Download B.Pharm 3rd Year 2011 August 564262 Medicinal Chemistry I Question Paper

Download B.Pharmacy (Bachelor of Pharmacy) 3rd Year (Third Year) 2011 August 564262 Medicinal Chemistry I Previous Question Paper

August 2011

[KZ 4262]















Sub. Code : 4262

THIRD B.PHARM. EXAMINATION

Paper II ? MEDICINAL CHEMISTRY - I

Q.P. Code : 564262

Time : Three hours











Maximum: 100 Marks

Answer ALL questions.

I. LONG ESSAYS















(2 x 20 = 40)

1. a) What are adrenergic neurotransmitters explain their function with example. (2+8)

b) Derive the biosynthesis and metabolism of catecholamines. (5+5)

2. Explain the following physiochemical parameters related to biological activity

with Example. (4 x 5 = 20)

a) BioIsosterism b) Hydrogen bonding c) Geometrical Isomerism d) Chelation.

II. SHORT NOTES















(8 x 5 = 40)

1. Application of Prodrug Design.

2. Classify General Anaesthetics with example. Give any one synthesis.

3. Give the Structural Activity Relationship of Tiazide Diuretics.

4. Add a note on COX-1 and COX-2 Inhibitors with mechanism.

5. Classify sedative and Hypnotics with example.

6. Define and classify Antitussive Agents with example.

7. Define Antipsychotics. Give the synthesis for chloropromazine hydrochloride.

8. Give the synthesis for the following: a) Chlorthiazide. b) Terbutaline.

III. SHORT ANSWERS









(10 x 2 = 20)

Give the Structure and Medicinal uses for the following:

1. Halothane.

2. Diazepam.

3. Nikethamide.

4. Atenalol.

5. Benzocaine.

Define the following Terms:

6. Redox pontential.

7. Xenobiotics.

8. MAO Inhibitors.

9. Tranquillise

10. Local Anaesthetics.

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