Rajiv Gandhi University of Health Sciences, Karnataka
IV Year Pharm-D (I Year Pharm D Post Baccalaureate) / IV Year Pharm-D (Post Baccalaureate) Degree Examination – 14-Jan-2020
Time: Three Hours Max. Marks: 70 Marks
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BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. CODE: 2871 / 2888
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary.
LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
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- Define drug distribution. Describe the factors affecting distribution.
- Discuss in detail two compartment open model for a drug administered as IV Bolus. Give the schematic representation, graphs and equations for the same.
- Define bioavailability and mention the objectives of bioavailability studies. Explain the various methods of enhancement of bioavailability.
SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks
- What do you understand by gastric emptying and discuss factors affecting the same.
- Explain the assumptions of one-compartment open model.
- What is biotransformation and explain its importance?
- Explain statistical moment theory.
- What do you mean by non-linear pharmacokinetics and write brief note on factors causing non-linearity.
- Define and explain pharmacokinetic models and mention its significance.
- Discuss Michaelis - Menton equation.
- Explain phase I reactions.
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SHORT ANSWERS 10 x 2 = 20 Marks
- Give the formula for AUC determination.
- Define dosing frequency.
- Mention the significance of protein binding.
- What is Total body clearance?
- What is accumulation index?
- List out the various drug transport mechanisms.
- Explain principle of plateau or steady state.
- What is renal clearance? Give its formula.
- How do solvates and hydrates affect drug absorption?
- Define biological half life.
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