Download KUHS MBBS 2nd Year 211001 Pharmacology Paper I March 2025 Question Paper

2019 Scheme
Q.P. Code: 211001
Reg. no.: .....................
Second Professional MBBS Degree Supplementary (SAY) Examinations
March 2025

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Pharmacology - Paper I
(General Pharmacology, ANS, CNS, CVS, Blood, Diuretics, Autacoids, Respiratory System)
Time: 3 Hours
Total Marks: 100
Answer all questions to the point neatly and legibly ? Do not leave any blank pages between answers

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Indicate the question number correctly for the answer in the margin space
Answer all parts of a single question together ? Leave sufficient space between answers
Draw table/diagrams/flow charts wherever necessary
1. Multiple Choice Questions
(1x20=20)

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The MCQ questions (Q.No. i to Q.No. xx) shall be written in the space provided for answering
MCQ questions at page No. 51 of the answer book (the inner portion of the back cover page
(PART III)). Responses for MCQs marked in any other part/page of the answer book will not be
valued
Question Numbers i ? v are Single Response Type

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i. The anticoagulant of choice in pregnancy is:
a) Heparin
b) Warfarin c) Dicumarol
d) Phenindione
ii. The diuretic employed in refractory edema resistant to thiazide/loop diuretics is:

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a) Amiloride
b) Acetazolamide c) Mannitol
d) Spironolactone
iii. The medication preferred in the treatment of drug-induced parkinsonism is
a) Ropinirole

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b) Carbidopa
c) Selegiline
d) Trihexyphenidyl
iv. The antihistaminic drug banned due to the deaths caused by Torsades de pointes is
a) Terfenadine

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b) Rupatadine
c) Mizolastine
d) Cetirizine
v. The Vasicoselective anticholinergic used in urinary frequency, urgency, and dysuria is
a) Tacrine

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b) Donepezil
c) Flavoxate
d) Galantamine
Question Numbers vi ? x are Multiple Response Type. Read the statements and mark the answers
appropriately.

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vi. Which of the following drugs can cause QT prolongation
1) Amiodarone
2) Doxorubicin
3) Ibuprofen
4) Erythromycin

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a) 1 & 4 are correct
b) 3 & 4 are correct
c) 1 & 3 are correct d) 2 & 4 are correct
vii. The adrenergic antagonists used to treat benign prostatic hyperplasia (BPH) are:
1) Tamsulosin

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2) Doxazosin 3) Clonidine 4) Metoprolol
a) 3 & 4 are correct
b) 1 & 2 are correct c) 2 & 4 are correct d) 1 & 3 are correct
viii. The Dopamine agonists used to treat Parkinson's disease are:
1) Levodopa

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2) Donepezil 3) Pramipexole
4) Selegiline
a)1 & 2 are correct b) 3 & 4 are correct c) 2 & 4 are correct d) 1 & 3 are correct
ix. Which of the following diuretics are used to treat hyperaldosteronism
1) Chlorthalidone

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2) Eplerenone 3) Furosemide 4) Spironolactone
a) 1 & 2 are correct b) 3 & 4 are correct c) 2 & 4 are correct d) 1 & 3 are correct
x. The direct oral anticoagulants (DOACs) that inhibit factor Xa are
1) Rivaroxaban
2) Apixaban 3) Warfarin 4) Dabigatran

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a) 1 & 2 are correct b) 3 & 4 are correct c) 2 & 4 are correct d) 1 & 3 are correct
Question Numbers xi ? xv are based on case scenarios. Read the statements and mark the
answers accordingly.
Patient: Mrs. Rose, a 68-year-old woman, Chief Complaint: Gradual loss of vision in both eyes, particularly
in the peripheral vision. Medical History: Hypertension, Type 2 Diabetes, and Hyperlipidaemia. No known

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drug allergies. Family History: Her father had glaucoma. Presenting Symptoms: Mrs. Rose reports
difficulty seeing objects in her peripheral vision for the past 6 months. She has had a gradual decrease in
her night vision as well. Ophthalmologic Exam: Intraocular pressure (IOP): 28 mmHg in both eyes Visual
field: Decreased peripheral vision, with a loss in the superior field. Optic disc: Cupping noted in both eyes.
Diagnosis: Open-angle glaucoma.

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xi. The preferred first-line pharmacologic treatment for open-angle glaucoma is:
a) Pilocarpine
b) Latanoprost
c) Brimonidine
d) Acetazolamide

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xii. Mrs. Rose's intraocular pressure (IOP) is 28 mmHg. Which class of drugs is most likely to lower IOP
by decreasing aqueous humour production
a) Beta-blockers
c) Carbonic anhydrase inhibitors
b) Prostaglandin analogues

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d) Alpha-2 adrenergic agonists
(PTO)

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xiii. Which of the following is a potential side effect of the use of prostaglandin analogues like latanoprost
a) Blurring of vision
b) Hypokalemia
c) Mydriasis (dilated pupils) d) Tachycardia
xiv. The drug that should be used cautiously in Mrs. Rose, who has a history of bronchial asthma

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a) Latanoprost
b) Brimonidine
c) Timolol
d) Acetazolamide
xv. Which is the diuretic of choice in treatment of acute congestive glaucoma

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a) Furosemide
b) Hydrochlorothiazide
c) Mannitol
d) Spironolactone
Question numbers xvi ? xx consists of statements ? Assertion (A) and Reason (R). Answer these

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questions by selecting the appropriate options given below.
xvi. Assertion (A): Aspirin is used for its antiplatelet effects to prevent blood clots.
Reason (R): Aspirin inhibits the enzyme cyclooxygenase (COX), which decreases thromboxane A2
production, a molecule that promotes platelet aggregation.
a) Both A and R are true, and R is the correct explanation of A

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c) A is true but R is false
b) Both A and R are true, and R is not the correct explanation of A
d) A is false but R is true
xvii. Assertion (A): Quinidine can cause QT prolongation.
Reason (R): Class IA drugs have maximum sodium channel blocking effect.

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a) Both A and R are true, and R is the correct explanation of A
c) A is true but R is false
b) Both A and R are true, and R is not the correct explanation of A
d) A is false but R is true
xviii. Assertion (A): Allopurinol can precipitate acute gout.

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Reason (R): Inhibition of uric acid synthesis mobilizes tissue store of uric acid in to plasma.
a) Both A and R are true, and R is the correct explanation of A
c) A is true but R is false
b) Both A and R are true, and R is not the correct explanation of A
d) A is false but R is true

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xix. Assertion (A): Pralidoxime is most specific drug for organophosphate poisoning.
Reason (R): Organophosphates block AChE enzyme
a) Both A and R are true, and R is the correct explanation of A
c) A is true but R is false
b) Both A and R are true, and R is not the correct explanation of A

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d) A is false but R is true
xx. Assertion (A): Beta-2 agonists, such as salbutamol, are used to treat asthma.
Reason (R): Beta-2 agonists work by stimulating beta-2 adrenergic receptors on bronchial smooth
muscles, causing bronchodilation.
a) Both A and R are true, and R is the correct explanation of A

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c) A is true but R is false
b) Both A and R are true, and R is not the correct explanation of A
d) A is false but R is true
Long Essays:
(2x10=20)

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2. Define Pharmacodynamics. Explain the various factors modifying drug action with examples. (2+8)
3. A 55-year-old male patient was recently diagnosed as suffering from hepatocellular carcinoma with
metastases to bone. He complains of severe, excruciating pain in the abdomen and spine. He has
complained of sleeplessness and mood swings for the past one month. The oncologist prescribes him
an opioid analgesic drug to relieve his pain and also induce sleep and reduce apprehension of pain.

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a) Classify opioid analgesics.
b) Explain the Mechanism of action of Morphine and its pharmacological actions.
c) Enumerate any THREE clinical uses and adverse effects of Morphine.
(3+4+3)
Short Essays:

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(6x6=36)
4. Discuss in detail about FOUR pharmacokinetic drug interactions with suitable examples.
5. Enumerate the iron preparations and add a note on the indications of parenteral iron therapy. (3+3)
6. Classify general anaesthetics - four groups with two examples. Add a brief note on pre anaesthetic
medication

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(4+2)
7. After injecting succinylcholine I.V. to have muscle relaxation during a surgical procedure, a patient
developed prolonged apnoea. What could be the probable cause. What is the management for the
above condition.
(2+4)

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8. Classify the drugs used in Gout. Explain the mechanism of action and adverse effects of Allopurinol.
(2+4)
9. Classify drugs used in hypertension with TWO examples each. Briefly describe any one group with its
mechanism of action, uses and adverse effects
(4+2)

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Short Answers:
(6x4=24)
10. Explain the rationale of Levodopa and Carbidopa fixed drug combination in Parkinson's disease
11. Enumerate the Merits and Demerits of selective Cox-2 Inhibitors
12. Briefly describe the mechanism of action, uses and adverse effects of sodium valproate.

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13. Briefly describe kinetics of elimination.
14. Explain the adverse effects and role of inhaled steroids in Bronchial asthma.
15. Discuss the types of communication and its importance in Health care settings.
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