Download WBUHS MBBS 1st Year WBUHS Biochemistry Paper I 2020 January Question Paper

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The West Bengal University of Health Sciences

MBBS 1^st Professional Examination, January 2020

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Subject: Biochemistry

Paper : 1

Full Marks: 50

Time: 2 ½ hours

Attempt all questions. The figures in the margin indicate full marks.

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Group A

1. a) Name the membrane phospholipids. Draw the structure of lecithin. Write the products formed by the action of different types phospholipases on lecithin. State the physiological role of lysophospholipids & fatty acids produced by the breakdown of lecithin.
   or
   3+1+4+4
2. b) I) State at least one pathological condition which increases the activity of following enzyme in blood:
   

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   4
   1. i) Lipase. ii) CPK-MB. iii) RBC glutathione reductase. iv) SGOT
   II) Explain with the help of enzyme velocity curve how following factors regulate the enzyme Activity:
   8
   1. i) Concentration of enzyme. ii) Concentration of substrate. iii) PH. iv) Temperature.

Group B

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2. Answer any two of the following:
   1. Write down the Henderson Hasselbalch equation. Explain the role of kidney in the maintenance of acid base balance in our body. 1+6
   2. Name the components of the electron transport chain with the help of a diagram. Explain how the electron flows from the NADH+H⁺ to the molecular oxygen through the different components of ETC. 2+5
   3. State different types of transport of molecule across biomembrane. Mention characteristics of Carrier Mediated Transport. Differentiate between Primary active transport with that of secondary active transport. 2+2+3

Group C

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3. Write a brief account on any four of the following: 4 x 3
   1. Phospholipases.
   2. Peptide bond.
   3. RBC Group Antigen.
   4. Thin layer Chromatography.
   5. Glycosides.

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Group D

4. Explain the following statements: 4x3
   1. DNA is alkali resistant, whereas RNA is alkali labile.
   2. Methotrexate inhibits the formation of Tetrahydrofolate from folic acid.
   3. F_oF₁ ATPase give rise to ATP synthesis in intact mitochondria.

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   4. HbF has more affinity towards oxygen than HbA.

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