BPHARM 0921] SEPTEMBER 2021 Sub. Code: 4258
(FEBRUARY 2021 EXAM SESSION)
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B. PHARMACY DEGREE EXAMINATION
SECOND YEAR - (NON-SEMESTER)
PAPER III - ADVANCED PHARMACEUTICAL ORGANIC CHEMISTRY
O.P. Code: 564258
Time: Three hours Answer ALL Questions Maximum: 100 Marks
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I. Elaborate on: (2x20=40)
- What are Purines? Elucidate the structure of Uric acid. Differentiate between caffeine, theophylline and theobromine.
- Explain the mechanism and applications of
- Birch reduction
- Meerwein Ponndorf reduction.
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II. Write notes on: (8 x5=40)
- Explain the chemistry of Vitamin E.
- Give reasons for the following:
- Explain why the electrophilic substitution reactions of Pyrrole predominantly occur at 2nd position than 3rd position.
- Explain why Pyrrole and Furan is more reactive than Thiophene.
- What is resolution of Racemic modification? Explain the method of resolution by biochemical separation.
- Define optical activity. What are the various optical isomers possible in compounds containing two different chiral carbons?
- Explain Fischer Indole synthesis.
- Explain Cahn Ingold and Prelog system for assigning configuration based on sequence rules.
- Explain the chemistry and pharmacological actions of Digitoxin.
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III. Short answers on: (10x 2=20)
- What is Darzen’s reaction?
- Distinguish between Enantiomers and Diasteromers.
- Why nitrobenzene is mostly used as oxidizing agent in Skraup synthesis.
- Mention two uses of Lithium aluminum hydride.
- Give two methods for the synthesis of Imidazole.
- Write any two reactions of Furan.
- What is Fischer projection?
- Explain briefly D and L system of nomenclature.
- Write the structure and use of Atropine.
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This download link is referred from the post: B.Pharm 3rd Year Last 12 Years 2010-2022 Previous Question Papers (Bachelor of Pharmacy)
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