- What are drug transporters and discuss the impact of genetic variations in drug transporters?
- Explain the applications of metabolomics and genomics in pharmacogenomics.
- Explain the GPCR signaling pathway and write their significance.
- What is gene sequencing and genomic mapping? Explain the Maxam and Gilbert method of gene sequencing in detail.
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SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
- Explain the factors affecting the genetic variation in drug transporters.
- Write a note on Restriction enzymes in recombinant DNA technology.
- Explain intrinsic and extrinsic pathway of apoptosis.
- Explain the media requirements and techniques of cell culture.
- Discuss the basic principle and applications of calcium influx assays.
- Write the importance of siRNA and micro RNA.
- Discuss the principle and applications of cell viability assay.
- Explain the role of cyclic AMP signaling pathway with example.
- Explain the structure and functions of Microtubules and Microfilaments.
- Explain the role of immunotherapeutics in clinical pharmacology.
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