Download B.Pharm 1st Year 2012 February 564252 Pharmaceutical Organic Chemistry Question Paper

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February 2012

[LA 4252] Sub. Code: 4252

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FIRST B.PHARM. EXAMINATION

Paper I - PHARMACEUTICAL ORGANIC CHEMISTRY

Q.P. Code : 564252

Time: Three Hours Maximum: 100 marks

Answer ALL questions

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1. I. Elaborate on: (2x20=40)

   1. (a) Give the structure nomenclature, preparation and reaction of Cycloalkanes.(10)
      (b) Add a note on addition reactions of conjugated dienes. (5)
      (c) Explain the formation of bonding, anti-bonding orbitals. (5)
   2. (a) What is kekule structure of benzene and write their resonance structure of Benzene. (7)
      

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      (b) Explain the SN1 reaction with the help of a suitable example. (8)
      (c) Outline the test for purity, preparation and medicinal uses of saccharin. (5)

2. II. Write notes on: (8 x5=40)

   1. What is the diazonium reaction? Explain the general reaction?

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   2. Write the synthesis and properties of phenanthrene.
   3. Explain keto-enol tautomerism with examples.
   4. Write the preparation, test for purity and medicinal uses of benzoic acid
   5. Explain the Bayer’s strain theory and its limitations.
   6. Give the nomenclature and reactions of alkynes.

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   7. Explain the markovnikov’s rule including the mechanism and with an example.
   8. What are Grignard reagent and explain with one example?

3. III. Short Answers (10x 2=20)

   1. Define intermolecular bonding.

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   2. Write the structure and uses of citric acid
   3. How will you test the purity of vanillin?
   4. Define hyper conjugation.
   5. What is energy of activation?
   6. Explain the following reactions
      1. Sandmeyer reaction

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      2. Gattermann reaction.
   7. What is Dienes?
   8. What are alkyl halides?
   9. Write the preparation of malonic ester

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   10. Explain bond fission.

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