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[LA 817] APRIL 2012 Sub. Code: 3817
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
THIRD YEAR
PAPER V ? MEDICINAL CHEMISTRY
Q.P. Code: 383817
Time: Three Hours
Maximum: 100 marks
Answer ALL questions in the same orde
I. Elaborate on :
Pages Time Marks
(Max.) (Max.) (Max.)
1. Write the classification of Antibiotics and explain in detail 17 40 min. 20
the chemistry of Pencillins with mechanism of action and
examples. Explain on Macrolides and Aminoglycosides.
2. Discuss on Quantitative structure activity relationship with
17 40 min. 20
a note on various parameters. Write on the concept of
antisense molecules.
II. Write notes on :
1. Write the chemistry, structures and synthesis of any one
drug under the category of antifungal agents.
4 10 min. 6
2. Discuss on oral hypoglycemic agents.
4 10 min. 6
3. Brief out on thiazides and loop diuretics.
4 10 min. 6
4. Write on Mechanism of action, toxicity and uses of Sulphonamides. 4 10 min. 6
5. Brief out on combinatorial chemistry.
4 10 min. 6
6. Classify 1st line and 2nd line anti tubercular agents along
with structures from various classes.
4 10 min. 6
7. Give a short account on steroidal sex hormones.
4 10 min. 6
8. Write on calcium channel blockers.
4 10 min. 6
9. Discuss on angiotensin converting enzyme inhibitors and
aldosterone inhibitors as antihypertensives.
4 10 min. 6
10. Write on the prodrug concept and its applications.
4 10 min. 6
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