Download VNSGU (Veer Narmad South Gujarat University or South Gujarat University) MBBS ?(Bachelor of Medicine, Bachelor of Surgery) 1st Year 2021 January Biochemistry Paper I Previous Question Paper
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1st MBBS Examination
January - 2021
Biochemistry -Paper-1
(New CBME Pattern)
k|Q"p : / Instructions
(1)
"uQ? v$ip?h?g r"ip"uhpmu rhNsp? D?fhlu `f Ah?e gMhu.
Seat No.:
Fill up strictly the details of signs on your answer book
Name of the Examination:
1st MBBS
Name of the Subject :
Biochemistry -Paper-1 (New CBME Pattern)
Subject Code No.: 2006000101030001
Student's Signature
Section A: MCQ
(20 Marks)
Instructions:
1. All questions are compulsory
2. Each MCQ has only one correct answer
3. One mark for correct answer. No negative marking
4. If more than one answer is ticked, it will be treated as wrong answer
5. Any tempering with answer will be treated as wrong answer
6. Use only ball point black pen. Pencil is strictly prohibited
7. Correct answer must be marked on OMR sheet with black pen & submit in
first30minutes
1.
Which of the following is not a reducing sugar?
a) Lactose
b) Maltose
c) Sucrose
d) Fructose
2.
Spermatozoainseminalfluidutilizesthefollowingsugarforitsmetabolism
a) Galactose
b) Glucose
c) Fructose
d) Mannose
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3
Rancidity of butter is prevented by addition of
a) Vitamin D
b)
Tocopherols
c) Biotin
d) Copper
4
Irreversible steps of Glycolysis are catalyzed by:
a) Hexokinase, Phosphofructokinase, Pyruvate Kinase
b) Glucokinase, Pyruvate Kinase, Glyceraldehyde 3 Phosphate
Dehydrogenase
c) Hexokinase, Phospho Glycerate Kinase, Pyruvate Kinase
d) Pyruvate Kinase, Fructose 1,6 Bisphosphatase, Phosphofructokinase
5
Peripheral neuropathy occurs due to accumulation of which of the
following sugar?
a) Sorbitol
b) Mannitol
c) Ribitol
d) Glycerol
6
Fatty acid oxidation does takes place in
a) Cytoplasm
b)
Mitochondria
c) Golgi apparatus
d)
Endoplasmic reticulum
7
Obesitygenerallyreflectsexcessintakeofenergyandisoftenassociated
with the development of
a) Nervousness
b) Non-insulin dependent diabetes mellitus
c) Colon cancer
d) Mood elevation
8
Which of the following cytochrome is involved in biotransformation of
xenobiotics?
a) Cytochrome c
b)
Cytochrome b
c) Cytochrome P
d)
Cytochrome al
450
9
SDA of food is highest for:
a) Carbohydrates
b) Fats
c) Iron
d) Proteins
10
RegardingHMPshuntallofthefollowingaretrue,EXCEPT
a) Occurs in cytosol
b) No ATP produced
c) Active in adipose tissue, liver, lactating mammary gland, adrenal gland
d) Oxidative phase generates NADPH and non oxidative phase generates
pyruvate
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11
Which of the following carbohydrate is used to measure glomerular
filtrationrate?
a) Inulin
b) Chitin
c) Dextran
d) Sucrose
12
All are true about HbA 1 c, except
a) Fasting sample is not required
b) Gives status of long-term glucose control
c) Samplemustbecollectedinfluoridebulb
d) HbAlc more than 9% indicates poor control
13
Bloodurealevelishighinall,EXCEPT
a) Renal failure
b) Dehydration
c) Hepatic failure
d) Prostate hypertrophy
14
BMR is decreased in
a) Cold climate
b)
During exercise
c) Age 4 to 6 years
d)
Hypothyroidism
15
Hemolyzed sample is not suitable for estimation of which parameter?
a) Sodium
b) Potassium
c) Chloride
d) Calcium
16
Increased H+, decreased HCO ? and decreased pCO are seen in
3
2
a) Metabolic acidosis
b)
Metabolic alkalosis
c) Respiratory acidosis
d)
Respiratory alkalosis
17
Thepredominantcationofintracellularfluidis
a) K+
b) Na+
c) Mg2+
d)
Ca2+
18
Whichofthefollowingstatement(s)aboutdietaryfiberis/aretrue
a) Fibers helps in reducing risk of colon cancer
b) Fiber lowers serum cholesterol levels
c) Promotes the normal motility of the gut and prevents constipation
d) All of the above
19
Chronic alcoholism poses a risk of
a) Lactic acidosis
b) Hepatic cirrhosis
c) Wernicke-Korsakoff syndrome
d) All of the above
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20
Whichofthefollowingdietarymeasure(s)is/areconsideredas
`cardio protective'?
a) Consuming large quantities of PUFA
b) RestrictingSFAtolessthan10%oftotalcalorieintake
c) Addingmorefibertodiet
d) All of the above
Instructions : for section B & C:
1.Useblue/blackballpointpenonly.
2. The numbers to the right indicates full marks.
3. Draw diagrams wherever necessary
Section
B:
(40
Marks)
Q 2:
Long Answer Questions (ANY TWO)
(2 ? 10 = 20)
a) Enumerate functions of Cholesterol. Describe the synthesis of
cholesterol. Add a note-on its regulation. What are other fate of acetyl
CoA(2+4+2+2=10)marks).
b) What is gluconeogenesis? What is the importance of gluconeogenesis?
Name the substrate used for gluconeogenesis. Describe the pathways of
gluconeogenesis Name disease/condition in which gluconeogenesis is
significantlyenhanced(1+2+1+5+1=10marks).
c) Describe the dietary sources, absorption, daily requirement, biochemical
functions and disorders of calcium metabolism. Add a note on regulation
serumcalciumlevel(1+2+1+2+1+3=10marks).
Q 3:
Brief Answer Questions (ANY TEN)
(10 ? 2 = 20)
a) Biochemical basis of respiratory distress syndrome in newborns.
b) Defineglycemicindexandstateitsimportance.
c) What is glycated hemoglobin? Write its normal range and clinical
significance.
d) Lactose intolerance
e) Biochemical basis of Wilson disease
f) Lysosomes are called suicidal bags, justify.
g) Functions of iron.
h) Metabolic acidosis
i) Describethebiomedicalimportanceofdietaryfibres
j) Essential fatty acids: names, biochemical basis of essentiality,
functionsanddeficiencymanifestations,
k) Writeanytworeactionsofdetoxificationbyconjugation.
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Section C
Q 4:
Short answer questions (ANY FOUR)
(4 ? 5 = 20)
a) Discuss essential elements of communication in medical encounters.
Construct a plan for effective patient-doctor communication (3+2 Marks).
b) Classify phospholipids with example. Enumerate the functions of
phospholipids. (2+3 Marks)
c) Renal function tests
d) Glycogen storage disorders.
e) Harmful effects of free radicals on biomolecule and diseases associated
with it.
Q 5:
Clinical Cases (ALL COMPULSORY)
(2 ? 10 = 20)
Case 1:
15 year unconscious boy was brought by his parents in hospital. He had
tachypnia (increase respiratory rate) & fruity smell from breath. Sign of
dehydration was present. In blood investigation, his blood glucose level
found450mg%andmetabolicacidosisseeninABG.
a) What is a diagnostic criterion for diagnosis of DM based on plasma
glucose concentration (WHO criteria)?
b) What is reason for fruity smell in breath, tachypnia and dehydration?
c) Why uncontrolled diabetes mellitus leads to ketosis?
d) Write various causes of metabolic acidosis?
e) Write acute and chronic complication of non insulin dependent Diabetes
mellitus.
Case 2:
1) A 35 year old pregnant woman from poor family came with complain of
weakness breathlessness and early fatigue. On examination she was pale;
herHbwas7.0gm%andperipheralsmearshowedhypochromicmicrocytic
RBCs.
a) What are dietary sources of iron?
b) Write RDA of Iron in adults.
c) Enlist the factors affecting absorption of Iron. What is role of
vitamin C in iron absorption?
d) Functions of iron (any four).
e) Iron is called one-way element. Explain.
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This post was last modified on 28 December 2021