Download B.Pharm 3rd Year 2011 August 564262 Medicinal Chemistry I Question Paper

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[KZ 4262] Sub. Code : 4262

THIRD B.PHARM. EXAMINATION

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Paper III - MEDICINAL CHEMISTRY - I

Q.P. Code : 564262

Time : Three hours Maximum: 100 Marks

Answer ALL questions.

I. LONG ESSAYS (2 x 20 = 40)

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1. a) What are adrenergic neurotransmitters explain their function with example. (2+8)
   b) Derive the biosynthesis and metabolism of catecholamines. (5+5)
2. Explain the following physiochemical parameters related to biological activity with Example. (4 x 5 = 20)
   a) Bioisosterism b) Hydrogen bonding c) Geometrical Isomerism d) Chelation.

II. SHORT NOTES (8 x 5 = 40)

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1. Application of Prodrug Design.
2. Classify General Anaesthetics with example. Give any one synthesis.
3. Give the Structural Activity Relationship of Thiazide Diuretics.
4. Add a note on COX-1 and COX-2 Inhibitors with mechanism.
5. Classify sedative and Hypnotics with example.

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6. Define and classify Antitussive Agents with example.
7. Define Antipsychotics. Give the synthesis for chlorpromazine hydrochloride.
8. Give the synthesis for the following: a) Chlorthiazide. b) Terbutaline.

III. SHORT ANSWERS (10 x 2 = 20)

Give the Structure and Medicinal uses for the following:

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1. Halothane.
2. Diazepam.
3. Nikethamide.
4. Atenolol.
5. Benzocaine.

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Define the following Terms:

1. Redox potential.
2. Xenobiotics.
3. MAO Inhibitors.
4. Tranquilliser

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5. Local Anaesthetics.

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