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[LB 813] OCTOBER 2012 Sub. Code: 3813
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
THIRD YEAR
PAPER I ? PHARMACOLOGY - II
Q.P. Code: 383813
Time: Three Hours
Maximum: 100 marks
Answer ALL questions in the same orde
I. Elaborate on :
Pages Time Marks
(Max.) (Max.) (Max.)
1. a) Classify anti-neoplastic agents with examples.
17 40 min. 20
b) Write the mechanism of action, therapeutic uses of
methotrexate.
c) Discuss in detail about general toxicity of cytotoxic agents.
2. Define Protein. Discuss the mechanism and various
17 40 min. 20
steps involved in Protein synthesis.
II. Write notes on :
1. Give the category, mechanism of action and side effects
of Tacrolimus.
4 10 min. 6
2. Write a note on Mutation.
4 10 min. 6
3. Give the mechanism of action and side effects of co-trimoxazole. 4 10 min. 6
4. Give the therapeutic uses and mechanism of actions
of metronidazole and pyrimethamine.
4 10 min. 6
5. Write the therapeutic uses of ciprofloxacin.
4 10 min. 6
6. Write a note on Heparin antagonist.
4 10 min. 6
7. Write a note on haematinics.
4 10 min. 6
8. Classify diuretics with suitable example.
Give the therapeutic uses of thiazide diuretics.
4 10 min. 6
9. Write the mechanism of actions:
4 10 min. 6
(i) Acetazolamide (ii) Vasopressin (iii) Rifampicin.
10. Briefly explain (i) Translocation (ii) Tumour suppressor gene. 4 10 min. 6
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