GASTRIC JUICE
Composition
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- 0.5% Solid [Inorganic
- 99.5% Water Organic
Intro
- Acidic In Nature
- 1200 ml/day to 1500 ml/day
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Digestive function = Enzyme Based.
- Mainly acts on Protein. [Renin & Pepsin]
- other Enzymes
- Gastric lipase.
- Urease.
- Gastric amylase.
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PEPSIN
- Secreted as Pepsinogen [Inactivated form]
- Active form (PEPSIN) by HCL.
- Converts, Protein -> Peptones.
- Proteose
- Polypeptides.
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Gastric lipase
- Weak as compared to Pancreatic lipase.
- Butter -> fats + Glycerol
- Becomes Inactive below 2.5
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UREASE
- Gelatin -> Collagen
UREASE
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- Urea -> Ammonia
Gastric amylase
- degrades Starch
Rennin
- Curdles MILK.
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HEAMOPOITIC FUNCTION
- Castle Intrinsic factor released by gastric glands
- Very Important for absorption of Vitamin B12 [Extrinsin factor]
- Vitamin B12 is Very Important for Erythropoiesis.
- defect in it's absorption Causes PERNICIOUS ANEMIA.
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Mucus
- Secreted from Neck cells of Gastric Glands has 3 functi.
- Prevents stomach from Mechanical Injury.
- from Acidic HCL.
- digestive action of Pepsin
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HCI
- kills harmful pathogen
- Required for Activation of various Enzymes.
- eg) Pepsinogen -> Pepsin.
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REGULATION
- Stimulating
- SOMATOSTATIN
- HISTAMINE
- ACETYLCHOLINE
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CEPHALIC PHASE: Only nervous
Conditioned reflex
- Sight, smell, thought of and hearing about food
Unconditioned reflex
- Presence of food in mouth
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GASTRIC PHASE: Nervous and hormonal
Bolus in stomach
INTESTINAL PHASE: Mostly hormonal
Chyme in intestine
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This download link is referred from the post: MBBS 2025 Lecture Notes for all subjects
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