Rajiv Gandhi University of Health Sciences, Karnataka
Fourth Semester B. Pharm Degree Examination — 07-Jan-2020
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Time: Three Hours Max. Marks: 75 Marks
MEDICINAL CHEMISTRY -1
Q.P. CODE: 5014
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.
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LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
- Define and classify sedatives and hypnotics giving examples with one structure from each class. Discuss the SAR of benzodiazepines.
- Define and classify general anesthetics with examples. Explain their mode of action. Write the synthesis of methohexital sodium.
- a) What are adrenergic blockers? Classify alpha and beta adrenergic blockers with one structure from each class.
b) Write the synthesis and uses of Tolazoline and Propranolol.
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SHORT ESSAYS (Answer any Seven) 7 x 5 = 35 Marks
- Define and classify NSAIDs with example. Give the structure of one drug from each class.
- Discuss the SAR of phenothiazine analogs used as tranquilizers.
- What are direct acting sympathomimetics? Write four structures and their uses. Outline the synthesis of any one.
- Explain the role of hydrogen bonding and protein binding on drug action.
- Explain the importance of optical and geometrical isomerism in relation to biological action of drugs.
- What is Phase - I metabolism? Explain reductive and hydrolytic metabolisms with examples.
- Write the mechanism of action of cholinesterase inhibitors. Give two structural examples each for reversible and irreversible type.
- Discuss the SAR of cholinergic agonists.
- Give an account on solanaceous-alkaloids with structural examples. Write the synthesis of Ipratropium bromide.
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SHORT ANSWERS (Answer All) 10 x 2 = 20 Marks
- Write a note on nicotinic receptors.
- Write the structure and uses of Pilocarpine and Pyridostigmine.
- Write the synthesis of Procyclidine hydrochloride.
- What are Narcotic antagonists? Give two examples with structure.
- Write a note on the role of ionization on drug action.
- Explain amino acid conjugation in phase-II metabolism.
- Write the structure and uses of Atenolol and Metoprolol.
- Write a note on mixed acting sympathomimetics.
- Write the structure and uses of Dicyclomine and Clidinium.
- Write the structure and uses of Haloperidol and Phenytoin.
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This download link is referred from the post: RGUHS B.Pharm 4th Year 2020 Previous Question Papers - Rajiv Gandhi University of Health Sciences
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