2019 and 2024 Scheme
Q.P. Code: 115001
Reg. no.: .....................
First Professional MBBS Degree Supplementary (SAY) Examinations November 2025
Biochemistry Paper - I
Total Marks: 100
Answer all questions to the point neatly and legibly ? Do not leave any blank pages between answers
Indicate the question number correctly for the answer in the margin space
Answer all parts of a single question together ? Leave sufficient space between answers
1. Multiple Choice Questions
(20x1=20)
The MCQ questions (Q.No. i to Q.No. xx) shall be answered only in the OMR sheet provided at page
No. 51 of the answer book (the inner portion of the back cover page (PART III)). Responses for MCQs
responses use X mark only
Questions i-v are single response type questions
i. Which of the following subcellular organelle is involved in destroying invading viruses and bacteria
a) Peroxisomes
c) Ribosomes d) Microsomes
ii. Deficiency of one of the following trace elements causes loss of taste sensation
a) Copper
b) Selenium
d) Zinc
iii. Which of the following enzymes does not require Pyridoxal phosphate as co-enzyme
a) Alanine Amino Transferase
c) ALA Synthase
d) Pyruvate Dehydrogenase
iv. Which of the electron carriers is soluble and mobile
a) Co Q
b) Cytochrome c1 c) Cytochrome a d) Cytochrome b
a) Caused by ATP7B gene mutation
c) Zinc can be given as treatment
b) Serum ceruloplasmin levels are increased d) Kayser Fleischer rings can be seen
Question numbers vi-x are multiple response type questions. Read the statements and mark the
vi. Choose the metabolic pathways that take place only partly in the mitochondria
1) Urea synthesis 2) Heme synthesis 3) Gluconeogenesis
4) Cholesterol synthesis
a) 1, 2 & 3 are correct
b) 1, 2 & 4 are correct
d) 2, 3 & 4 are correct
vii. The false statements about Lipoprotein metabolism
1) Chylomicrons have the smallest diameter
2) LDL carries cholesterol
4) VLDL carries exogenous dietary triacyl glycerol
a) 1 & 3 are correct b) 2 & 4 are correct
c) 1 & 4 are correct d) 2 & 3 are correct
1) Heme 2) Creatine
3) Glutathione
4) Thyroxine
a) 1, 2 & 3 are correct
b) 1, 2 & 4 are correct
d) 2, 3 & 4 are correct
ix. True about HMP Shunt pathway
1) Produces ATP
2) Produces uronic acid
4) Regulatory enzyme is Glucose 6 Phosphate dehydrogenase
a) 1 & 3 are correct b) 1 & 4 are correct
c) 3 & 4 are correct d) 2 & 3 are correct
1) Pyruvate dehydrogenase 2) Carbonic anhydrase
3) Enolase 4) Cytochrome oxidase
a) 1, 2 & 3 are correct
c) 1, 3 & 4 are correct
d) 2, 3 & 4 are correct
For Questions xi-xv there are two statements marked as-Assertion (A) and Reason (R). Mark your
answer as per the options provided
a) Both A and R are correct but R is not the reason for A
b) Both A and R are correct and R is the reason for A
d) A Correct R incorrect
xi. Assertion: Ascorbic Acid deficiency leads to bleeding gums
xii. Assertion: Muscle will not release glucose to the blood stream
Reason: Muscle tissue does not contain glucose -6- phosphatase
xiii. Assertion: Vitamin B12 deficiency causes simultaneous folate deficiency
Reason: Free THFA cannot be regenerated in the deficiency of Vitamin B12
xiv. Assertion: Phenyl alanine is a non-essential amino acid
Reason: Phenyl alanine can be synthesized from tyrosine
xv. Assertion: Liver is the only organ that can excrete cholesterol through bile
Reason: Liver Synthesizes cholesterol
Question numbers xvi-xx are case scenario-based questions
A 53-year-old obese man, known to be a prediabetic got severe crushing retrosternal chest pain, radiating to
his left shoulder. ECG showed ST elevation, T wave inversion and Q waves. He was diagnosed as having
abdominal scan showed presence of fatty liver disease. Serum was sent for laboratory investigations
xvi. All of the following are likely to be elevated in the serum of a patient with Myocardial Infarction, EXCEPT
a) Creatine Kinase-MB
b) Troponin I c) Amylase
xvii. Which of the following is most likely to be the result of HbA1c of a pre-diabetic
a) HbA1c of 5.7 - 6.5
b) HbA1c of 5 - 7 c) HbA1c of 5.2 - 6 d) HbA1c of 6.5 - 7.5
xviii. He was advised to increase his intake of dietary fiber. Which of the following is a dietary fiber
b) Pyridoxine c) Peptone
d) Palmitate
xix. Which of the following factors will function as a lipotropic factor for the fatty liver
a) Stearic acid
d) Linolenic acid
xx. Renal threshold for glucose is
a) 140mg/dL
b) 170mg/dL c) 180mg/dL d) 160mg/dL
(2x10=20)
2. A ten year old girl presented to the out-patient department of the hospital from a nearby village with
excessive tiredness, weakness, abdominal pain with frequent alternate episodes of constipation and
diarrhoea. She gave a history of frequently playing with mud, walking barefoot with poor personal hygiene
koilonychia to be present. Laboratory examination revealed low haemoglobin level & hypochromic
microcytic RBC. Microscopic examination of fresh stool samples showed presence of hook worm eggs.
a) Name the nutrient whose deficiency can cause the above manifestations
b) Mention any Two dietary sources of the nutrient.
d) Describe the dietary absorption and transport of the nutrient.
(1+1+4+4)
3. Enumerate the reactions of urea cycle and explain its regulation. Add a note on disorders of the urea cycle.
(5+2+3)
(6x6=36)
4. A ten year old boy presented with a history of fever since 3 days, disturbance of consciousness,
accompanied by thirst, fruity odour of breath and deep laboured breathing. On examination pulse=
120/min, blood pressure= 90/50 mmHg, temperature= 38, respiratory rate =30 breaths/min, Blood
a) What is the probable diagnosis
b) Explain how ketone bodies are formed and utilised in the body
(1+5)
5. What is gluconeogenesis. Name the substrates of this pathway. Describe the reactions catalysed by the
(1+1+4)
6. Define Basal Metabolic Rate (BMR), mention how it can be measured, what are the normal values.
Describe the factors determining BMR.
(1+1+1+3)
enzyme inhibition with the help of atleast Four examples.
(1+1+4)
8. Describe the metabolic changes in fed state.
9. A five year old girl, from a rural area was brought to a Primary Health Care Centre with a history of
infections. On examination she was found to have Vitamin A deficiency.
a) List the signs/ manifestations of vitamin A deficiency.
b) Mention the dietary sources of Vitamin A.
c) Explain the biochemical functions of Vitamin A.
Short Answers
(6x4=24)
10. Inhibitors of oxidative phosphorylation.
11. Mitochondria.
13. List any FOUR phospholipids with their significance.
14. Name the enzymes that help in the diagnosis of a) Liver disease b) Pancreatic disease
15. Write a note on why it is important for a physician to be committed to lifelong learning.
******************
Q.P. Code: 115001
Reg. no.: .....................
First Professional MBBS Degree Supplementary (SAY) Examinations November 2025
Biochemistry Paper - I
--- Content provided by FirstRanker.com ---
Time: 3 HoursTotal Marks: 100
Answer all questions to the point neatly and legibly ? Do not leave any blank pages between answers
Indicate the question number correctly for the answer in the margin space
Answer all parts of a single question together ? Leave sufficient space between answers
--- Content provided by FirstRanker.com ---
Draw table/diagrams/flow charts wherever necessary1. Multiple Choice Questions
(20x1=20)
The MCQ questions (Q.No. i to Q.No. xx) shall be answered only in the OMR sheet provided at page
No. 51 of the answer book (the inner portion of the back cover page (PART III)). Responses for MCQs
--- Content provided by FirstRanker.com ---
marked in any other part/page of the answer book will not be valued. For marking the correctresponses use X mark only
Questions i-v are single response type questions
i. Which of the following subcellular organelle is involved in destroying invading viruses and bacteria
a) Peroxisomes
--- Content provided by FirstRanker.com ---
b) Lysosomesc) Ribosomes d) Microsomes
ii. Deficiency of one of the following trace elements causes loss of taste sensation
a) Copper
b) Selenium
--- Content provided by FirstRanker.com ---
c) Irond) Zinc
iii. Which of the following enzymes does not require Pyridoxal phosphate as co-enzyme
a) Alanine Amino Transferase
c) ALA Synthase
--- Content provided by FirstRanker.com ---
b) Glycogen Phosphorylased) Pyruvate Dehydrogenase
iv. Which of the electron carriers is soluble and mobile
a) Co Q
b) Cytochrome c1 c) Cytochrome a d) Cytochrome b
--- Content provided by FirstRanker.com ---
v. All the following are TRUE about Wilson's disease EXCEPTa) Caused by ATP7B gene mutation
c) Zinc can be given as treatment
b) Serum ceruloplasmin levels are increased d) Kayser Fleischer rings can be seen
Question numbers vi-x are multiple response type questions. Read the statements and mark the
--- Content provided by FirstRanker.com ---
answers appropriately.vi. Choose the metabolic pathways that take place only partly in the mitochondria
1) Urea synthesis 2) Heme synthesis 3) Gluconeogenesis
4) Cholesterol synthesis
a) 1, 2 & 3 are correct
--- Content provided by FirstRanker.com ---
c) 1, 3 & 4 are correctb) 1, 2 & 4 are correct
d) 2, 3 & 4 are correct
vii. The false statements about Lipoprotein metabolism
1) Chylomicrons have the smallest diameter
--- Content provided by FirstRanker.com ---
3) HDL has maximum amount of proteins2) LDL carries cholesterol
4) VLDL carries exogenous dietary triacyl glycerol
a) 1 & 3 are correct b) 2 & 4 are correct
c) 1 & 4 are correct d) 2 & 3 are correct
--- Content provided by FirstRanker.com ---
viii. Products formed from glycine are1) Heme 2) Creatine
3) Glutathione
4) Thyroxine
a) 1, 2 & 3 are correct
--- Content provided by FirstRanker.com ---
c) 1, 3 & 4 are correctb) 1, 2 & 4 are correct
d) 2, 3 & 4 are correct
ix. True about HMP Shunt pathway
1) Produces ATP
--- Content provided by FirstRanker.com ---
3) NADPH is produced in oxidative phase2) Produces uronic acid
4) Regulatory enzyme is Glucose 6 Phosphate dehydrogenase
a) 1 & 3 are correct b) 1 & 4 are correct
c) 3 & 4 are correct d) 2 & 3 are correct
--- Content provided by FirstRanker.com ---
x. Choose the metalloenzymes1) Pyruvate dehydrogenase 2) Carbonic anhydrase
3) Enolase 4) Cytochrome oxidase
a) 1, 2 & 3 are correct
c) 1, 3 & 4 are correct
--- Content provided by FirstRanker.com ---
b) 1, 2 & 4 are correctd) 2, 3 & 4 are correct
For Questions xi-xv there are two statements marked as-Assertion (A) and Reason (R). Mark your
answer as per the options provided
a) Both A and R are correct but R is not the reason for A
--- Content provided by FirstRanker.com ---
c) Both A and R are incorrectb) Both A and R are correct and R is the reason for A
d) A Correct R incorrect
xi. Assertion: Ascorbic Acid deficiency leads to bleeding gums
--- Content provided by FirstRanker.com ---
Reason: Due to its role in collagen cross linkingxii. Assertion: Muscle will not release glucose to the blood stream
Reason: Muscle tissue does not contain glucose -6- phosphatase
xiii. Assertion: Vitamin B12 deficiency causes simultaneous folate deficiency
Reason: Free THFA cannot be regenerated in the deficiency of Vitamin B12
--- Content provided by FirstRanker.com ---
xiv. Assertion: Phenyl alanine is a non-essential amino acid
Reason: Phenyl alanine can be synthesized from tyrosine
xv. Assertion: Liver is the only organ that can excrete cholesterol through bile
Reason: Liver Synthesizes cholesterol
--- Content provided by FirstRanker.com ---
(PTO)Question numbers xvi-xx are case scenario-based questions
A 53-year-old obese man, known to be a prediabetic got severe crushing retrosternal chest pain, radiating to
his left shoulder. ECG showed ST elevation, T wave inversion and Q waves. He was diagnosed as having
--- Content provided by FirstRanker.com ---
Myocardial Infarction. He did not exercise regularly, ate processed oily foods and was constipated often. Anabdominal scan showed presence of fatty liver disease. Serum was sent for laboratory investigations
xvi. All of the following are likely to be elevated in the serum of a patient with Myocardial Infarction, EXCEPT
a) Creatine Kinase-MB
b) Troponin I c) Amylase
--- Content provided by FirstRanker.com ---
d) Myoglobinxvii. Which of the following is most likely to be the result of HbA1c of a pre-diabetic
a) HbA1c of 5.7 - 6.5
b) HbA1c of 5 - 7 c) HbA1c of 5.2 - 6 d) HbA1c of 6.5 - 7.5
xviii. He was advised to increase his intake of dietary fiber. Which of the following is a dietary fiber
--- Content provided by FirstRanker.com ---
a) Pectinb) Pyridoxine c) Peptone
d) Palmitate
xix. Which of the following factors will function as a lipotropic factor for the fatty liver
a) Stearic acid
--- Content provided by FirstRanker.com ---
b) Palmitic acid c) Butyric acidd) Linolenic acid
xx. Renal threshold for glucose is
a) 140mg/dL
b) 170mg/dL c) 180mg/dL d) 160mg/dL
--- Content provided by FirstRanker.com ---
Long essays--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
(2x10=20)
2. A ten year old girl presented to the out-patient department of the hospital from a nearby village with
excessive tiredness, weakness, abdominal pain with frequent alternate episodes of constipation and
diarrhoea. She gave a history of frequently playing with mud, walking barefoot with poor personal hygiene
--- Content provided by FirstRanker.com ---
and sanitation. On examination, the physician found pallor of the conjunctiva, angular stomatitis andkoilonychia to be present. Laboratory examination revealed low haemoglobin level & hypochromic
microcytic RBC. Microscopic examination of fresh stool samples showed presence of hook worm eggs.
a) Name the nutrient whose deficiency can cause the above manifestations
b) Mention any Two dietary sources of the nutrient.
--- Content provided by FirstRanker.com ---
c) Name any Four proteins that contain this nutrient along with their functions.d) Describe the dietary absorption and transport of the nutrient.
(1+1+4+4)
3. Enumerate the reactions of urea cycle and explain its regulation. Add a note on disorders of the urea cycle.
(5+2+3)
--- Content provided by FirstRanker.com ---
Short Essays:--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
(6x6=36)
4. A ten year old boy presented with a history of fever since 3 days, disturbance of consciousness,
accompanied by thirst, fruity odour of breath and deep laboured breathing. On examination pulse=
120/min, blood pressure= 90/50 mmHg, temperature= 38, respiratory rate =30 breaths/min, Blood
--- Content provided by FirstRanker.com ---
glucose= 407mg/dL and ketone bodies were present in urine.a) What is the probable diagnosis
b) Explain how ketone bodies are formed and utilised in the body
(1+5)
5. What is gluconeogenesis. Name the substrates of this pathway. Describe the reactions catalysed by the
--- Content provided by FirstRanker.com ---
key regulatory enzymes of gluconeogenesis.(1+1+4)
6. Define Basal Metabolic Rate (BMR), mention how it can be measured, what are the normal values.
Describe the factors determining BMR.
(1+1+1+3)
--- Content provided by FirstRanker.com ---
7. What is competitive enzyme inhibition. Mention the salient features and clinical relevance of competitiveenzyme inhibition with the help of atleast Four examples.
(1+1+4)
8. Describe the metabolic changes in fed state.
9. A five year old girl, from a rural area was brought to a Primary Health Care Centre with a history of
--- Content provided by FirstRanker.com ---
frequent falls and bumping into objects after sunset. Her mother gave a history of repeated respiratoryinfections. On examination she was found to have Vitamin A deficiency.
a) List the signs/ manifestations of vitamin A deficiency.
b) Mention the dietary sources of Vitamin A.
c) Explain the biochemical functions of Vitamin A.
--- Content provided by FirstRanker.com ---
(1+1+4)Short Answers
(6x4=24)
10. Inhibitors of oxidative phosphorylation.
11. Mitochondria.
--- Content provided by FirstRanker.com ---
12. What are glycosaminoglycans. Give Four examples and mention their functions.13. List any FOUR phospholipids with their significance.
14. Name the enzymes that help in the diagnosis of a) Liver disease b) Pancreatic disease
15. Write a note on why it is important for a physician to be committed to lifelong learning.
******************
--- Content provided by FirstRanker.com ---