24-05-2025
II-MBBS
Second M.B.B.S. (Supp) Exam (New
Scheme)
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May-2025PHARMACOLOGY
Paper- 1
Time: Three Hours Maximum Marks: 100
Attempt all questions in both sections
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Use separate answer book for each section01211A1+01211A2
Section-A
Fill in the blanks:
6x1=6 marks
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a. The drug of choice in anaphylactic shock is__________
b. The irreversible non-selective COX inhibitor is
__________
c. The antidote for benzodiazepine poisoning is
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__________
d. Neostigmine is an example of a __________
acting anticholinesterase.
e. The antidote for paracetamol poisoning is
__________
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f. The volume of distribution is __________ inlipid-soluble drugs.
Multiple Choice Questions (MCQs)
4x1=4 marks
1. Drug causing "first-dose
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phenomenon" is:A. Atenolol
B. Prazosin
C. Propranolol
D. Nifedipine
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2. Bioavailability of a drug administeredintravenously is:
A. 0%
B. 50%
C. 100%
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D. Depends on metabolism3. Which drug causes gingival hyperplasia?
A. Phenytom
B. Diazepam
C. Atropine
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D. Digoxin4. Drug that acts as a competitive antagonist of
acetylcholine at NMJ:
A. Succinylcholine
B. Atracurium
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C. PhysostigmineD. Pilocarpine
Clinical Case Study
5x3=15 marks
A 60-year-old hypertensive patient comes to the
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emergency with bradycardia, low BP, and ahistory of beta-blocker use.
Answer the following:
a. What could be the possible cause of this
presentation?
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b. Name two probable drugs responsible.c. What is the antidote for beta-blocker
overdose?
d. How do beta-blockers decrease blood
pressure?
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e. What precautions should be taken whileprescribing beta-blockers in diabetic
patients?
Write short notes on the following (Any Five)
5x2=10 marks
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a. Bioavailabilityb. Enzyme inhibition
c. Adverse effects of atropine
d. Drug synergism
e. Therapeutic drug monitoring
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f. Therapeutic index
Explain briefly - Any three
3 x 5=15 marks
1. Selective Cox 2 Inhibitors
2. Diffusion hypoxia
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3. Malignant hyperthermia and its management.4. Mechanism of action of local anesthetics
Section-B
A 28-year-old man is brought
4 x 5=20 marks
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into the emergency department after beingfound unresponsive. He is lethargic and
unresponsive verbally. He has been given 25%
of Dextrose intravenously without result: On
examination, his heart rate is 60 beats per
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minute, and respiratory rate is 8 per minute andRA shallow. His pupils are pinpoint and not
reactive. There are multiple intravenous track
marks on his arms bilaterally. The emergency
physician concludes that the patient has had a
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drug overdose.Answer the following questions:
a. Which drug is likely responsible for the
patient's condition.
b. Describe the mechanism of action of this
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drug.c. How will you manage of the patient.
d. Write 2 antagonists for this drug with salient
features.
Write short notes on ANY FIVE 5 x 2=10 marks
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a. Therapeutic uses of benzodiazepines.b. Mechanism of action of Ondansetron
c. Therapeutic uses of Dantrolene
d. Adverse drug reactions of Phenytoin
e. Extrapyramidal effects of chlorpromazine
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f. Therapeutic uses of NSAID's.Explain briefly - ANY FOUR
4x5=20 marks
a. Informed consent
b. H1 receptor blockers: classification and uses
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c. Use of antiepileptic drugs in pregnancy.d. Selective serotonin reuptake inhibitors
(SSRIs)
e. Pharmacovigilance
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