The West Bengal University of Health Sciences
MBBS 1st Professional Examination (New Regulation), June 2022
Subject: Biochemistry
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Paper: 1
Attempt all questions. The figures in the margin indicate full marks.
Full Marks: 100
Time: 3 hours
- a) A 60 year old man was brought to the hospital with complaints of severe chest pain, breathlessness and vomiting. He could reach the near by referral hospital in town 5 hours after the onset of chest pain. His blood was immediately drawn in casualty and result are as follows:
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Investigation in serum
Creatine kinase (CK) - 400 U/L
CK-MB-100 U/L
AST (Aspartate transaminase) - 70 U/L
LDH(Lactate dehydrogenase) - 380 U/L--- Content provided by FirstRanker.com ---
What is your provisional diagnosis ?
Explain the points supporting your diagnosis
Write down the clinical significance of different isoenzymes. 2+8+5
b) Describe the Singer and Nicolson model of biomembrane. Explain the role of phospholipids and cholesterol in maintenance of membrane fluidity. Explain how cystic fibrosis is caused due to defective ion transport through biomembranes. 5+5+5 - Describe the hexose monophosphate shunt and add a note on its significance. 6+4
- a) Define active site of an enzyme. What are different factors that affect enzyme activities? Compare between Competitive and non-competitive inhibition. Define marker enzymes with examples. 4+4+3+2
- Describe the sources of ammonia in the body and its need to be transported to liver from various organs and explained the mechanise of its toxicity. 2+4+4
- Write a short notes on the following: 2x5
a) Role of a physician in health care system.
b) Lesch nyhan syndrome. - Explain the following statements: 5x4
a) Benedict's test in urine can give positive results inspite of normal blood glucose concentration.
b) Prostacyclins & Thromboxanes exert opposing actions.
c) Alkaptonuria is associated with generalized pigmentation of connective tissues.
d) Oral rehydration solution contains glucose.--- Content provided by FirstRanker.com ---
e) Coenzymes are called Co-substrates.
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- Choose the correct option for each of the following: 10x1
i) Which of the following statements regarding the role of HCO3/H2CO3 buffer system is NOT TRUE:
a) It is an open buffer system in human--- Content provided by FirstRanker.com ---
b) It is the most abundant extracellular buffer
c) It is regulated by the kidney only
d) Carbonic anhydrase plays an important role in maintaining it.
ii) Which one of the following statements is true for the enzyme glucokinase?
a) Its an important enzyme related to the glycogen synthesis pathway.--- Content provided by FirstRanker.com ---
b) It is an important enzyme glycolytic pathway in the liver.
c) It is an important enzyme glycolytic pathway in the skeletal muscles.
d) It is an important enzyme related to the glycogen breakdown pathway.
iii) All the following enzymes are ligases except
a) Glycogen Synthase.--- Content provided by FirstRanker.com ---
b) Glutamine synthetase.
c) Acetyl CoA Carboxylase.
d) PRPP synthetase.
iv) The following substance acts as satiety signal for lipids
a) Apo A.--- Content provided by FirstRanker.com ---
b) Enterostatin.
c) HCL.
d) Gastrin.
v) Which of the following amino acids function as a chain breaking amino acid in protein folding?
a) Glycine.--- Content provided by FirstRanker.com ---
b) Proline.
c) Glutamate.
d) Valine
vi) Which of the following disorder is caused by deficiency of muscle glycogen phosphorylase:
a) Von-Gierke's disease.--- Content provided by FirstRanker.com ---
b) Pompe's disease.
c) Her's disease.
d) McArdle's disease.
vii) Role of cyanide in ETC is
a) Allosteric inhibition.--- Content provided by FirstRanker.com ---
b) Competitive inhibition.
c) End product inhibition.
d) Non competitive inhibition.
viii) Which of the following base is not found in RNA ?
a) Thymine.--- Content provided by FirstRanker.com ---
b) Guanosine.
c) Adenine.
d) Cytosine.
ix) The wonder molecule nitric oxide is synthesized from
a) Histidine.--- Content provided by FirstRanker.com ---
b) Lysine.
c) Arginine.
d) Methionine.
x) Flipped pattern of LDH iso enzyme is seen in
a) Myocardial infarction.--- Content provided by FirstRanker.com ---
b) Liver disease.
c) Peptic ulcer.
d) Infectious disease.
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