II-MBBS
(This paper consists of 03 pages)
01221A1+01221A2
Second M.B.B.S. (Supp) Exam. (New
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Scheme)May-2025
PATHOLOGY
Paper-1
Time: Three Hours
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Maximum Marks: 100Attempt all questions in both sections
(Use separate answer book for each section)
Section-A
Q.1 Fill in the blanks [6x1=06]
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a. Tissue composed of macrophages,capillaries and fibroblasts is called
__________
b. Thalassemia gives protection against
_________
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c. Starry sky appearance in lymph node isseen in ________
d. Major fibril protein in primary amyloidosis is
________
e. Packed RBC's (PRBC's) are stored at
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_________f. Diagnostic feature of granuloma is presence
of _________
Q.2 Answer the followings (Multiple choice
questions) [4x1=04]
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i. A pathologist notes cloudy swelling, hydropicchange in kidney and fatty change in the liver
of a patient with a history of alcohol abuse.
These morphological changes are all
examples of
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A. Early neoplastic changeB. Hyaline change
C. myxoid change
D. Reversible cell injury
ii. Most probable diagnosis in a 25-year-old
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lady on treatment for rheumatoid arthritis withlab investigations as follows: Hb- 9gm/dl;
MCV- 55ff; Serum Iron-30 microgram/dl;
Serum Ferritin- 200ng/mL, TIBC-298
microgram/dl is
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A. Iron deficiency anemia
B. Thalassemia Major
C. Anemia of chronic disorder
D. Megaloblastic anemia
iii. A 43-year-old man has complained of mild
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burning (substernal) pain following meals forthe past 3 years. Upper Gl endoscopy is
performed and biopsies are taken of any
erythematous area of the lower esophageal
mucosa 3 cm above the gastroesophageal
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junction. There is no mass- lesion, noulceration, and no hemorrhage noted. The
biopsies show the presence of columnar
epithelium with goblet cells Which of the
following mucosal alterations is most likely
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represented by these findings?A. Ischaemia
B. Metaplasia
C. Dysplasia
D. Hyperplasia
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iv. Chromosomal translocation seen in CML:A. t(9:22)
B. t(8;14)
C. t (2;8)
D. t (15;17)
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Q.3 [15]
A 24-year-old female presented to the
emergency room with complaints of fever,
excessive bruising, and bleeding from her gums
for the past two weeks. She also reported
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feeling unusually fatigued and noticed small redspots on her skin. On examination, she was
febrile with pale skin, notable ecchymosis, and
gingival bleeding. Laboratory results revealed a
WBC count of 19,000/?l, hemoglobin of 8.2
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g/dl, and platelet count of 30,000/?l. The WBCdifferential showed 19% lymphocytes, 8%
monocytes, and 73% atypical cells. The
peripheral blood smear indicated the presence
of atypical hypergranular cells with
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creased/folded nuclei and multiple cytoplasmicneedle-like inclusions. Coagulation studies were
significant for a prolonged prothrombin time
(PT) of 19.5 sec, low fibrinogen of 62 mg/dL,
and prolonged partial thromboplastin time
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(PTT) of 57.4 sec. D-dimer was 10,880 ng/ml.(normal <500 ng/mL).
a. Based on the history and lab findings, what
is your diagnosis? [2]
b. What genetic abnormality is typically
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associated with this condition [2]c. What are needle like inclusions in the
atypical cells [2]
d. Identify the coagulation abnormality based
on the above parameters [3]
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e. Explain the pathophysiological mechanismof coagulation disorder of this patient [4]
f. Enumerate the two morphological variants of
this condition [2]
Q.4 Write short notes on (Any five): [5x2=10]
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a. Leukemoid reactionb. Down's syndrome
c. Opportunistic lung infection in AIDS
d. Ghons' complex
e. Paraneoplastic syndrome
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Q.5 Explain briefly (Any three): [3x5=15]a. Laboratory diagnosis of hemolytic anemia
b. Amyloid stains
c. Mechanism of Apoptosis
d. Pathological calcification
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Section-B
Q.6 [20]
Define thrombosis, write in detail about the
pathogenesis, causes, morphology and fate of
thrombus
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Q.7 Write short notes on (Any five): [5x2=10]a. Gaucher's disease
b. Mechanism of cellular aging
c. Enumerate examples of granulomatous
inflammation
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d. Phases of CMLe. Reticulocyte
f. Importance of blood grouping
Q.8 Explain briefly (Any four): [4x5=20]
a. Type I hypersensitivity reaction
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b. Mechanism of metastasisc. Immune thrombocytopenic purpura
d. Mention the need of collaborative work in
health care and state the hurdles in the same.
e. Pathophysiology of B thalassemia major
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***Document Outline
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