Download B.Pharm 2nd Year 2018 February 564258 Advanced Pharmaceutical Organic Chemistry Question Paper

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B.PHARM. DEGREE EXAMINATION

SECOND YEAR

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PAPER III - ADVANCED PHARMACEUTICAL ORGANIC CHEMISTRY

Time: Three hours Maximum: 100 Marks

I. Elaborate on: (2x20=40)

1. Explain the following reactions as synthetic tools:
   1. Oxidation with lead tetra acetate and periodic acid
   2. Beckmann rearrangement and Schmidt rearrangement.

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2. 1. Define and classify terpenoids with example.
   2. Write the chemistry of alpha terpineol.

II. Write notes on: (8x5=40)

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1. Explain the various elements of symmetry with example.
2. Explain the chemistry of caffeine.
3. Discuss on tetrahedral carbon atom and stereochemistry of cyclic compounds.
4. Explain the sequence rules relating the R & S configuration.
5. Describe the common method of isolation of alkaloids.

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6. Write the electrophilic reaction of pyrrole.
7. Explain the chemistry of Vitamin A.
8. Discuss the pharmacological activity of atropine and related alkaloids.

III. Short answers on: (10x2=20)

1. What is clemmenson’s reduction?

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2. Define Stereomutation.
3. Mention the medicinal uses of Vitamin B6 and B12.
4. Write the difference between enantiomer and diastereomer.
5. Give any two important reactions of isoxazole.
6. What is Walden inversion?

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7. Define glycosides and name any two glycosides.
8. Write the structure and uses of papaverine.
9. Give the structure and uses of menthol and thymol.
10. Write the structural difference between theophylline and theobromine.

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