Download RGUHS B.Pharm 2020 4th Year-Final Year Medicinal Chemistry II Rs 4 Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) Bachelor of Pharmacy (B.Pharm) 2020 4th Year-Final Year Medicinal Chemistry II Rs 4 Previous Question Paper

Rajiv Gandhi University of Health Sciences, Karnataka
IV Year B. Pharm Degree Examination - 20-Jan-2020
Time: 3 Hours





Max. Marks: 70 Marks
MEDICINAL CHEMISTRY - II
(RS ? 4)
QP Code: 2644
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.
LONG ESSAYS (Answer any Two)
2 X 10 = 20 Marks
1. Define antibiotics? Write a note on lactamase inhibitors. Explain the SAR & Mechanism of action of
tetracyclines
2. Classify antihypertensive agents? Write a note on Antianginal agents? Give the structure and uses
of any two nitro vasodilators.
3. What are anti arrhythmic drugs? Classify them with examples. Write structure and uses of
verapamil, phenytoin and propranolol.
SHORT ESSAYS (Answer any Six)
6 X 5 = 30 Marks
4. What are antitubercular agents? Write short notes on combination therapy for tuberculosis.
5. Give the examples of substituted Imidazoles as antifugal agents? Give the synthesis of Miconazole.
6. Classify sulfonamides based on site of action? Give the synthesis of Trimethoprim.
7. Give the mechanism and synthesis of chloroquine phosphate.
8. What are anticancer drug? Give the mechanism of action of alkylating agents.
9. Write any two structure and uses of the following.
i)Calcium channel blocker ii) Antihyperlipidemic agents
10. Discuss the chemistry of quinolines. Write the synthesis of Nitrofurantoin.
11. Write synthesis of chlorambucil and methotrexate.
SHORT ANSWERS
10 X 2 = 20 Marks
12. Mention the steric paramaters used in QSAR.
13. Give the structures of two carrier linked prodrugs.
14. Write are anthelmintics? Give examples.
15. What are antiprotozoal agents? Give the structure of carbasone.
16. Give source, structure and uses of quinine.
17. Write the structure and uses of alpha1 antagonist.
18. Define hypoglycemia. Name any two sulfonyl urea derivatives.
19. Give the structure of any two antithyroid drugs.
20. Structure and uses of Acetazolamide
21. Mechanism of action of thiazide diuretics
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