Riboflavin
Vit - B2.
Garvit Jain
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Tele - @senty-dr
Provided.
Riboflavin (Vitamin B2) (Redox Rxns)
Chemically identical - lactoflavin (milk)
Hepatoflavin (liver)
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Ova Ovoflavin (eggs)
Riboflavin through its coenzymes takes part in variety of cellular oxidation - Reduction Rxns.
Riboflavin is 6-7 dimethyl isoalloxazine to which Ribitol is attached.
6-7 dimethyl isoalloxazine + Ribitol
Riboflavin + P (*) Coenzymes of B2 -
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FMN + AMP FMN = Flavin mono nude
FAD FAD = Flavin Adenosine Dienucleotide
Biochemical functions produces energy by
FMN FAD Flavin coenzymes Redox Rxns
Functional unit of both : Isoalloxazine (accepts 2H)
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+FMN + H2 ? FMNH2
/FAD+ ? /FADH2
Enzymes that use Flavin coenzymes flavo-proteins.
Coenzymes Apcoenzyme
(Prosthetic) (Protein)
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Joined by covalent / non covalent Bonds.
Metallo / flavoproteins = Flavo proteins + Metal.
#) FAD dependent Enzymes -
1) Carbohydrate Metabolism -
(a) Pyruvate Acetyl CoA
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Pyruvate dehydrogenase
(b) a Ketoglutarate Succinyl CoA
a Ketoglutarate dehydrogenase
(c) Succinate Fumarate
Succinate dehydrogenase
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2) Lipid Metabolism-
a) Acyl CoA a,ß unsatu, acyl CoA
Acyl CoA dehydrogenase
3) Protein
4) Glycine Glyoxylate + NH3
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glycine oxidase
4) D amino acid a Keto acid + NH3
D Amino acid oxidase
4) Purine Meta.
Xanthine Uric acid
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Xanthine Oxidase
H) FMN -11-
L amino acid oxidase a keto acid + NH3
Recommended Dietary Allowance = 1.2 - 1.7 mg / day
Pregnant / lactating f = 1.4 - 2.2 mg/day
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Sources Meat; Milk products, Milk, eggs, liver, kidney
Cereals, fruits, vegetables
Deficiency symptoms -
(i) Cheilosis (fissures at the corner of mouth).
(ii) Glossitis (Soft purple tongue)
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(iii) Dermatitis.
(iv) Stomatitis
Defi. is generally uncommon but mainly found with other Vitamin defi
Chronic Alcoholics are more chronic Vit B2 def.
Assay of enzyme Glutathione Reductase in RBC is useful in assaying Riboflavin deficiency.
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This download link is referred from the post: MBBS 2025 Lecture Notes for all subjects
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