Second Year MBBS
Examination
II MBBS PATHOLOGY PAPER
I
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Max Marks:Time: 3 hours
100
Date: 04-12-2024
Instructions: INSTRUCTIONS: Attempt al
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questions in both sections: (Use separateanswer book for each section)
Section 1
1. Fill in the blanks: 4x1.5=06 (6)
a. Complementary leukocyte molecule for E-
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selectin isb. Most common inherited form of aplastic
anemia is
c. Prostaglandin which has role in
vasoconstriction, bronchoconstriction and
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platelets aggregation isd. Shelf life of packed red cells in SAGM is
2. Answer the followings (Multiple Choice
Questions): 4x1=04 (4)
a. Neurofibromatosis is: a) Autosomal recessive
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b) Autosomal dominant c) X-linked recessive
d) All
b. CD 95 is a marker of: a) Cellular adaptation
b) Intrinsic pathway of apoptosis c)
Reversible cell injury d) Extrinsic pathway of
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apoptosisc. ABO is the most important blood group
system because: a) It has four different blood
group A, B, AB, O b) ABO antigens are
present in most body tissues & fluids c) It
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was first blood group system to bediscovered d) ABO antibodies are invariably
present in plasma in absence of
corresponding antigen
d. The peripheral blood smear in megaloblastic
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anemia shows the following features except:a) Hyper segmented neutrophils b) Increased
reticulocyte count c) Macroovalocytes d)
Cabot ring
3. A 60 year old male present to emergency
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department with complaints of cough, fever andshortness of breath. He was also experiencing
night sweats, fatigue, (15) weight loss for the
last few weeks and haemoptysis since 3 days.
On examination he was febrile, respiratory rate
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24/min, BP 150/84 mmHg. Chest X-ray showstriangular consolidation of Lt upper lobe and
small cavity lesion.3*5= 15
a. Give your diagnosis.
b. Write briefly about relevant lab investigation.
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c. Differential diagnosis for this condition.4. Write short notes on (Any five): 5*2 = 10 (10)
a. Write briefly on Karyotype analysis.
b. Describe role of cytokinins in inflammation.
c. Discuss mechanism of angiogenesis.
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d. Down's syndrome.e. Etiopathogenesis of obesity.
f. Cellular events in acute inflammation.
5. Explain briefly (Any three): 3*5=15 (15)
a. Differences between arterial and venous
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thrombosis.b. Differences between metaplasia and
dysplasia.
c. Discuss grading and staging of tumour.
d. Differences between proto-oncogenes and
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tumour suppressor genes.Section 2
6. A 65 year old male was brought to
emergency room with acute respiratory distress.
On examination he had hypotension and
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tachycardia fever of 103 deg C He was (20)admitted to ICU next day had haematuria and
petechial rash on skin with deranged
coagulation profile and positive D-dimer test.
3*5= 15
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a. What is your diagnosis?b. Explain pathogenesis of this condition.
c. Discuss laboratory findings.
7. Write short notes on (Any three): 3*5=15 (10)
a. Morphological variants of Reed Sternberg
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Cell.b. Haematological findings of CMLC
c. Etiopathogenesis of sickle cell anemia.
d. Describe procedure of component separation
in blood banking.
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8. Explain briefly (Any four): 4*5 = 20 (20)a. Differences between acute and chronic
idiopathic thrombocytopenic purpura.
b. Difference between Intravascular &
Extravascular haemolysis.
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c. Difference between ALL and AMLd. Comparison between platelet disorders and
coagulation disorders
e. Difference between Hodgkin's and Non-
Hodgkin's lymphoma.
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