ALCOHOL METABOLISM.
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WALKER SAID :- ALCOHOL CAN BE; FOOD, DRUG OR POISON DEPENDING ON AMOUNT.
IN SMALL QUANTITY GOOD FOR HEALTH.
HOWEVER SLOWLY THE CONSUMPTION INCREASES CAUSING HARMFUL EFFECTS.
90% ABSORBED IN STOMACH, INTESTINE 2-10% only EXCRETED.
ALCOHOL --ALCOHOL DEHYDROGENASE--> ACETALDEHYDE
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BESIDE ADH, MICROSOMAL ETHANOL OXIDISING SYSTEM (MEOS), IS ALSO RESPONSIBLE FOR METABOLISM.
ACETALDEHYDE --ALDEHYDE DEHYDROGENASE--> ACETIC ACID ENTERS KREB CYCLE.
SINCE ACTIVITY of ALDEHYDE DEHYDROGENASE IS LOW; ACETALDEHYDE STARTS ACCUMULATING.
DISULFIRAM, A DRUG IS USED FOR TREATMENT of ALCOHOLISM, INHIBITS ALDEHYDE DEHYDROGENASE.
#) BIOCHEMICAL CHANGES IN ALCOHOLISM.
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BOTH DEHYDROGENASE INVOLVES CONSUMPTION of NAD+ & PRODUCES HIGH NADH + H+ Ratio.
SOME METABOLIC ALTERATION:-
1) HIGH NADH FAVOURS CONVERSION of PYRUVATE To LACTATE WHICH CAUSES "LACTIC ACIDOSIS".
2) HYPOGLYCEMIA, Due To DECREASED PYRUVATE & OXALOACETATE.
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3) CITRIC ACID IS IMPAIRED; SINCE ACETYL COA ACCUMULATES HYPER LIPIDEMIA!
KETO GENESIS CHOLESTEROL SYNTHESIS FATTY ACID
4) ? Serum URIC ACID, DUE To LESS EXCRETION.
5) ACETALDEHYDE INTERFERES WITH FUNCTI. of NEURO TRANSMITTER, CAUSING NEUROLOGICAL DEPRESSION.
6) CAUSES, HEADACHE, NAUSEA, TACHYCARDIA, REDUCED BP etc.
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#) EFFECTS of CHRONIC ALCOHOLISM:
ASSOCIATED WITH CIRRHOSIS of LIVER, NEURODEGENERATIVE CHANGES CARDIOMYOPATHY DIURESIS IMPOTENCE etc.
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This download link is referred from the post: MBBS 2025 Lecture Notes for all subjects