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Rajiv Gandhi University of Health Sciences, Karnataka
IV Year B.Pharm Degree Examination - 17-Jan-2020
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Time: Three Hours Max. Marks: 70 Marks
PHARMACY PRACTICE – II (RS-3)
a. Pharmacokinetics and Therapeutic Drug Monitoring
Q.P. CODE: 2623
Your answers should be specific to the questions asked
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Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
- Discuss the Pharmacokinetics of a drug given by IV bolus injection, which follows two compartment open model.
- Discuss the Kinetics of protein binding. Explain the method for determination of binding constant and number of binding sites.
- Discuss Multiple dosage regimen concept for Calculation of Cmax, Cmin and Css.
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SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks
- Discuss apparent volume of distribution. Explain the significance of high and low Vd.
- Explain various types of Pharmacokinetic models with their advantages and disadvantages.
- Describe clearance of drugs and its calculation.
- Discuss the functions of TDM services.
- Explain the significance of protein binding.
- Explain analytical aspects of TDM.
- Describe drug distribution.
- Discuss Dosing of drug in pregnancy & lactation.
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SHORT ANSWERS 10 x 2 = 20 Marks
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- Microconstants in two compartment open model.
- Pharmacokinetics.
- Elimination rate constant.
- Absorption rate constant.
- Clearance.
- Three compartment model.
- Need for therapeutic drug monitoring of aminoglycosides.
- Physiological modeling.
- AUC
- AUMC and MRT.
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