2019 Scheme
Q.P. Code: 212001
Reg. no.: .....................
Second Professional MBBS Degree Supplementary (SAY) Examinations
March 2025
(GIT, Hormones, Antibiotics, Chemotherapy and Miscellaneous)
Time: 3 Hours
Total Marks: 100
Answer all questions to the point neatly and legibly ? Do not leave any blank pages between answers
Answer all parts of a single question together ? Leave sufficient space between answers
Draw table/diagrams/flow charts wherever necessary
1. Multiple Choice Questions
(1x20=20)
questions at page No. 51 of the answer book (the inner portion of the back cover page (PART III)).
Responses for MCQs marked in any other part/page of the answer book will not be valued
Question Numbers i ? v are Single Response Type
i. Which anti-diarrhoeal drug acts by inhibiting intestinal motility via opioid receptors
b) Bismuth subsalicylate
c) Dicyclomine
d) Mesalamine
ii. The anticancer drug which acts by inhibiting Topoisomerase II, thereby causing DNA strand breaks is:
b) Doxorubicin
c) Vinblastine
d) 5-Fluorouracil
iii. The potent inhibitor of bacterial cell wall synthesis used for Neisseria gonorrhoeae infections is:
c) Erythromycin
b) Clindamycin
d) Trimethoprim-sulfamethoxazole
iv. Which of the following is the most common adverse effect of long-term use of oral contraceptives
b) Thromboembolism
c) Hypothyroidism
d) Hyperkalemia
v. The mechanism of action of the drug terbinafine is:
b) Disruption of fungal cell membrane integrity
c) Inhibition of squalene epoxidase in the ergosterol synthesis pathway
d) Inhibition of fungal DNA synthesis
Question Numbers vi ? x are Multiple Response Type. Read the statements and mark the answers
vi. The anticancer agents causing renal toxicity as adverse effect are:
1) Cisplatin
2) Methotrexate
3) Cyclophosphamide
a) 2 & 4 are correct
b) 1 & 2 are correct
c) 1 & 3 are correct
d) 1 & 4 are correct
1) Sulfasalazine
2) Dicyclomine
3) Metronidazole
4) Ondansetron
b) 1 & 2 are correct
c) 1 & 3 are correct
d) 2 & 4 are correct
viii. The drug safe in pregnancy
2) Ciprofloxacin
3) Cefixime
4) Tetracycline
a) 1 & 2 are correct
c) 1 & 4 are correct
d) 2 & 4 are correct
ix. The antibiotics known to target bacterial protein synthesis are:
1) Erythromycin
3) Tetracycline
4) Vancomycin
a) 1 & 4 are correct
b) 1 & 2 are correct
d) 2 & 4 are correct
x. Which drugs are used as part of post-exposure prophylaxis (PEP) in HIV exposure
1) Emtricitabine
2) Tenofovir
4) Zidovudine
a) 1 & 4 are correct
b) 1 & 2 are correct
c) 1 & 3 are correct
Question Numbers xi ? xv are based on case scenarios. Read the statements and mark the answers
accordingly.
Patient: Mr. John Taylor, a 45-year-old man presents with the chief complaint: Severe heartburn and
regurgitation of food after meals, especially at night. Medical History: Overweight (BMI: 29), Occasional
for the past 3 months. Symptoms are worse when lying down, particularly at night. Difficulty swallowing at
times. Has been self-medicating with over-the-counter antacids but reports no significant relief. Physical
Examination: Normal vital signs, No signs of systemic illness, abdominal tenderness or masses and not
anaemic. Diagnosis: Gastroesophageal reflux disease (GERD)
for GERD
a) Proton pump inhibitors (PPIs)
c) Antacids
b) H2-receptor antagonists
(PTO)
xii. Mr. Taylor's symptoms are poorly controlled with over-the-counter antacids. Which of the following is the
most appropriate next step in his treatment
a) Increase the dose of antacids
b) Start a Proton Pump Inhibitor (PPI)
d) Recommend a high-fiber diet
xiii. The known side effect of long-term use of proton pump inhibitors (PPIs) is
a) Hyperglycemia
c) Vitamin B12 deficiency
d) Relapse of GERD
xiv. The primary mechanism of action of H2-receptor antagonists in the treatment of GERD is
a) Increase gastric acid secretion
b) Decrease gastric acid secretion
d) Neutralize gastric acid
xv. The drug preferred as an adjunctive therapy in GERD by accelerating gastric emptying is
a) Metoclopramide
c) Ranitidine
d) Sucralfate
Question numbers xvi ? xx consists of statements ? Assertion (A) and Reason (R). Answer these
questions by selecting the appropriate options given below.
Reason (R): Drugs with low plasma protein binding can cause hemolysis.
a) Both A and R are true and R is the correct explanation of A
c) A is true but R is false
b) Both A and R are true and R is not the correct explanation of A
xvii. Assertion (A): Bedaquiline is used along with clofazimine in XDR TB.
Reason (R): Two drugs acting on same target can antagonize each other.
a) Both A and R are true and R is the correct explanation of A
c) A is true but R is false
d) A is false but R is true
xviii. Assertion (A): Azathioprine dose is decreased with Allopurinol.
Reason (R): Azathioprine and allopurinol cause bone marrow suppression.
a) Both A and R are true and R is the correct explanation of A
b) Both A and R are true and R is not the correct explanation of A
d) A is false but R is true
xix. Assertion (A): Propranolol is often used to manage symptoms of hyperthyroidism.
Reason (R): Propranolol is a non-selective beta-blocker that reduces the symptoms of hyperthyroidism
a) Both A and R are true and R is the correct explanation of A
c) A is true but R is false
b) Both A and R are true and R is not the correct explanation of A
d) A is false but R is true
Staphylococcus aureus (MRSA).
Reason (R): Vancomycin inhibits the formation of bacterial cell walls by binding to D-alanyl-
D-alanine, a component of the peptidoglycan precursor.
a) Both A and R are true and R is the correct explanation of A
b) Both A and R are true and R is not the correct explanation of A
d) A is false but R is true
Long Essays:
2. Classify antifungal drugs. Explain the mechanism of action, uses, and adverse effects of Amphotericin B.
Add a note on the various liposomal formulations of Amphotericin B
(2+6+2)
3. A 30 year old female with systemic lupus erythamatosis was given prednisolone 40 mg/day
b) Enumerate four clinical uses of corticosteroids, with its rationale for use
c) Enumerate four serious adverse effects of prolonged steroid use
(4+4+2)
Short Essays:
4. Classify uterine stimulants and relaxants with suitable examples. Explain the rationale for the
use of oxytocin in prevention of postpartum haemorrhage (PPH).
(4+2)
5. Write in detail on the mechanism of action, uses, and adverse effects of aminoglycoside antibiotics.
effective group.
(3+3)
7. Describe the mechanism of action, adverse effects and uses of Rifampicin.
8. Mechanism of action, therapeutic uses and adverse effects of vinca alkaloids.
right wrist joint. After investigation, the physician made a diagnosis of Osteoporosis. She was prescribed
Alendronate. Explain the mechanism of action and adverse effects of Alendronate. (4+2)
Short Answers:
10. Enumerate SERMs. Write in detail about any one member.
(2+4)
11. What is the pharmacological basis for the use of pyridoxine along with isoniazid.
12. Mechanism of action, uses and adverse effects of Radio active iodine.
14. Enumerate insulin analogues and tabulate their pharmacokinetic characteristics.
15. Discuss the role of empathy in patient care.
*******************
Q.P. Code: 212001
Reg. no.: .....................
Second Professional MBBS Degree Supplementary (SAY) Examinations
March 2025
--- Content provided by FirstRanker.com ---
Pharmacology - Paper II(GIT, Hormones, Antibiotics, Chemotherapy and Miscellaneous)
Time: 3 Hours
Total Marks: 100
Answer all questions to the point neatly and legibly ? Do not leave any blank pages between answers
--- Content provided by FirstRanker.com ---
Indicate the question number correctly for the answer in the margin spaceAnswer all parts of a single question together ? Leave sufficient space between answers
Draw table/diagrams/flow charts wherever necessary
1. Multiple Choice Questions
(1x20=20)
--- Content provided by FirstRanker.com ---
The MCQ questions (Q.No. i to Q.No. xx) shall be written in the space provided for answering MCQquestions at page No. 51 of the answer book (the inner portion of the back cover page (PART III)).
Responses for MCQs marked in any other part/page of the answer book will not be valued
Question Numbers i ? v are Single Response Type
i. Which anti-diarrhoeal drug acts by inhibiting intestinal motility via opioid receptors
--- Content provided by FirstRanker.com ---
a) Loperamideb) Bismuth subsalicylate
c) Dicyclomine
d) Mesalamine
ii. The anticancer drug which acts by inhibiting Topoisomerase II, thereby causing DNA strand breaks is:
--- Content provided by FirstRanker.com ---
a) Methotrexateb) Doxorubicin
c) Vinblastine
d) 5-Fluorouracil
iii. The potent inhibitor of bacterial cell wall synthesis used for Neisseria gonorrhoeae infections is:
--- Content provided by FirstRanker.com ---
a) Ceftriaxonec) Erythromycin
b) Clindamycin
d) Trimethoprim-sulfamethoxazole
iv. Which of the following is the most common adverse effect of long-term use of oral contraceptives
--- Content provided by FirstRanker.com ---
a) Cataractb) Thromboembolism
c) Hypothyroidism
d) Hyperkalemia
v. The mechanism of action of the drug terbinafine is:
--- Content provided by FirstRanker.com ---
a) Inhibition of fungal cell wall synthesisb) Disruption of fungal cell membrane integrity
c) Inhibition of squalene epoxidase in the ergosterol synthesis pathway
d) Inhibition of fungal DNA synthesis
Question Numbers vi ? x are Multiple Response Type. Read the statements and mark the answers
--- Content provided by FirstRanker.com ---
appropriately.vi. The anticancer agents causing renal toxicity as adverse effect are:
1) Cisplatin
2) Methotrexate
3) Cyclophosphamide
--- Content provided by FirstRanker.com ---
4) Trastuzumaba) 2 & 4 are correct
b) 1 & 2 are correct
c) 1 & 3 are correct
d) 1 & 4 are correct
--- Content provided by FirstRanker.com ---
vii. The drugs widely preferred to treat irritable bowel syndrome (IBS)1) Sulfasalazine
2) Dicyclomine
3) Metronidazole
4) Ondansetron
--- Content provided by FirstRanker.com ---
a) 1 & 4 are correctb) 1 & 2 are correct
c) 1 & 3 are correct
d) 2 & 4 are correct
viii. The drug safe in pregnancy
--- Content provided by FirstRanker.com ---
1) Amoxicillin2) Ciprofloxacin
3) Cefixime
4) Tetracycline
a) 1 & 2 are correct
--- Content provided by FirstRanker.com ---
b) 1 & 3 are correctc) 1 & 4 are correct
d) 2 & 4 are correct
ix. The antibiotics known to target bacterial protein synthesis are:
1) Erythromycin
--- Content provided by FirstRanker.com ---
2) Ciprofloxacin3) Tetracycline
4) Vancomycin
a) 1 & 4 are correct
b) 1 & 2 are correct
--- Content provided by FirstRanker.com ---
c) 1 & 3 are correctd) 2 & 4 are correct
x. Which drugs are used as part of post-exposure prophylaxis (PEP) in HIV exposure
1) Emtricitabine
2) Tenofovir
--- Content provided by FirstRanker.com ---
3) Enfuvirtide4) Zidovudine
a) 1 & 4 are correct
b) 1 & 2 are correct
c) 1 & 3 are correct
--- Content provided by FirstRanker.com ---
d) 2 & 4 are correctQuestion Numbers xi ? xv are based on case scenarios. Read the statements and mark the answers
accordingly.
Patient: Mr. John Taylor, a 45-year-old man presents with the chief complaint: Severe heartburn and
regurgitation of food after meals, especially at night. Medical History: Overweight (BMI: 29), Occasional
--- Content provided by FirstRanker.com ---
alcohol use. No known drug allergies. Presenting Symptoms: Heartburn and acid regurgitation after mealsfor the past 3 months. Symptoms are worse when lying down, particularly at night. Difficulty swallowing at
times. Has been self-medicating with over-the-counter antacids but reports no significant relief. Physical
Examination: Normal vital signs, No signs of systemic illness, abdominal tenderness or masses and not
anaemic. Diagnosis: Gastroesophageal reflux disease (GERD)
--- Content provided by FirstRanker.com ---
xi. Which of the following classes of drugs is most commonly used as the first-line pharmacologic treatmentfor GERD
a) Proton pump inhibitors (PPIs)
c) Antacids
b) H2-receptor antagonists
--- Content provided by FirstRanker.com ---
d) Prokinetic agents(PTO)
xii. Mr. Taylor's symptoms are poorly controlled with over-the-counter antacids. Which of the following is the
most appropriate next step in his treatment
a) Increase the dose of antacids
--- Content provided by FirstRanker.com ---
c) Prescribe a prokinetic agentb) Start a Proton Pump Inhibitor (PPI)
d) Recommend a high-fiber diet
xiii. The known side effect of long-term use of proton pump inhibitors (PPIs) is
a) Hyperglycemia
--- Content provided by FirstRanker.com ---
b) Hypercalcemiac) Vitamin B12 deficiency
d) Relapse of GERD
xiv. The primary mechanism of action of H2-receptor antagonists in the treatment of GERD is
a) Increase gastric acid secretion
--- Content provided by FirstRanker.com ---
c) Improve gastric motilityb) Decrease gastric acid secretion
d) Neutralize gastric acid
xv. The drug preferred as an adjunctive therapy in GERD by accelerating gastric emptying is
a) Metoclopramide
--- Content provided by FirstRanker.com ---
b) Lansoprazolec) Ranitidine
d) Sucralfate
Question numbers xvi ? xx consists of statements ? Assertion (A) and Reason (R). Answer these
questions by selecting the appropriate options given below.
--- Content provided by FirstRanker.com ---
xvi. Assertion (A): Sulphonamide's can cause kernicterus in newborns.Reason (R): Drugs with low plasma protein binding can cause hemolysis.
a) Both A and R are true and R is the correct explanation of A
c) A is true but R is false
b) Both A and R are true and R is not the correct explanation of A
--- Content provided by FirstRanker.com ---
d) A is false but R is truexvii. Assertion (A): Bedaquiline is used along with clofazimine in XDR TB.
Reason (R): Two drugs acting on same target can antagonize each other.
a) Both A and R are true and R is the correct explanation of A
c) A is true but R is false
--- Content provided by FirstRanker.com ---
b) Both A and R are true and R is not the correct explanation of Ad) A is false but R is true
xviii. Assertion (A): Azathioprine dose is decreased with Allopurinol.
Reason (R): Azathioprine and allopurinol cause bone marrow suppression.
a) Both A and R are true and R is the correct explanation of A
--- Content provided by FirstRanker.com ---
c) A is true but R is falseb) Both A and R are true and R is not the correct explanation of A
d) A is false but R is true
xix. Assertion (A): Propranolol is often used to manage symptoms of hyperthyroidism.
Reason (R): Propranolol is a non-selective beta-blocker that reduces the symptoms of hyperthyroidism
--- Content provided by FirstRanker.com ---
by blocking the effects of excessive thyroid hormones on the heart.a) Both A and R are true and R is the correct explanation of A
c) A is true but R is false
b) Both A and R are true and R is not the correct explanation of A
d) A is false but R is true
--- Content provided by FirstRanker.com ---
xx. Assertion (A): Vancomycin is used primarily to treat infections caused by Methicillin-resistantStaphylococcus aureus (MRSA).
Reason (R): Vancomycin inhibits the formation of bacterial cell walls by binding to D-alanyl-
D-alanine, a component of the peptidoglycan precursor.
a) Both A and R are true and R is the correct explanation of A
--- Content provided by FirstRanker.com ---
c) A is true but R is falseb) Both A and R are true and R is not the correct explanation of A
d) A is false but R is true
Long Essays:
--- Content provided by FirstRanker.com ---
(2x10=20)2. Classify antifungal drugs. Explain the mechanism of action, uses, and adverse effects of Amphotericin B.
Add a note on the various liposomal formulations of Amphotericin B
(2+6+2)
3. A 30 year old female with systemic lupus erythamatosis was given prednisolone 40 mg/day
--- Content provided by FirstRanker.com ---
a) What are the precautions to be taken in this patient. Why.b) Enumerate four clinical uses of corticosteroids, with its rationale for use
c) Enumerate four serious adverse effects of prolonged steroid use
(4+4+2)
Short Essays:
--- Content provided by FirstRanker.com ---
(6x6=36)4. Classify uterine stimulants and relaxants with suitable examples. Explain the rationale for the
use of oxytocin in prevention of postpartum haemorrhage (PPH).
(4+2)
5. Write in detail on the mechanism of action, uses, and adverse effects of aminoglycoside antibiotics.
--- Content provided by FirstRanker.com ---
6. Enumerate Antiemetics. Add a brief note on mechanism of action, uses and adverse effects of the mosteffective group.
(3+3)
7. Describe the mechanism of action, adverse effects and uses of Rifampicin.
8. Mechanism of action, therapeutic uses and adverse effects of vinca alkaloids.
--- Content provided by FirstRanker.com ---
9. A 60-year-old lady presents with back pain and in the legs. She also complains of a recent fracture in theright wrist joint. After investigation, the physician made a diagnosis of Osteoporosis. She was prescribed
Alendronate. Explain the mechanism of action and adverse effects of Alendronate. (4+2)
Short Answers:
--- Content provided by FirstRanker.com ---
(6x4=24)10. Enumerate SERMs. Write in detail about any one member.
(2+4)
11. What is the pharmacological basis for the use of pyridoxine along with isoniazid.
12. Mechanism of action, uses and adverse effects of Radio active iodine.
--- Content provided by FirstRanker.com ---
13. Contra indications and drug interactions of oral contraceptive pills.14. Enumerate insulin analogues and tabulate their pharmacokinetic characteristics.
15. Discuss the role of empathy in patient care.
*******************
--- Content provided by FirstRanker.com ---