Download Pharm D 4th Year 2009 September 383823 Biopharmaceutics And Pharmacokinetics Question Paper

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[KV 823] SEPTEMBER 2009 Sub. Code: 3823

DOCTOR OF PHARMACY (PHARM. D / POST BACCALAUREATE)

DEGREE EXAMINATION

(Regulations 2008-2009 )

(Candidates admitted from 2008-2009 onwards)

FOURTH YEAR

PAPER V ? BIOPHARMACEUTICS AND PHARMACOKINETICS

Q.P. Code: 383823

Time: Three Hours











Maximum: 70 marks

Answer ALL questions

I. Elaborate on:

















(2 x 20 = 40)

1. Elaborate on the pharmacokinetic model and equations in one compartment

open model I.V. bolus.

2. a) Define bio-equivalence.

List the various methods involved in the determination of bio-equivalence.

b) Elaborate on any one delivery system for estimation of bioequivalence.

II. Write notes on:











(6 x 5 = 30)

1. Physiological barrier to drug distribution.

2. Causes of non-linearity with example.

3. Mean residence time.

4. Limitations of multi compartmental analysis.

5. Renal impairment and creatinine clearance.

6. A drug has to be administered as a continuous I.V. infusion so as to reach a

study state concentration of 0.5mcg/ml. What should be the infusion rate if

it is following the one compartment model? (T?=8 hr. and V=13L)



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