Download RGUHS M.Pharm 2nd Year 2020 5179 Principles Of Drug Discovery Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharm (Master of Pharmacy) 2nd Year (2nd Semester) 2020 5179 Principles Of Drug Discovery Previous Question Paper

Rajiv Gandhi University of Health Sciences, Karnataka
Second Semester M. Pharm Degree Examination - 16-Jan-2020
Time: Three Hours
Max. Marks: 75 Marks
PRINCIPLES OF DRUG DISCOVERY
Q.P. CODE: 5179
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three)
3 X 10 = 30 Marks
1.
Enumerate target identification and target validation in drug discovery.
2.
What are the types of molecular docking? Explain any two-docking based screening
method.
3.
Explain the methods involved in traditional drug design.
4.
Explain the different virtual screening techniques in drug discovery.
SHORT ESSAY (Answer any Nine)
9 X 5 = 45 Marks
5.
Explain the role of molecular modeling in drug design.
6.
Describe the rational of prodrug design.
7.
Write a note on De-nova drug design.
8.
Explain the role of nucleic acid microarray in target drug discovery.
9.
Write a note on statistical methods used in QSAR analysis.
10. Discuss the concepts of rational drug design.
11. Explain about role of transgenic animals in target validation.
12. Explain about the levels of protein structure.
13. Explain about rigid docking in molecular modeling.
14. Write a note on 3D-QSAR.
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