Download Pharm D 3rd Year 2012 April 383817 Medicinal Chemistry Question Paper

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[LA 817] APRIL 2012 Sub. Code: 3817

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DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION

THIRD YEAR

PAPER V - MEDICINAL CHEMISTRY

O.P. Code: 383817

Time: Three Hours Maximum: 100 marks

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Answer ALL questions in the same order

I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)

1. Write the classification of Antibiotics and explain in detail the chemistry of Pencillins with mechanism of action and examples. Explain on Macrolides and Aminoglycosides. (17 Pages, 40 min, 20 Marks)
2. Discuss on Quantitative structure activity relationship with a note on various parameters. Write on the concept of antisense molecules. (17 Pages, 40 min, 20 Marks)

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II. Write notes on :

1. Write the chemistry, structures and synthesis of any one drug under the category of antifungal agents. (4 Pages, 10min, 6 Marks)
2. Discuss on oral hypoglycemic agents. (4 Pages, 10min, 6 Marks)
3. Brief out on thiazides and loop diuretics. (4 Pages, 10min, 6 Marks)
4. Write on Mechanism of action, toxicity and uses of Sulphonamides. (4 Pages, 10 min, 6 Marks)

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5. Brief out on combinatorial chemistry. (4 Pages, 10min, 6 Marks)
6. Classify 1^st line and 2^nd line anti tubercular agents along with structures from various classes. (4 Pages, 10min, 6 Marks)
7. Give a short account on steroidal sex hormones. (4 Pages, 10min, 6 Marks)
8. Write on calcium channel blockers. (4 Pages, 10min, 6 Marks)
9. Discuss on angiotensin converting enzyme inhibitors and aldosterone inhibitors as antihypertensives. (4 Pages, 10min, 6 Marks)

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10. Write on the prodrug concept and its applications. (4 Pages, 10min, 6 Marks)