Download DNB 2015 Dec MEDICAL ONCOLOGY I Question Paper

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FINAL EXAM

NATIONAL BOARD OF EXAMINATIONS

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MED.ONCO/D/15/1711

DECEMBER 2015

MEDICAL ONCOLOGY

PAPER — I

Time : 3 hours

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Max. Marks : 100

Important instructions:

• Attempt all questions in order.
• Each question carries 10 marks.
• Read the question carefully and answer to the point neatly and legibly.

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• Do not leave any blank pages between two answers.
• Indicate the question number correctly for the answer in the margin space.
• Answer all the parts of a single question together.
• Start the answer to a question on a fresh page or leave adequate space between two answers.
• Draw table/diagrams/flowcharts wherever appropriate.

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Write short notes on:

1. Various immune check point inhibitors and potential biomarkers to monitor their efficacy. Name 4 cancers where role of immunotherapy appears to be promising. (8+2)
2. a) Enumerate the antibiotic antineoplastic agents. (2+4+4)
   b) Mechanism of resistance.
   c) Side effects of these drugs.

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3. Role of tumor markers in diagnosis and prognosis of solid cancers. (5+5)
4. A 3 year old child has presented with right orbital mass of 3 months duration. Briefly discuss the differential diagnosis, work up plan, also briefly suggest treatment outline for each of the probable diagnosis. (4+3+3)
5. a) What are the hallmarks of cancer? (5+(3+2))
   b) Role of anti angiogenic agents in cancer ovary and renal cell cancer.
6. A 62 year old gentlemen was treated with radical radiation for his T4 glottic cancer. What will be the radiation fields, dose and long term toxicity expected? Discuss the options of salvage treatment in case his disease recurs after 2 years.

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7. a) Mechanism of histone deacetylase inhibitors. (4+(3+3))
   b) Illustrate your answer with example of myelodysplastic syndrome and multiple myeloma.
8. Write principles of micro-array technology. What are the different types and its usage? (5+5)
9. a) Staging, pathology and molecular biology of endometrial cancer. (3+3+2)+2
   b) Outline its impact on management.

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10. a) Different types of clinical trials. (5+5)
    b) Plan a clinical trial for advanced lung cancer in elderly population.

POSSESSION / USE OF CELL PHONES IS NOT PERMITTED INSIDE THE HALL.