Download DNB 2015 Dec MICROBIOLOGY I Question Paper

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FINAL EXAM

DECEMBER 2015

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MICROBIOLOGY

PAPER — I

Time : 3 hours

Max. Marks : 100

Important instructions:

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• Attempt all questions in order.
• Each question carries 10 marks.
• Read the question carefully and answer to the point neatly and legibly.
• Do not leave any blank pages between two answers.
• Indicate the question number correctly for the answer in the margin space.

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• Answer all the parts of a single question together.
• Start the answer to a question on a fresh page or leave adequate space between two answers.
• Draw table/diagrams/flowcharts wherever appropriate.

NATIONAL BOARD OF EXAMINATIONS

MICRO/D/15/18/1

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Write short notes on:

1. a) Principle and technique of plasma sterilization. 6+4
   b) What are its applications?
2. a) Define Minimum Inhibitory Concentration (MIC). 1+3+(2+2+2)
   b) List the various techniques of determining MIC of a bacterial strain.
   

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   c) Write their principles, advantages and disadvantages.
3. Principle, technique and uses of Pulsed-Field-Gel-electrophoresis. 3+4+3
4. Principle, technique and applications of Real Time- PCR. 2+6+2
5. List various Enzyme Immuno Assays (EIA). Describe them with suitable examples. 3+7
6. a) Mechanism of action of carbapenem antibiotics. 4+(2+4)
   

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   b) Its scope of antibacterial activity and their resistance mechanisms.
7. a) Define “Pathogenicity Islands”. 2+8
   b) Its role in bacterial pathogenesis with suitable examples.
8. Principle, uses and procedure of gene therapy. 2+4+4
9. a) What is “In-Use Test”? 2+(2+6)
   

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   b) Its procedure and application in hospital.
10. a) What are antigen presenting cells (APCs)? 2+3+5
    b) Enumerate the different types of APCs.
    c) Mechanisms involved in antigen processing by various APCs.

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