B.Pharm 3rd Year Last 12 Years 2010-2022 Previous Question Papers (Bachelor of Pharmacy)
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[LB 4262] AUGUST 2012 Sub. Code: 4262
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THIRD YEAR B.PHARM. EXAM
Paper I - MEDICINAL CHEMISTRY -1
Q.P. Code: 564262
Time : Three hours Maximum: 100 Marks
(180 Min) Answer ALL questions in the same order
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I. Elaborate on:
| Pages (Max.) | Time (Max.) | Marks (Max.) | |
|---|---|---|---|
| 1. a) What are antihistamines? Classify them with examples. Explain the structure activity relationship of antihistamines. b) Write the synthetic pathway for 1) Diphenhydramine HCI i1) Tripelenamine HCI iii) Promethazine HCI. | 19 | 33 | 20 |
| 2. Explain in detail about Phase-II metabolic reactions with suitable examples. | 19 | 33 | 20 |
II. Write notes on:
- Describe the Drug-Receptor Interactions.
- Write the structure activity relationship of Benzodiazepine.
- Write the synthesis for a) Carbamazepine b) Valproic acid
- Write a note on Cholinesterase Inhibitors.
- What is the Mechanism of action of NSAIDs? Give the synthesis for any one NSAIDs.
- What are Diuretics? Classify them with examples.
- Write a note on General Anaesthetics.
- Elucidate the prostaglandin synthesis from Arachidonic acid
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| 3 | 8 | 5 | |
| 3 | 8 | 5 | |
| 3 | 8 | 5 | |
| 3 | 8 | 5 | |
| 3 | 8 | 5 | |
| 3 | 8 | 5 | |
| 3 | 8 | 5 | |
| 3 | 8 | 5 |
III. Short Answers:
- Structure and uses of Nikethamide.
- Synthesis of Atenolol.
- Briefly on Opiod Antagonists.
- Define Local Anaesthetics with Mechanism of action.
- Write the structures for a) Ketamine b) Thiopental sodium.
- Define prodrug with example.
- Surface activity on Biological action.
- Synthesis of Salbutamol.
- Define Neurotransmitter and give examples.
- Structure and uses of Mecamylamine HCI.
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