year old man is brought to the physician's office by his very concerned mother for his "bizarre'behaviour. He has accused several fellow students and professors of spying on him. He has stopped
bathing and will only change his clothes once a week. In your office you find him with acute psychosis
likely secondary to Schizophrenia, admit him to the psychiatric unit of the hospital and start him on
Haloperidol
--- Content provided by FirstRanker.com ---
xi. Haloperidol is potent antagonist of receptora) Alpha 2
b) D2
c) Beta 1
d) D1
--- Content provided by FirstRanker.com ---
xii. Which of the following is an atypical antipsychotica) Clozapine
b) Chlorpromazine
c) Thioridazine
d) Haloperidol
--- Content provided by FirstRanker.com ---
xiii. Compared to the low potency phenothiazine antipsychotic agents, haloperidol is more likely to causewhich of the following adverse effect
a) Akathisia
b) Orthostatic hypotension c) Sedation
d) Urinary retention
--- Content provided by FirstRanker.com ---
(PTO)xiv. Exacerbation of new onset of Diabetes is more frequent with
a) Haloperidol
b) Chlorpromazine
c) Quetiapine
--- Content provided by FirstRanker.com ---
d) Aripiprazolexv. Following antipsychotic drug has weak D 2 blocking action, but additional 5-HT2 blocking activity and
benefits both positive and negative symptoms of Schizophrenia
a) Loxapine
b) Clozapine
--- Content provided by FirstRanker.com ---
c) Pimozided) Penfluridol
Question numbers xvi ? xx consists of statements ? Assertion (A) and Reason (R). Answer these
questions by selecting the appropriate options given below.
a) Both A & R are true and R is the correct explanation
--- Content provided by FirstRanker.com ---
c) A is true but R is falseb) Both A & R are true and R is not the correct explanation d) A is false but R is true
xvi. Assertion: Gastric toxicity is the major consideration in the use of NSAIDs
Reason: NSAIDs cause inhibition of COX-1 mediated synthesis of gastroprotective Prostaglandins
xvii. Assertion: Entacapone is useful in the treatment drug induced Parkinsonism
--- Content provided by FirstRanker.com ---
Reason: By inhibiting the metabolism of levodopa by COMT, entacapone allows a larger fraction ofLevodopa to enter the brain
xviii. Assertion: Genetically determined reaction Malignant Hyperthermia is produced by Halothane
Reason: Susceptible subjects have an abnormal Ryanodine receptor 1 Calcium channel at the
sarcoplasmic reticulum which is triggered by Halothane, cause massive release of calcium leading to
--- Content provided by FirstRanker.com ---
muscle contraction and heat productionxix. Assertion: Older antihistaminics produce dryness of mouth, urinary hesitancy and blurring of vision
Reason: Older antihistaminics have anticholinesterase property
xx. Assertion: Vitamin K is the specific antidote for Heparin induced bleeding
Reason: Vitamin K helps in the resynthesis and release of Vitamin K dependent clotting factors
--- Content provided by FirstRanker.com ---
Long Essays:(2x10=20)
2. Define Biotransformation. What are the various phases of Biotransformation. Add a detailed note on
factors affecting drug action
(2+3+5)
--- Content provided by FirstRanker.com ---
3. A 60-year-old man came to casuality with complaints of heaviness in chest. He gives a history ofsimilar discomfort while climbing stairs, which relieved on taking rest. On examination his BP was
152/86 mm of Hg and pulse rate was 88/minute. He gives history of sudden cardiac deaths in his
family
a) How will you treat this patient, a case of Angina pectoris
--- Content provided by FirstRanker.com ---
b) Classify Antianginal drugsc) Explain in detail the mechanism of action and adverse effects of Nitrates
d) Which all drugs can be given as prophylaxis
(2+3+3+2)
Short Essays:
--- Content provided by FirstRanker.com ---
(6x6=36)4. What are the clinical manifestations of Methanol poisoning. How will you manage the patient (2+4)
5. Classify drugs used in treatment of congestive cardiac failure. Discuss the role of diuretics in heart
failure
(4+2)
--- Content provided by FirstRanker.com ---
6. Discuss the mechanism of action of local anaesthetics. Discuss in detail about the variouscomplications of Spinal anaesthesia
(2+4)
7. Discuss the role of Inhalational Steroids in the management of Bronchial Asthma. How will you
manage a patient with Status Asthmaticus
--- Content provided by FirstRanker.com ---
(3+3)8. What is Chronic Gout. What is the role of Uric acid synthesis inhibitors in the management
of Chronic Gout
(1+5)
9. Enumerate the Alpha 1 selective adrenergic blockers. Discuss their indications for use and adverse
--- Content provided by FirstRanker.com ---
effects.(2+2+2)
Short Answers:
(6x4=24)
10. Define Bioavailability. What are the various factors affecting Bioavailability
--- Content provided by FirstRanker.com ---
11. Write the pharmacological actions, uses, adverse effects and contra indications of Morphine12. Discuss the Pharmacotherapy of Myasthenia Gravis
13. Describe the various drugs used in treatment and prophylaxis of Migraine
14. Enumerate the drugs used as Pre anaesthetic medication with the rationale for use of each
15. Discuss the types of communication and its importance
--- Content provided by FirstRanker.com ---
**********************