Download B.Pharm 3rd Year 2021 September 564262 Medicinal Chemistry I Question Paper

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[BPHARM 0921] SEPTEMBER 2021 Sub. Code: 4262

(FEBRUARY 2021 EXAM SESSION)

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B. PHARMACY DEGREE EXAMINATION

THIRD YEAR - (NON-SEMESTER)

PAPER II - MEDICINAL CHEMISTRY -1

Q.P. Code: 564262

Time: Three hours Answer ALL questions Maximum: 100 Marks

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I. Elaborate on: (2x20=40)

1. a) What are anticonvulsants? Classify it with examples.(5)
   b) Write the synthesis for the following drugs.(10)
   1) Triclofos Sodium ii) Diazepam iii) Chlorpromazine.HCL iv) Valproic Acid
   c) Describe the Structure Activity Relationship of Benzodiazepines.(5)

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2. a) Explain the following physiochemical parameters related to biological activity with example.
   1) Bioisosterism ii) Protein binding iii) Ionisation iv) Drug-Receptor interaction.

II. Write notes on: (8 x5=40)

1. Classify Diuretics with suitable examples.
2. Synthesis of Procaine and Dibucaine.

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3. SAR of Tricyclic antidepressants.
4. Name some cholinergic blocking agents and write synthesis of Tropicamide.
5. Write the Synthetic route of Furosemide and Amiloride.
6. Add a note on COX 1 and COX II inhibitors with mechanism.
7. Give some reactions of Phase 1 Metabolism.

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8. Explain the theories of Drug-Receptor interaction.

III. Short answers on: (10x2=20)

1. Signal transduction.
2. Structure and use of Mecamylamine Hcl.
3. Reaction product of Malonic ester and urea.

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4. Write synthetic route of Ketamine Hcl.
5. Give the structure of any two anti-ulcer drugs.
6. Define Drug Latentiation.
7. SAR of Barbital.
8. Write about Eicosanoids.

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9. Explain Neuromuscular blockers.
10. Write the synthesis of Promethazine Hcl.

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