Download B.Pharm 3rd Year 2012 August 564262 Medicinal Chemistry I Question Paper

Download B.Pharmacy (Bachelor of Pharmacy) 3rd Year (Third Year) 2012 August 564262 Medicinal Chemistry I Previous Question Paper


[LB 4262]

AUGUST 2012



Sub. Code: 4262

THIRD YEAR B.PHARM. EXAM

Paper II ? MEDICINAL CHEMISTRY - I

Q.P. Code: 564262

Time : Three hours









Maximum: 100 Marks

(180 Min) Answer ALL questions in the same orde

I. Elaborate on:

Pages Time Marks

(Max.)(Max.)(Max.)

1. a) What are antihistamines? Classify them with examples. 19

33

20

Explain the structure activity relationship of antihistamines.



b) Write the synthetic pathway for i) Diphenhydramine HCl
ii) Tripelenamine HCl iii) Promethazine HCl.









2. Explain in detail about Phase-II metabolic reactions

with suitable examples.

19

33

20



II. Write notes on:



1. Describe the Drug-Receptor Interactions.

3

8

5

2. Write the structure activity relationship of Benzodiazepine.3

8

5

3. Write the synthesis for a) Carbamazepine b) Valproic aci 3

8

5

4. Write a note on Cholinesterase Inhibitors.

3

8

5

5. What is the Mechanism of action of NSAIDs? Give

the synthesis for any one NSAIDs.

3

8

5

6. What are Diuretics? Classify them with examples.

3

8

5

7. Write a note on General Anaesthetics.

3

8

5

8. Elucidate the prostaglandin synthesis from

Arachidonic aci

3 8 5


III. Short Answers:

1. Structure and uses of Nikethamide.

1

5

2

2. Synthesis of Atenolol.

1

5

2

3. Briefly on Opiod Antagonists.

1

5

2

4. Define Local Anaesthetics with Mechanism of action.

1

5

2

5. Write the structures for a) Ketamine b) Thiopental sodium. 1

5

2

6. Define prodrug with example.

1

5

2

7. Surface activity on Biological action.

1

5

2

8. Synthesis of Salbutamol.

1

5

2

9. Define Neurotransmitter and give examples.

1

5

2

10. Structure and uses of Mecamylamine

HCl.

1 5 2



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