Pharm D Last 12 Years 2010-2022 Question Papers (1st Year, 2nd Year, 3rd Year, 4th Year and 5th Year)
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[KV 823] SEPTEMBER 2009 Sub. Code: 3823
DOCTOR OF PHARMACY (PHARM. D / POST BACCALAUREATE) DEGREE EXAMINATION
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(Regulations 2008-2009 )
(Candidates admitted from 2008-2009 onwards)
FOURTH YEAR
PAPER V - BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. Code: 383823
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Time: Three Hours Maximum: 70 marks
Answer ALL questions
- Elaborate on: (2x20=40)
- Elaborate on the pharmacokinetic model and equations in one compartment open model I.V. bolus.
- a) Define bio-equivalence. List the various methods involved in the determination of bio-equivalence.
b) Elaborate on any one delivery system for estimation of bioequivalence.
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- Write notes on: (6x5=30)
- Physiological barrier to drug distribution.
- Causes of non-linearity with example.
- Mean residence time.
- Limitations of multi compartmental analysis.
- Renal impairment and creatinine clearance.
- A drug has to be administered as a continuous I.V. infusion so as to reach a study state concentration of 0.5mcg/ml. What should be the infusion rate if it is following the one compartment model? (T½=8 hr. and Vd=13L)
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