Download RGUHS B.Pharm 2020 4th Year-Final Year 2623 Pharmacy Practice II Rs 3 A. Pharmacokinetics And Therapeutic Drug Monitoring Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) Bachelor of Pharmacy (B.Pharm) 2020 4th Year-Final Year 2623 Pharmacy Practice II Rs 3 A. Pharmacokinetics And Therapeutic Drug Monitoring Previous Question Paper

Rajiv Gandhi University of Health Sciences, Karnataka
IV Year B.Pharm Degree Examination - 17-Jan-2020
Time: Three Hours





Max. Marks: 70 Marks
PHARMACY PRACTICE ? II (RS-3)
a. Pharmacokinetics and Therapeutic Drug Monitoring
Q.P. CODE: 2623
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any Two)
2 x 10 = 20 Marks
1.
Discuss the Pharmacokinetics of a drug given by IV bolus injection, which follows two
compartment open model.
2.
Discuss the Kinetics of protein binding. Explain the method for determination of binding
constant and number of binding sites.
3.
Discuss Multiple dosage regimen concept for Calculation of Cmax, Cmin and Css.
SHORT ESSAYS (Answer any Six)
6 x 5 = 30 Marks
4.
Discuss apparent volume of distribution. Explain the significance of high and low Vd.
5.
Explain various types of Pharmacokinetic models with their advantages and disadvantages.
6.
Describe clearance of drugs and its calculation.
7.
Discuss the functions of TDM services.
8.
Explain the significance of protein binding.
9.
Explain analytical aspects of TDM.
10. Describe drug distribution.
11. Discuss Dosing of drug in pregnancy & lactation.
SHORT ANSWERS
10 x 2 = 20 Marks
12. Microconstants in two compartment open model.
13. Pharmacokinetics.
14. Elimination rate constant.
15. Absorption rate constant.
16. Clearance.
17. Three compartment model.
18. Need for therapeutic drug monitoring of aminoglycosides.
19. Physiological modeling.
20. AUC
21. AUMC and MRT.
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