Download DNB 2015 Dec BIOCHEMISTRY II Question Paper

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FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2015
BIOCHEMISTRY
PAPER - II
BIO/D/15/03/11

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Important instructions:

• Attempt all questions in order.
• Each question carries 10 marks.

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• Read the question carefully and answer to the point neatly and legibly.
• Do not leave any blank pages between two answers.
• Indicate the question number correctly for the answer in the margin space.
• Answer all the parts of a single question together.
• Start the answer to a question on a fresh page or leave adequate space between two answers.

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• Draw table/diagrams/flowcharts wherever appropriate.

1. Write short notes on:
   1. Classify lipoprotein and state their characteristics. (5+5)
   2. List the functions of Poly Unsaturated Fatty Acids (PUFA).
2. Describe the role of vitamin K. What are good sources of this vitamin? List deficiency manifestations and explain the biochemical basis for these. (2+2+6)

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3. 1. Clinical significance of copper. (2+(4+4))
   2. Two genetic disorders of copper metabolism in reference to defective genes and copper metabolism.
4. What are different types of Glycogen storage diseases? Explain why a patient with Von-Gierke’s disease presents with hyperuricemia. (5+5)
5. 1. Explain Folate trap. (4+(3+3))

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   2. Role of folic acid and vitamin-B12 in megaloblastic and pernicious anemia, respectively.
6. 1. Classify hormones on the basis of their mechanism of action. (4+6)
   2. Write about the hormones that are transported by plasma proteins.

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7. 1. Transamination reaction. (2+4+4)
   2. Chemiosmotic theory of oxidative phosphorylation.
   3. TCA cycle as a metabolic hub.
8. Write major metabolic fates of pyruvate and acetyl CoA in mammals. (4+6)
   

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   Describe various adaptive changes if fasting is prolonged to the state of starvation.
9. 1. Define reactive oxygen species. (2+8)
   2. Role of anti-oxidant vitamins in prevention of oxidative damage.
10. What is meant by protein energy malnutrition (PEM)? What are the types of PEM? Briefly describe the clinical and biochemical features of each type. (2+2+6)

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POSSESSION / USE OF CELL PHONES IS NOT PERMITTED INSIDE THE EXAMINATION HALL.