ANATOMY
HNF
SN
- Digastric Triangle
- Nasal Septum*
- Thyroid Gland – Blood Supply*, Applied Anatomy
- Carotid Sheath
- Muscles of Mastication
- Cavernous Sinus*
- Carotid Triangle
- Little's Area of Nose – Clinical Significance
- Lateral Rectus Muscle of Eyeball
- Hyoid Bone
- Palatine Tonsil – Applied Anatomy*
- Dangerous Area of Face
- Nasal Meatus
- Tongue - Applied Anatomy
- Ansa Cervicalis
- Falx Cerebri
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LAQ
- Parotid Gland****
- Tongue**
- Scalp
- Thyroid Gland**
- Middle Ear
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Upper Limb
SN
- Cubital Fossa**
- Klumpke's Paralysis*
- Abduction at Shoulder Joint
- Rotator Cuff
- Carpal Tunnel Syndrome**
- Mammary Gland - Lymphatic Drainage****, Applied Anatomy
- Erb's Paralysis*
- Pronation and Supination
- Clavipectoral Fascia
- Clawhand - Features and Causative Factors
- Musculocutaneous Nerve
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LAQ
- Shoulder Joint***
- Ulnar Nerve*
- Brachial Plexus
- Cubital Fossa
- Axillary Artery
- Mid-Palmar Space
- Radial Nerve
- Median Nerve
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Thorax
SN
- Thoracic Duct
- Root of Right Lung
- Azygous Vein
- Arch of Aorta
- Typical Intercostal Nerve
- Bronchopulmonary Segments of Left Lung
- Left Coronary Artery*
- Bronchopulmonary Segments – Applied Anatomy*
- Coronary Sinus
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LAQ
- Bronchopulmonary Segments
- Right Atrium**
- Arch of Aorta**
- Superior Mediastinum
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Neuroanatomy
SN
- Medial Medullary Syndrome
- Floor of Fourth Ventricle**
- Circle of Willis
- T.S. Medulla Oblongata – Pyramidal Decussation
- T.S. Midbrain - Superior Colliculus Level*
- Corpus Callosum**
- Brown Sequard Syndrome
- Inferior Cerebellar Peduncle*
- T.S. Spinal Cord – Cervical Level
- Internal Capsule
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LAQ
- Glossopharyngeal Nerve*
- Superolateral Surface of Cerebrum**
- Internal Capsule*
- Pons
- Occulomotor Nerve
- Midbrain
- Functional Areas in Frontal Lobe
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Abdomen & Pelvis
SN
- Anal Canal – Applied Aspect
- Portacaval Anastomosis* – Applied Anatomy
- Inguinal Hernia* – Direct, Indirect
- Male Urethra
- Caput Medusae
- Uterus - Supports*, Applied Anatomy
- Stomach Bed*
- Meckel's Diverticulum*
- Inguinal Canal
- Ischiorectal Fossa*
- Lesser Omentum*
- Rectus Sheath
- Inferior Vena Cava
- Superficial Perineal Pouch
- McBurney's Point
- Interior of Urinary Bladder
- Umbilicus - Anatomical and Clinical Importance
- Perineal Body
- Contraception – Anatomical Basis
- Anterior Relations of Right Kidney – diagram
- Hysterosalphingography
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LAQ
- Pancreas**
- Ischiorectal Fossa
- Kidney
- Uterine Tube
- Testes
- Extra-Hepatic Biliary Apparatus*
- Rectus Sheath
- Urinary Bladder*
- Prostate**
- Suprarenal Gland*
- Uterus
- Stomach**
- Ovary*
- Duodenum – 2nd Part
- Anal Canal*
- Diaphragm
- Inguinal Canal*
- Internal Iliac Artery
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Lower Limb
SN
- Sartorius*
- Medial Longitudinal Arch* – Factors Maintaining
- Gluteus Maximus
- Foot Drop* - Anatomical Basis
- Femoral Sheath
- Femoral Canal*
- Popliteus**
- Inversion and Eversion* - Inverters and Everters with Nerve Supply
- Superficial Inguinal Lymph Nodes
- Femoral Hernia
- Longitudinal Arches of Foot
- Gastrocnemius
- Great Saphenous Vein
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LAQ
- Hip Joint*
- Venous Drainage of Lower Limb
- Intra-Articular Structures of Knee Joint*
- Sciatic Nerve
- Femoral Triangle
- Knee Joint**
- Popliteal Fossa*
- Lateral Longitudinal Arch of Foot
- Veins of Inferior Extremity
- Structures Under Gluteus Maximus - diagram
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General Anatomy
- Synovial Joint** - diagram, classification, examples
- Classification of Fibrous Joint
- Sesamoid Bone
- Cartilaginous Joint - classification, example
- Epiphysis
- Secondary Cartilaginous Joint
- Pivot Joint
- Blood Supply of Long bone
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Histology
- Adrenal**
- Muscular Artery*
- Stratified Squamous Epithelium
- Testes**
- Ovary
- Compact Bone
- Spleen**
- Kidney
- Lymph Node
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Embryology
- Notocord
- Mesonephric Duct
- Primitive Streak
- Phases of Fertilisation
- Pancreas*
- Neural Tube Defects
- Vitello-intestinal Duct
- Urinary Bladder
- Descent of Testes*
- Developmental Anomalies of Kidney
- Rotation of Gut
- Fate and Derivatives of Yolk Sac
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Genetics
- Barr Body*
- Lyons Hypothesis
- Turner's Syndrome*
- Karyotyping*
- Monosomy of Sex Chromosome
- Down's Syndrome*
- Structural Chromosome Abnormalities
- Autosomal Dominant Inheritance
- Structural and Numerical Chromosome Abnormalities with example
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PHYSIOLOGY
Paper 1
CVS
SN
- Circulatory Shock - define, classify, stages, physiological principles of management
- Connections of Unipolar and Bipolar Limb Leads while regarding ECG
- ECG Trace in Lead II* - draw, label, mark intervals
- CNS Ischemic Response
- Baroreceptor Reflex Mechanism
- Ventricular Diastole - events
- Properties of Cardiac Muscle*, Ionic Basis of Autorhythmicity in SA Node, Why Heart Muscle Cannot be Tetanized
- Role of JGA in Regulation of Blood Pressure
- Coronary Circulation - peculiarities, Angina Pectoris
- Renin-Angiotensin Mechanism
- Heart Block - enlist types, explain AV Nodal Block
- Heart Rate - explain increase in heart rate in muscular exercise
- Fick Principle
- ECG - diagram, Bipolar Limb Leads
- Venous Return
- Factors Affecting Stroke Volume
- Effect of Isotonic Exercise on Blood Pressure
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LAQ
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- Cardiac Cycle** - define, pressure and volume changes in left ventricle*, diagram; Third and Fourth Heart Sound*
- Coronary Circulation - physiologic anatomy, factors affecting, special features; Angina Pectoris
- Blood Pressure - define, long-term regulation
- Circulatory Shock** - define, classify; Compensatory Stage of Circulatory Shock, Progressive Stage, Hemorrhagic Shock Physiological Basis of its Management
- ECG - define; Explain ECG in Lead II - diagram; Heart Block
- Mean Arterial Blood Pressure - define, enumerate mechanisms regulating; Baroreceptor Mechanism - describe
- Regulation of BP - classify mechanism; Short Term Regulation
- Define - Stroke Volume, Cardiac Output, Cardiac Index, Stroke Volume Index; Factors Affecting Cardiac Output
- Heart Rate - define, factors affecting and regulating
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GIT
SN
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- Functions of Bile Salts**, Composition
- Peptic Ulcer*** - etiology, physiological basis of treatment
- Regulation of Gastric Emptying*
- Phases of Deglutition - enlist, Pharyngeal Phase** - explain
- Mechanism of Secretion of HCl by Parietal Cells, Gastric Glands
- Movement of Small Intestine, Peristaltic Rush
- Mechanism of Secretion of HCI*
- Importance of Deglutition Reflex
- Movement of Large Intestine, Defecation Reflex*
- Enumerate GIT Hormones, Note on Gastrin, CCK
- Regulation of Gastric Motility
- Absorption of Fat
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LAQ
- Deglutition, Achalasia Cardia
- Pancreatic Juice - composition, function, regulation of secretion
- Gastric Glands - enumerate, secretion, function; Treatment of Peptic Ulcer*
- Gastric Juice - composition; HCl Secretion - mechanism, factors regulating***
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Endocrine System
SN
- Functions of Insulin
- Diabetes Mellitus and Insipidus* - compare and contrast
- Parathyroid hormone - functions, regulation
- Growth Hormone* - metabolic action
- Insulin Secretion - factors increasing, effect in promoting growth
- Diabetes Insipidus, Cushing Syndrome
- Tetany, Signs of Tetany, Treatment
- Cushing Syndrome*, Clinical Features
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LAQ
- Glucocorticoids - regulation of secretion, mechanism of action, function, effect of deficiency
- Thyroid Hormone Synthesis and Release - enumerate steps, diagram; Anti-Thyroid Drugs - action
- Hormonal Regulation of Growth*, Dwarfism, Pituitary & Thyroid Dwarf Differences
- Thyroid* - synthesis, mechanism of action, regulation of secretion, function; Endemic Goitre, Hypothyroidism
- Calcium* - importance, regulation; Tetany, Osteoporosis
- Adrenal Cortex - enumerate hormones; Factors Regulating Secretion of Aldosterone
- Anterior Pituitary - enumerate hormones secreted; Physiological Actions of Growth Hormone*, Dwarfism
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Reproductive System
SN
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- Indicators of Ovulation, Clinical Significance
- Methods of Contraception*** - temporary, Physiological Basis of Oral Contraceptives, Safe Period
- Spermatogenesis* - describe stages, enlist factors affecting it
- Physiological Changes in Pregnancy
- Maternal Changes in Last Trimester of Pregnancy
- Mechanism of Ovulation, Contraception - rhythm method
- Menstrual Cycle - phases
- Circulatory Changes at Birth
- Menstrual Cycle - hormonal and uterine changes, diagram
- Parturition - explain, role of oxytocin
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LAQ
- Menstrual Cycle - phases, hormonal control
- Cyclical Changes in Uterus during Reproductive Life, Its Hormonal Regulation
RS
SN
- Oxygen-Hemoglobin Dissociation Curve** - draw, label, factors affecting, Bohr's Effect, factors shifting curve to right, what is P50, role of 2,3-BPG
- Characteristics of Pulmonary Circulation
- Acclimatization to High Altitude - enumerate physiological changes, significance of changes
- Heat Stroke
- Heat Loss*** - enumerate methods, mechanism, mechanism of sweating
- Peripheral Chemoreceptors - characteristics, functions
- Factors Affecting Composition of Alveolar Air
- Oxygen Debt*
- Hypoxia*** - define, classify, describe Hypoxic Hypoxia
- Ways of Heat Loss, Heat Stroke
- Surfactant* - functions, note on RDS
- Transport of Carbon dioxide, Haldane Effect
- Response of Body when exposed to Extreme Cold**, Hypothermia, Use of Induced Hypothermia
- Effect of Exercise on Respiration, what is VO2 max
- Explain Work of Breathing*, Applied Importance, Enumerate Muscles of Respiration
- Functional Residual Capacity - physiological significance
- Acclimatization to High Altitude - various changes, Acute Mountain Sickness
- Haldane Effect
- Role of Hypothalamus in Temperature Regulation
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LAQ
- Neural Regulation of Breathing**, Periodic Breathing, Ondine's Curse*
- Transport of CO2, Haldane Effect, Its Significance
- Lung Compliance* - describe, factors affecting; Hyaline Membrane Disease
- Respiratory Membrane* - describe, factors affecting gaseous exchange; Principle of CO Method
- Pulmonary Ventilation - mechanism; Positive Pressure Breathing
- Oxygen Transport - describe method
- Chemical Control of Respiration
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Paper 2
CNS
SN
- Receptor** - enumerate properties, any two properties in detail
- Referred Pain*, Enumerate Different Types of Pain
- Lesions of Upper and Lower Motor Neuron
- Functions of Basal Ganglia*
- Middle Ear - functions
- Parkinsonism**
- i. Pathway of Proprioceptive Sensations from Periphery to Cortex
ii. Sensory Ataxia - define, difference from Cerebellar Ataxia - REM Sleep**, Narcolepsy
- Muscle Spindle* - diagram, function
- Speech
- Descending Pain Inhibiting System
- Aphasia - define, different types
- Different types of Pain, Transmission of Pain through Neospinothalamic Pathway
- Ascending Tracts - name; Labelled Diagram of Pain Pathway
- Lower Motor Neuron - define, features of LMN paralysis
- Important Areas of Frontal Lobe - diagram, Functions of Prefrontal Lobe
- Sensory Receptors, Adaptation and Intensity Discrimination
- Fast and Slow Pain
- Memory - define, types; Alzheimer's
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LAQ
- Ascending Tracts** - enumerate;
- Dorsal Column System - origin, course, termination; Phantom Limb
- Pathway for Touch Sensation - describe
- Pathway for Line Touch Sensation, Law of Projection
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- Muscle Spindle - diagram; Role of Stretch Reflex in Controlling Muscle of Tone
- Functions of Hypothalamus** - enumerate, explain any three in detail
- Basal Ganglia* - connections, functions; Parkinsonism - clinical features
- Cerebellum** - functions, connections, applied importance
- Complete Transaction of Spinal Cord - effects
- Pyramidal Tracts* - origin, course, termination, function, applied
- Lobes of Neocortex - functions
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Renal Physiology
SN
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- JGA - diagram, functions**
- Countercurrent Multiplier Mechanism
- Role of Kidney in Acid-Base Balance
- i. Transport Maximum - define
ii. Mechanism of Glucose Reabsorption in Renal Tubules - GFR - define, factors***; Tubular Glomerular Feedback, Glomerular Tubular Balance
- Cystometrography
- PCT - functions
- Countercurrent Mechanism
- Innervation of Urinary Bladder, Micturition Reflex
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LAQ
- GFR** - define, enumerate factors affecting, methods of measurement, regulation
- Physiology of Micturition*; Cystometrogram
- DCT - functions
- Milleu Interior - define; Role of Kidney in Maintaining Osmolarity of Body Fluid
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Special Senses
SN
- Visual Pathway* - diagram, lesions, heteronymous hemianopia
- Dark Adaptation** - define, significance
- Organ of Corti
- Accommodation of Eye*, Accommodation Reflex* - describe, significance; Presbyopia
- Place Principle, Explain Role of Basilar Membrane in Perception of Sound*
- Colour Vision
- Impedance Matching, Causes of Conductive Deafness
- Olfactory Pathway
- Errors of Refraction; Myopia, Astigmatism - features, correction
- Taste Sensation Pathway, Basic Modalities of Taste, Types of Papillae
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LAQ
- Mechanism of Hearing - describe; Pitch Discrimination
- Colour Vision - mechanism; Colour Blindness
- Accommodation - define, mechanism, neural pathway; Presbyopia
- Photochemistry of Vision*, Dark Adaptation
- Middle Ear - role; Organ of Corti
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Nerve-Muscle Physiology
SN
- Excitation-Contraction Coupling
- Action Potential - define, compare ionic basis of large myelinated nerve fibre and SAN**
- NMJ - diagram*, Myasthenia Gravis, End Plate Potential - define, generation
- Properties of Never Fibres
- Factors Regulating Force of Skeletal Muscle Contraction, Motor Unit - define
- Refractory Period
- Sarcotubular System
- Red Muscle and Pale Muscle, Isotonic and Isometric Contraction
- Saltatory Conductions, Factors Affecting Conduction Velocity
- Compare, Contrast AP and Excitatory Post Synaptic Potential Neurons
- RMP - define, explain ionic basis of RMP in nerve fibre
- Molecular Basis of Muscle Contraction
- Neuron - diagram, Nerve Impulse - define
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LAQ
- Genesis of Action Potential - describe. Properties of AP - enumerate
- Sarcomere* - define, diagram; Sliding Filament Theory - explain
- RMP - define, factors contributing; Phases of AP
- NMJ* - diagram; Describe Neuromuscular Transmission; Myasthenia Gravis*
- Synaptic Transmission - mechanism; Synapse - two properties
- Molecular Basis of Skeletal Muscle Contraction*
- Muscle Tone - define, regulation
- i. RMP - define
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ii. Ionic Basis for Development of RMP and AP
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Blood
SN
- Intrinsic Pathway of Coagulation
- Role of B Lymphocytes
- Blood Group - classify, Erythroblastosis Foetalis
- Mismatched Blood Transfusion
- Functions of Plasma Proteins*
- Immunity* - define, primary and secondary immune response and its role in vaccination, role of T cells
- Landsteiner's Law, Importance of Rh Blood Group*
- CD4 Cells
- Platelets - normal count, functions
- Erythroblastosis foetalis - features, treatment
- Bleeding Time, Clotting Time - define, Intrinsic Pathway - describe
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LAQ
- Coagulation - define, flowchart; Bleeding and Clotting Disorders - differences, examples
- Immunity* - define, classify; Cell Mediated Immunity; Humoral Immunity, Vaccination
- Clotting - define; Mechanism of Blood Coagulation - flowchart; Anticoagulants - name
- WBC - classify, morphology, function
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General Physiology
SN
- Homeostasis** - define, compare between feedback systems
- Transport Mechanism Across Cell Membrane, Secondary Active Transport*
- Osmosis
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LAQ
- Transport Mechanism - describe, examples
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BIOCHEMISTRY
Paper 1
Protein Metabolism
SN
- Metabolism of Tyrosine (pg 345)
- Biogenic Amines (pg 375)
- Metabolism of Glycine (pg 341)
- Alkaptonuria (pg 352)
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LAQ
- Inborn Errors of Metabolism of Tyrosine* and Phenylalanine
- Formation and Fate of Ammonia**
- Urea Cycle and Abnormalities***
- Alkaptonuria - Biochemical Basis, Tests for Diagnosis
- Glycine - synthesis, inhibition, specialised products formed
- Transamination, Deamination, Ammonia Toxicity
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Nucleotide Metabolism
SN
- Purine Salvage Pathway* (pg 391)
- Hyperuricemia (pg 394)
- Gout** (pg 394)
- Catabolism of Purines (pg 392)
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Hemoglobin
SN
- Hemoglobinopathies and examples (pg 203)
- Abnormal Hemoglobin** - changes in AA sequence (pg 202)
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LAQ
- Catabolism of Heme*, Hemolytic Jaundice
- Formation and Fate of Bilirubin; Jaundice
- Biosynthesis and Degradation of Heme
- Heme - biosynthesis, regulation*; Intermittent Porphyria
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Vitamins
SN
- Coenzymes of Thiamine of Pyridoxine - two biochemical functions of each
- Functions of Folic Acid (pg 150)
- Deficiency Manifestation of Vitamin A (pg 118)
- Coenzyme Function of Folic Acid and B12 (pg 150)
- Wald's Visual Cycle (pg 129)
- Activation of Cholecalciferol, Justification as a Hormone (pg 124)
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LAQ
- Vitamin D
- Vitamin A**
- Vitamin B12 and Folic Acid
- Vitamin C
- Thiamine*
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Enzymes
SN
- Isoenzymes and Clinical Application*** (pg 109)
- Enzymes and Isoenzymes in Myocardial Infarction** (pg 112)
- Enzymes of Diagnostic, Analytic and Therapeutic Importance* (pg 105)
- Km Value (pg 88)
- Activation Energy of Enzyme - E-S Complex (pg 98)
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LAQ
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- Enzymes - definition, factors affecting enzyme activity*
- Enzyme Inhibition - Competitive and Non-Competitive
- Enzymes - classification, examples, Isoenzymes
- Types of Enzyme Inhibitors
Biological Oxidation
SN
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- Substrate Level Phosphorylation (pg 224)
- Oxidative Phosphorylation*** and Thermogenin (pg 228)
- Malate Aspartate Shuttle* (pg 234)
- Inhibitors of ETC (pg 232)
- Uncouplers of Oxidative Phosphorylation (pg 233)
- Difference between Oxidative and Substrate Level Phosphorylation
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LAQ
- Explain ETC, Mention Sites of
- ATP Synthesis and Inhibitors of ETC**
- Oxidative Phosphorylation
- Explain ETC, Inhibitors and Uncouplers of Oxidative Phosphorylation
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Molecular Biology
SN
- Genetic Code*** (pg 551)
- Mutation* - Causes and Types (pg 535)
- Recombinant DNA Technology Applications
- Reverse Transcription (pg 550)
- DNA Replication (pg 524)
- PCR (pg 534)
- Lac Operon (pg 557)
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LAQ
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- Protein Biosynthesis* and Inhibitors, Regulation
- DNA Replication, Two Inhibitors of Replication
- Genetic Code- salient features, Wobble's Hypothesis
- Transcription, Post-Transcriptional Modification, Two Antibiotics Inhibiting the process
Proteins
SN
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- Biologically Important Peptides* (pg 65)
- Secondary and Tertiary Structure of Proteins** (pg 56)
- tRNA And Its Functions*** (pg 81)
- Secondary Structure of Protein (pg 56)
- Functional Classification of Proteins (pg 63)
- Conjugated Proteins (pg 64)
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Nucleotides
SN
- Four Biochemical Functions of Nucleotides*
Free Radicals and Antioxidants
SN
- Antioxidants (pg 655)
- Antioxidant Enzymes*, Vitamins and Minerals
- Free Radicals and Antioxidants
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Nutrition
SN
- Explain the Role of Dietary Fibres* (pg 508)
- BMR - definition, factors (pg 504)
- Protein Energy Malnutrition*** (pg 516)
- Kwashiorkor* - Biochemical Alterations and Treatment (pg 516)
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Plasma Proteins
SN
- Immunoglobulin - diagram, describe any one Ig in detail* (pg 186)
- Functions of Albumin (pg 183)
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Paper 2
Carbohydrate Metabolism
SN
- Significance of HMP Shunt* (pg 270)
- Rapaport Leubering Cycle, Significance (pg 251)
- Glycogen Storage Disease* - enzyme defects, clinical manifestation (pg 269)
LAQ
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- Glycolytic Pathway in Erythrocytes, Significance, Difference from Glycolysis (pg 251)
- Glycogenolysis, Regulation, Glycogen Storage Diseases* (pg 265)
- TCA Cycle, Amphibolic Nature* (pg 252)
- HMP Shunt*, Significance (pg 270)
- Metabolism of Glycogen, Hormonal Regulation* (pg 263)
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Lipid Metabolism
SN
- Cholesterol - biomedical importance (pg 315)
- Cholesterol - metabolism, function (pg 309)
- Lipoproteins* (pg 317)
- Fatty Liver* and Lipotroptic Factors* (pg 322)
- Ketosis (pg 296)
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LAQ
- Cholesterol Synthesis*** - name regulatory enzyme, normal level, functions, explain role in Atherosclerosis (pg 308)
- Ketosis, Synthesis and Fate of Ketone Bodies (pg 293)
- Beta Oxidation of Palmitic Acid, Regulation, Energetics** (pg 290)
- Roles of LDL, HDL in Cholesterol Transport, Role in Atherosclerosis (pg 320, 326)
- Fate of Acetyl CoA, Fatty Acid Synthesis (pg 297)
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Mineral Metabolism
SN
- Regulation of Serum Calcium Level (pg 407)
- Role of Calcium as Second Messenger (pg 405)
- Absorption of Iron (pg 414)
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LAQ
- Plasma Calcium Level - hormonal regulation, function, deficiency manifestation (pg 407)
- Iron* (pg 414)
- Calcium* (pg 404)
- Calcium and Phosphorus (pg 404, 409)
- Copper and Zinc (pg 416, 419)
- Iron and lodine (pg 414, 418)
- Factors Influencing Calcium Absorption, Functions (pg 404)
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Integration of Metabolism
SN
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- Short Term Starvation - metabolic changes (pg 383)
- Biochemical Changes in Starvation** (pg 383)
- Most Severe Phase of Starvation - biochemical changes (Pankaja - pg 276)
LAQ
- Starvation Metabolism* (pg 383)
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Acid-Base Balance
SN
- Buffers** (pg 475)
- Role of Kidney in Acid Base Balance (pg 477)
- Any Two Buffer Systems (pg 475)
- Metabolic Acidosis*, Its Compensation (pg 4
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