RGUHS M.Pharm 2nd Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences
I » FirstRanker's choice - Draw labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three)
Marks
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- What is a lead molecule? Discuss the various stages involved in identification of a lead molecule.
- What are antihypertensive agents? Classify with examples. Write a note on ACE inhibitors.
- Explain the rational design of non-covalently and covalently binding enzyme inhibitors.
- Write a note on rationale of prodrug design and its practical considerations.
SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
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- Write a note on genetic principles of drug resistance.
- Outline the biosynthetic pathway of thromboxanes.
- Write a note on beta blockers with examples and give the synthesis of Propranolol.
- Explain the design of stereo isomers and geometric isomers with respect to analog design of drugs.
- Write a note on H1 receptor antagonists. Write the synthesis of any one H1 receptor antagonist.
- Define Peptidomimetics? Explain its medicinal importance.
- Outline the design of Peptidomimetics by modification of the peptide backbone.
- Write the application of enzyme inhibitors in designing of therapeutic agents.
- Write a note on enantio selectivity in drug absorption and metabolism.
- Write a note on high throughput screening and its applications.
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