Download KUHS MBBS 2nd Year 212001 Pharmacology Paper II Aug 2025 Question Paper

2019 Scheme
Q.P. Code: 212001
Reg. no.: .....................
Second Professional MBBS Degree Regular/Supplementary Examinations

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August 202
5
Pharmacology
- Paper II

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(GIT, Hormones, Antibiotics, Chemotherapy and Miscellaneous
)
Time: 3 Hour
s
Total Marks: 10

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0
Answer all questions to the point neatly and legibly ? Do not leave any blank pages between answers
Indicate the question number correctly for the answer in the margin spac
e
Answer all parts of a single question together ? Leave sufficient space between answers

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Draw table/diagrams/flow charts wherever necessar
y

1. Multiple Choice Question
s

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(20x1=20
)
The responses for MCQ questions (Q.No. i to Q.No. xx) shall be written in the space provided for
answering MCQ questions at page No. 51 of the answer book (the inner portion of the back cover
page (PART III)). Responses for MCQs marked in any other part/page of the answer book will not be

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value
d
Question Numbers i ? v are Single Response Typ
e
i. Which of the following drug is a SERM usefu

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l for treatment of Osteoporosis
a) Raloxifen
b) Bisphosphonates
c) Strontium
d) Estradiol

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ii. Failure of oral contraceptives occur when used with any of these except
a) Aspirin
b) Tetracycline
c) Phenytoin
d) Rifampicin

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iii. The antithyroid drug with the most rapid onset of antithyroid action is
a) I 13
1
b) Sodium iodide
c) Methimazole

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d) Propylthiouracil
iv
. Which of the following drugs promote release of endogenous Insulin
a) Acarbose
b) Glipizide

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c) Metformin
d) Pioglitazone
v. Which of the following disorder is NOT aggrevated by corticosteroid therapy
a) Congenital adrenal hyperplasia
c) Hypertension

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b) Diabetes Mellitus
d) Peptic Ulcer
Question Numbers v
i ? x are Multiple Response Type. Read the statements and mark the answers
appropriately.

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vi
. Which of the following are true about Insulin Lispro
1) Action is faster and shorter in duration than regular Insulin.
2) It is given fifteen minutes prior to meals.
3) Source is Lamb

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.
4) Action is faster and of longer duration than regular Insulin.
a) 1 & 2 are correct
b) 2 & 3 are corre
ct c) 3 & 4 are corre

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ct
d) 4 & 5 are corre
ct
vii. Ototoxicity of aminoglycoside is Increased with concurrent use of which of the following
1) Azithrmycin

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2) Vancomycin
3) Furosemide
4) Ciprofloxacin
a) 1 & 2 are correct
b) 1 & 3 are corre

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ct c) 3 & 4 are corre
ct
d) 2 & 3 are corre
ct
viii. Which o

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f the following drugs are usefu
l for treatment of Anaerobic infection
1) Metronidazole
2) Aztreonam
3) Imipenem

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4) Clotrimazole
a) 1 & 2 are corre
ct b) 1 & 3 are corre
ct c) 2 & 3 are corre
ct

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d) 3 & 4 are corre
ct
ix. Which of the following are the complications of Zidovudine therap
y
1) Anaemia

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2) Hepatotoxicity
3) Nephrotoxicity
4) Cardiotoxicity
a) 1 & 2 are correct
b) 1 & 3 are corre

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ct c) 1 & 4 are corre
ct
d) 2 & 3 are corre
ct
x. Which of the following are Alkylating agents

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1) Cyclophosphamide 2) Paclitaxe
l
3) Busulfan
4) Vincristine
a) 1 & 2 are correct

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b) 2 & 4 are correct
c) 1 & 3 are corre
ct d) 2 & 3 are corre
ct
Question Numbers xi ? xv are based on case scenarios. Read the statements and mark the

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answers accordingly.
A 26 year old female with a two week history of urinary urgency and frequency presents to her primary
care physician for evaluation. Urine analysis reveals urinary tract infection and appropriate antibiotic
was prescribe
d

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xi. Which of the following can be prescribed empirically
a) Ciprofloxacin
b) Gentamicin
c) Tetracycline
d) Procaine penicillin

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xii. Which of the following is a Broad Spectrum antibiotc
a) Erythromycin
b) Amikacin
c) Methicillin
d) Tetracycline

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(PTO)

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xiii.
Which of the following is given for prophylaxis of lower UTI
a) Amoxicillin

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b) Doxycyclin
c) Norfloxaccin
d) Gentamicin
xiv
. The drug inhibiting DNA gyrase is

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a) Azithromycin b) Ciprofloxacin c) Doxycycline
d) Amoxicillin
xv
. Which of the following drug causes Nephrotoxicity
a) Gentamicin

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b) Erythromycin
c) Azithromycin
d) Ofloxacin
Question numbers xvi ? xx consists of statements ? Assertion (A) and Reason (R). Answer these
questions by selecting the appropriate options given below.

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a) Both A and R are true and R is correct explanation of
A

c) A is true and R is false
b) Both A and R are true and R is not the correct explanation of A d) Both A and R are false

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xvi
. Assertion: Finasteride is used for rapid control of urinary symptoms in a patient with prostatic
hyperplasia
Reason: It is an androgen receptor antagonist
xvii. Assertion: Progesterone is added to estrogens in hormone replacement therapy

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Reason: It decrease the risk of endometrial carcinoma
xviii. Assertion: Neomycin can be used orally for gut sterilization in a patient with hepatic coma
Reason: It has very good oral bio-availability
xix. Assertion: Pyridoxine is commonly added to antitubercular regimen
Reason: Isoniazid competitively inhibits pyridoxal kinase

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xx. Assertion: Dexrazoxane is added to doxorubicin containing anticancer therapy
Reason: It prevents anthracycline induced cardiotoxicity
Long Essays:

(2x10=20)

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2. Classify Beta lactam antibiotics. Discuss the mechanism of action, therapeutic uses and adverse
effects of third generation Cephalosporins. Discuss the rationale of combining Clavulanic acid
with amoxicillin
(3+4+3)
3.

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A 28 year old mother with a ten months old baby wants to space out her next child and consults you
for taking oral contraceptive
s.
a) Classify oral contraceptive pills, discuss the mechanism of action and adverse effects of combined
pills

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b) Discuss the mechanism of action and uses of Mifepristone.
c) Mention two selective estrogen receptor modulators with two uses.
d) Discuss why oral contraceptive pills are contra indicated in a patient on treatment for tuberculosis
(4+2+2+2)
Short Essays:

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(6x6=36
)
4. Discuss the uses and adverse effects of Glucocorticoids.
(3+3)
5. Discuss the mechanism of action, uses and adverse effects of Chloroquine. Discuss the management

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of chloroquine resistant plasmodium falciparum malaria. (4+2)
6. Discuss the mechanism of action, uses and adverse effects of Isoniazid. Discuss the pharmacological
management of MDR Tuberculosis
(4+2
)

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7. Discuss the mechanism of action, uses and adverse effects of Metoclopramide. Discuss the drugs
used for Inflammatory bowel disease.
(3+3
)
8. Discuss the mechanism of action, uses and adverse effects of Methotrexate. Discuss the general

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toxicities of anticancer drugs. (3+3)
9. Discuss the mechanism of action, uses and adverse effects of Fluconazole. Discuss the drugs used
for topical fungal infection. (3+3)
Short Answers:
(6x4=24)

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10. Enumerate "SHARED"
decision making with patients and family members.
11. Mention Four Bisphosphonates with their uses.
12. Discuss the drugs used in Iron poisoning.
13. Discuss the mechanism of action, uses and adverse effects of metronidazole

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.
14. Discuss the mechanism of action, uses and adverse effects of Atorvastatin
.
15. Enumerate the common characteristic features of Aminoglycosides.
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