Download Pharm D 5th Year 2022 January 383827 Clinical Pharmacokinetics and Pharmacotherapeutic Drug Monitoring Question Paper

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[PHARMD 0122] JANUARY 2022 Sub. Code: 3827

(OCTOBER 2021 EXAM SESSION)



PHARM `D' AND PHARM. `D' (POST BACCALAUREATE) DEGREE EXAMINATION

FIFTH YEAR (2009-2010 Regulation)

PAPER III ? CLINICAL PHARMACOKINETICS AND

PHARMACOTHERAPEUTIC DRUG MONITORING

Q.P. Code : 383827


Time : Three hours

Answer ALL Questions Maximum : 70 Marks


I. Elaborate on:

(4 x 10 = 40)



1. Describe about Bayes estimator and applications.

2. Explain in detail about conversion from intravenous to oral dosing of drugs.

3. Elaborate on Pharmacokinetic drug interactions with suitable example.

4. Enumerate inhibition and induction of drug metabolism.

II. Write notes on:



(6 x 5 = 30)



1. TDM of drugs used in organ transplantations.

2. Measurement of GFR and creatinine clearance.

3. Explain Dosage adjustment in Uremic patients.

4. Enumerate effect of hepatic disease on pharmacokinetics.
5. An aminoglycoside has a normal elimination half-life of 107 minutes in young

adults. In patients 70 to 90 years old, the elimination half-life of the
aminoglycoside is 282 minutes. The normal dose of the aminoglycoside is 15
mg/kg per day divided into two doses. What is the dose for a 75-year-oId patient,
assuming that the volume of distribution per body weight is not changed by the
patient's age?

6. Dosing in Obese patients.

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