Download Kashmir University 2nd Year MBBS 234081 Pharmacology Paper II 2022 Question Paper

Total No. of Questions - 25] [Total No. of Printed Pages-8

M.B.B.S. II Professional Examination

MB-II/12(R)

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234081

Pharmacology

Paper - II

(New Course)

Time Allowed: 3 Hours Maximum Marks : 100

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1. Section-1 (MCQ's).
   ALL Questions are compulsory. Each question carries
   ONE mark. Tick the right answer. (20 Marks)
2. Section-2
   Attempt ALL questions write legible & precise answers.
   

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   (80 Marks)

SECTION-I

Note :- ALL Questions are compulsory. Each question
carries ONE mark. Tick the right answer.

(Maximum Marks=20)

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Multiple Choice Questions.

1. Which of the following is a fourth generation
   cephalosporin:-
   1. Cefipime
   2. Cefotaxime
   3. Cefpodoxime

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   4. Ceftazidime

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2. All of the following are typical anti-psychotic drugs
   except:
   1. Trifluperazine

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   2. Chlorpromazine
   3. Haloperidol
   4. Olanzapine
3. Which of the following antiemetic drug is a 5-HT,
   

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   antagonist:-
   1. Domperidone
   2. Ondansetron
   3. Dronabinol
   4. Promethazine

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4. Vaccine commonly administered as post exposure
   prophylaxis is:-
   1. Rabies
   2. Hepatitis
   3. MMR
   4. HIB

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5. Antibiotics used in acne are all except:-
   1. Clindamycin
   2. Azithromycin
   3. Nadifloxacin
   4. Amoxicillin

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6. TNF a inhibitor used in psoriasis is :-
   1. Etanercept
   2. Efalizumate
   3. Tafacitinab
   4. Apremilast

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7. Dimercaprol is used in poisoning due to all of the
   following except:-
   1. Asrenic BAL
   2. Mercury
   3. Copper

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   4. Iron
8. All of the following are features of vitamin A
   deficiency except:
   1. Hyperkeratosis
   2. Xerophthalmia

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   3. Swelling of gums
   4. Increase susceptibility to infection
9. Drug of choice for precocious puberty:-
   1. Cyproterone
   2. Danazol

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   3. Medroxyprogesterone
   4. GnRH agonist

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10. Which of the following drug is an inhibitor of iodine
    

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    trapping by thyroid :-
    1. Methimazole
    2. Carbimazole
    3. Potassium perchlorate
    4. Prophylthiouracil

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11. Which of the following insulin preparation is given
    by both SC and IV route:-
    1. Isophane Insulin
    2. Regular insulin
    3. Lente insulin
    4. Semilente Insulin

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12. The antagonist of choice in opioid poisoning is :-
    1. Naloxone
    2. Natrexone
    3. Fentanyl
    4. Nalorphine

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13. Corticosteroid with significant mineralocorticoid
    activity is :-
    1. Fludrocortisone
    2. Triamcinolone
    3. Betamethasone

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    4. Dexamethasone
14. Most effective anti tubercular drug for rapidly
    growing bacteria is :-
    1. Rifampicin
    2. Ethambutol

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    3. Isoniazid
    4. Pyrazinamide
15. Non Neucleoside Reverse transcriptase inhibitor
    (NNRT) used to prevent vertical transmission:-
    1. Nevirapine

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    2. Efavirnez
    3. Dellavirdine
    4. Etravirine
16. All of the following are the adverse effects of
    

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    Aspirin except:-
    1. Angioedema
    2. Salicyclism
    3. Respiratory alkaloses
    4. Patent ductus arteriosus

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17. All of the following drugs are used for treatment of
    syphilis except:-
    1. Doxycycline
    2. Benzathene penicillin
    3. Clindamycin
    4. Erythromycin

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18. Drug regimen for pancibacillary leprosy include:-
    1. Rifampicin
    2. Dapsone
    3. Clofazimine

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    4. Both (a) and (b)
19. Interaction between erythromycin and terfenadine
    can cause:-
    1. Torsades de pointes
    2. CNS stimulation

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    3. Fever
    4. Jaundice
20. Which of the following drug is useful in the medical
    management of Benign hypertrophy of prostrate:
    1. Nifedipinex

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    2. Clonidine ACA
    3. Estrogen
    4. Finasteride

SECTION-II

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Note :-
Attempt ALL questions. Write legible and
precise answers:-

(Max. Marks=80)

1. 1. Give a broad classification of Antimicrobial
      

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      agents(AMAs) on the basis of mechanism of
      action.
      (5)
   2. Discuss in brief therapeutic uses, ADR's and
      drug interactions of macrolide AMA's (15)

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2. A postgraduate student working in a medicine ward
   accidently got injured with a needle used for
   determination of blood glucose via glucometer in a
   55 years old female patient. A needle had deeply
   

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   penetrated across his gloves and skin. On evaluation
   of the patient, it has been found that patient is
   HIV+ve and not taking any kind of anti-retroviral
   therapy.
   1. Write one prefered drug regimen for
      post exposure prophyaxis.
      

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      (5)
   2. When should post exposure
      prophylactic medication be started?(2)
   3. What is pre exposure prophylaxis? (3)

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3. Write short notes on:- (4×5=20)
   1. Second generation H, antihistaminics.
   2. Therapeutic uses of Benzodiazipines.
   3. Mechanism of action and ADR's of combined
      oral contraceptic pills.
   4. Management of narrow angle glaucoma.

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4. Discuss in brief :- (4×5=20)
   1. Pharmacotherapy of bipolar mood disorder
   2. Mechanism of action and therapeutic uses of
      pioglitazone.
   3. Role of β-blockers in thyrotoxicosis.

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   4. Therapeutic uses and ADR's of morphine
5. Comment on the rationality of following
   statements:- (5×2=10)
   1. Methotrexate is beneficial in patients
      suffering from Rheumatoid arthritis.

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   2. Rifampicin and oral contraceptives should not
      be given together.
   3. d- penicillamine is given in Wilson's disease.
   4. N-acetyl cysteine is administered in
      paracetamol poisoning.

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   5. Sumatriptan is the preferred drug in acute
      severe migraine.

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