Download KUHS MBBS 2nd Year 212001 Pharmacology Paper II Dec 2025 Question Paper

2019 Scheme
Q.P. Code: 212001
Reg. no.: .....................
Second Professional MBBS Degree Supplementary Examinations
December 2025

--- Content provided by​ FirstRanker.com ---

Pharmacology - Paper II
(GIT, Hormones, Antibiotics, Chemotherapy and Miscellaneous)
Time: 3 Hours
Total Marks: 100
Answer all questions to the point neatly and legibly ? Do not leave any blank pages between answers

--- Content provided by​ FirstRanker.com ---

Indicate the question number correctly for the answer in the margin space
Answer all parts of a single question together ? Leave sufficient space between answers
Draw table/diagrams/flow charts wherever necessary
1. Multiple Choice Questions
(20x1=20)

--- Content provided by‍ FirstRanker.com ---

The MCQ questions (Q.No. i to Q.No. xx) shall be answered only in the OMR sheet provided at page
No. 51 of the answer book (the inner portion of the back cover page (PART III)). Responses for MCQs
marked in any other part/page of the answer book will not be valued. For marking the correct responses
use X mark only
Question Numbers i ? v are Single Response Type

--- Content provided by​ FirstRanker.com ---

i. Prokinetic agent producing Q-Tc prolongation and predispose to polymorphic ventricular tachycardia
a) Mosapride
b) Cisapride
c) Itopride
d) Levosulpride

--- Content provided by⁠ FirstRanker.com ---

ii. Which of the following is an Osmotic purgative
a) Lactulose
b) Lubiprostone c) Methyl cellulose d) Bisacodyl
iii. A long and dose dependent Post antibiotic effect is seen with
a) Ampicillin

--- Content provided by​ FirstRanker.com ---

b) Clavulanic acid c) Streptomycin d) Chloramphenicol
iv. Fourth generation Cephalosporin
a) Cefoxitin
b) Cefdinir
c) Cefpirome d) Cefadroxil

--- Content provided by⁠ FirstRanker.com ---

v. Primary important indication for use of calcium disodium edetate
a) Lead poisoning
b) Mercury poisoning
c) Antimony poisoning d) Nickel poisoning
Question Numbers vi ? x are Multiple Response Type. Read the statements and mark the answers

--- Content provided by FirstRanker.com ---

appropriately.
vi. Epidermal growth factor receptor inhibitors
1) Gefitinib
2) Erlotinib
3) Imatinib

--- Content provided by​ FirstRanker.com ---

4) Sunitinib
a) 1 & 2 are correct
b) 2 & 3 are correct c) 3 & 4 are correct d) 1 & 4 are correct
vii. Anthelmintics used for the treatment of Neurocysticercosis
1) Albendazole

--- Content provided by​ FirstRanker.com ---

2) Praziquantel
3) Ivermectin
4) Diethylcarbamazine
a) 1 & 2 are correct
b) 2 & 3 are correct c) 3 & 4 are correct d) 1 & 4 are correct

--- Content provided by​ FirstRanker.com ---

viii. Metronidazole is useful in the treatment of
1) Intestinal amoebiasis 3) Leishmaniasis
2) Anaerobic bacterial infection
4) Filariasis
a) 1 & 2 are correct

--- Content provided by FirstRanker.com ---

b) 2 & 3 are correct c) 3 & 4 are correct d) 1 & 4 are correct
ix. Antimalarial drugs used for causal prophylaxis
1) Mefloquine
2) Primaquine
3) Proguanil

--- Content provided by​ FirstRanker.com ---

4) Chloroquine
a) 1 & 2 are correct
b) 2 & 3 are correct c) 3 & 4 are correct d) 1 & 4 are correct
x. Topical antifungal agents
1) Tolnaftate

--- Content provided by‌ FirstRanker.com ---

2) Voriconazole 3) Caspofungin 4) Griseofulvin
a) 1 & 2 are correct
b) 2 & 3 are correct c) 3 & 4 are correct d) 1 & 4 are correct
Question Numbers xi ? xv are based on case scenarios. Read the statements and mark the answers
accordingly.

--- Content provided by​ FirstRanker.com ---

A 52 year old man is brought to the hospital emergency department in a confused and delirious state. He
had an elevated temperature for more than 24 hr, severe headache and nausea and vomiting. Lumbar
puncture reveals an elevated opening pressure and cerebrospinal fluid analysis shows an elevated
protein, decreased glucose and an increased neutrophils. Gram staining reveals the presence of Gram
positive diplococci and a diagnosis of purulent meningitis is made

--- Content provided by‌ FirstRanker.com ---

xi. Treatment of this patient should be initiated immediately with intravenous administration of
a) Amoxicillin
b) Cephalexin
c) Ceftriaxone + Vancomycin d) Nafcillin
xii. Resistance to Pneumococci to penicillin G is due to

--- Content provided by⁠ FirstRanker.com ---

a) Alterations in porin structure
b) Beta ? lactamase production
c) Changes in chemical structure of target penicillin binding proteins
d) Changes in the d-Ala-d-Ala building block of peptidoglycan precursor
(PTO)

--- Content provided by‌ FirstRanker.com ---

---

xiii. If the patient had the gram stain of the smear of cerebrospinal fluid revealing gram-positive rods
resembling diphtheroids, the antibiotic regimen for empiric treatment would include
a) Ampicillin

--- Content provided by FirstRanker.com ---

b) Cefoxitin
c) Ceftriaxone
d) Fosfomycin
xiv. The primary mechanism of antibacterial action of Penicillin involves inhibition of
a) Beta-lactamases

--- Content provided by‌ FirstRanker.com ---

c) N-acetylmuramic acid synthesis
b) Cell membrane synthesis
d) Cell wall synthesis
xv. Which statement about Vancomycin is accurate
a) Active drug against methicillin-resistant staphylococci

--- Content provided by​ FirstRanker.com ---

b) Bacteriostatic
c) Binds to penicillin binding proteins
d) Inhibits transpeptidation
Question numbers xvi ? xx consists of statements ? Assertion (A) and Reason (R). Answer these
questions by selecting the appropriate options given below.

--- Content provided by‍ FirstRanker.com ---

a) Both A & R are true and R is the correct explanation c) A is true but R is false
b) Both A & R are true and R is not the correct explanation d) A is false but R is true
xvi. Assertion: Lafutidine is indicated in the treatment of dyspepsia, peptic ulcer and GERD
Reason: Lafutidine decrease acid secretion, enhance mucosal blood flow and has gastro protective
effect by increasing mucus production

--- Content provided by​ FirstRanker.com ---

xvii. Assertion: Superactive GnRH agonists are more potent than natural GnRH and long acting
Reason: Superactive GnRH agonists have higher affinity for GnRH receptors and are resistant to
enzymatic hydrolysis
xviii. Assertion: Cimetidine produce gynaecomastia, loss of libido and produce impotence when given in
lower doses for longer duration of time

--- Content provided by⁠ FirstRanker.com ---

Reason: Cimetidine increase plasma prolactin and inhibits degradation of estradiol by liver
xix. Assertion: Concurrent administration of Erythromycin and drugs like Terfenadine and Astemizole
increase the risk of Q-Tc prolongation and severe ventricular tachycardia
Reason: Since erythromycin is an enzyme inducer, it induces CYP 3A4 and increase the metabolism of
Terfenadine and Astemizole

--- Content provided by FirstRanker.com ---

xx. Assertion: Monotherapy with INH in tuberculosis management, resistant infection is reduced
Reason: High degree of resistance to INH is shown by the inherently resistant tubercle organisms by
mutation of the catalase-peroxidase (KatG) gene
Long Essays:

--- Content provided by‌ FirstRanker.com ---

(2x10=20)
2. Classify the oral antidiabetic drugs. Discuss the mechanism of action, interactions and adverse effects
produced by Sulfonylureas. How will you manage a patient with Diabetic ketoacidosis
(4+3+3)
3. A 68 year old woman presented complaints of generalized joint pain since 2 months that was progressive

--- Content provided by​ FirstRanker.com ---

gradually. She also had morning stiffness. Physical examination reveals bilateral symmetrical swelling.
Blood haematology shows raised erythrocyte sedimentation rate and rheumatoid factor
a) Classify the drugs used for treatment of Rheumatoid arthritis
b) Explain in detail the mechanism of action, therapeutic uses and adverse effects of Methotrexate
c) Add a note on DMRDs

--- Content provided by FirstRanker.com ---

(3+4+3)
Short Essays:
(6x6=36)
4. Enumerate therapeutic uses of Corticosteroids
5. Treatment of pulmonary tuberculosis

--- Content provided by‌ FirstRanker.com ---

6. Discuss the pharmacology of Selective Estrogen Receptor Modulators
7. Write about the mechanism of action and therapeutic uses of Fluoroquinolones
8. Discuss the role of Artemisinin derivatives in malaria treatment
9. Discuss in detail penicillins
Short Answers:

--- Content provided by FirstRanker.com ---

(6x4=24)
10. Write about the drugs used for treatment of Thyroid storm
11. Management of Helicobacter pylori infection
12. Discuss the advice to be given to a newly detected diabetic lady (82 Kg)

--- Content provided by​ FirstRanker.com ---

13. How will you treat a case of lower urinary tract infection in a female of 32 years, caused by E.Coli
14. What are the common toxicities produced by cancer chemotherapy
15. Metoclopramide
******************

---

CORRECTION / NO-CORRECTION FILE

--- Content provided by FirstRanker.com ---

QPCODE: 212001 Dated: 17-12-2025
Question No. 1 (x)
Options (2) replaced with "Posaconazole" and (4) replaced with " Ciclopirox".
Question No.3 (c)
Replaced with "Add a note of DMARDs."

--- Content provided by‌ FirstRanker.com ---

Question No.5
Modified as "Treatment of drug sensitive pulmonary tuberculosis."
Corrections/Modifications/Replacement of Questions if any shall be made available to all
students. Take the print out of the Correction File in such cases and distribute to all
students.

--- Content provided by​ FirstRanker.com ---

(Sd/-)
CONTROLLER OF EXAMINATIONS

---