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Rajiv Gandhi University of Health Sciences, Karnataka
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III Year Pharm-D Degree Examination – 10-Jan-2020
MEDICINAL CHEMISTRY (RS & RS2)
Q.P. CODE: 2865
Time: Three Hours
Max. Marks: 70 Marks
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Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
LONG ESSAYS (answer any two) 2 x 10 = 20 Marks
- What are Beta lactam antibiotics? Give the degradation products of penicillins. Outline the synthesis of Chloramphenicol
- Classify antihypertensive agents? Write a note on antianginal agents? Give the structure and uses of any two nitro vasodilators
- a) What is crystal urea? How to overcome from it. b) How is malaria caused? Classify antimalarial agents.
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SHORT ESSAYS (answer any six) 6 x 5 = 30 Marks
- Give examples of drugs that act as DNA polymerase inhibitors. Describe their chemistry and therapeutic uses
- What are anti TB drugs? Enlist the problems associated with the treatment. Give the structure of Para amino salicylic acid and INH
- Add a note on folate reductase inhibitors. Explain the synergistic action of Sulphamethoxazole and Trimethoprim
- Write the SAR of i) 8-amino quinolines ii) 4-amino quinolines
- Give the structure, MOA and therapeutic uses of Chlorambucil
- Write briefly about the chemistry and MOA of anticoagulants
- Give the examples of substituted Imidazoles as antifungal agents? Give the synthesis of Miconazole.
- Name any four antiamoebic drugs. Give the synthesis of Metronidazole.
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SHORT ANSWERS 10 x 2 = 20 Marks
- What is CADD? Enlist the applications
- Write the structure of one prodrug and its active metabolites
- Name any two calcium channel blockers with their uses
- Define hyperglycemia? Name any two biguanides used in the treatment of diabetes
- Give the MOA of biguanides
- What are antithyroid drugs? Why are they called goitrogens?
- Structure and uses of Furosemide
- What are potassium sparing diuretics? Give examples
- Name any two drugs used for examination of liver function
- What are steroidal drugs? Name any two steroidal drugs with their uses
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