Download DNB 2015 Dec PHARMA P III Question Paper

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FINAL EXAM

NATIONAL BOARD OF EXAMINATIONS

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PHARMA/D/15/34/11

DECEMBER 2015

PHARMACOLOGY

PAPER - lll

Time : 3 hours

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Max. Marks : 100

Important instructions:

• Attempt all questions in order.
• Each question carries 10 marks.
• Read the question carefully and answer to the point neatly and legibly.

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• Do not leave any blank pages between two answers.
• Indicate the question number correctly for the answer in the margin space.
• Answer all the parts of a single question together.
• Start the answer to a question on a fresh page or leave adequate space between two answers.
• Draw table/diagrams/flowcharts wherever appropriate.

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Write short notes on:

1. Physiological role, pharmacological function and clinical use of Vitamin-D. (2+4+4)

2. Mechanism of action, route of administration, adverse effect & precaution of infliximab use in inflammatory bowel disease. (3+2+3+2)

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3. Mechanism of action, therapeutic uses, adverse effects and clinical status of sitagliptin in management of diabetes mellitus. (3+2+2+3)

4. Etiopathogenesis, management and recent advances for treatment of Alzheimer’s disease (AD). (3+4+3)

5. What are drug-drug and Drug-food interactions? Describe physiological, pharmacokinetic and pharmacodynamic factors responsible for drug-drug and drug Food interactions mentioning suitable examples. (2+8)

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6. a) Pathophysiology and management of supra-ventricular tachycardia. (2+5)

   b) Limitations of amiodarone as antiarrhythmic agent. (3)

7. Uses, advantages and adverse effects of Selective Serotonin Re-uptake inhibitor (SSRIs). (3+4+3)

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8. a) Current approaches in the management of metabolic syndrome. (5)

   b) Mechanism of action and adverse effects of metformin. (3+2)

9. a) Classify general anesthetic agents. (2)

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   b) Mechanism of action, therapeutic uses, adverse effects and precautions of propofol. (2+2+2+2)

10. a) Type I and type II error (5)

    b) Student ‘t’ test (2)

    c) ANOVA test (3)

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POSSESSION / USE OF CELL PHONE IS NOT PERMITTED INSIDE THE EXAMINATION HALL.