AUGUST 2014
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Sub. Code: 4270
FOURTH YEAR B.PHARM. DEGREE EXAMINATION
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Paper IV - MODERN METHODS OF PHARMACEUTICAL ANALYSISQ. P. Code: 564270
Time: Three Hours
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Maximum: 100 Marks
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Answer All Questions
I. Essay Questions:
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(2 x 20 = 40)
1. a) Write the principle, preparation, procedure and method of detection
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in Column chromatography.b) What is the different carrier gases used in gas chromatography and
what are the ideal requirements of the carrier gas. Also give
the application of gas chromatography.
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2. a) Give the principle, theory instrumentation of mass spectrometer and
application of mass spectroscopy.
b) Describe the principle and instrumentation involved in Flame emission
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spectroscopy.II. Short Notes:
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(8 x 5 = 40)
1. Describe with neat diagram the working principles of nepheloturbidimete
2. Explain the different types of detection technique used in paper chromatography.
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3. Explain the current voltage curve and various currents in polarographicmeasurements.
4. Explain amperometric titrations of curves with example.
5. What is principle and procedure for ultra-centrifuge?
6. Explain shielding, de-shielding and spin coupling in NMR spectroscopy.
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7. Describe the parameters of analytical method validation.8. Write on Radioimmunoassay.
III. Short Answers:
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(10 x 2 = 20)1. Define Chromophores and Auxochromes.
2. Explain photoelectric colorimete
3. What is Rf value and retention volume?
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4. Explain the term quenching.5. What is finger print region?
6. Draw the conductometric titration curve for a strong acid vs a mixture of
strong and weak base.
7. Give bragg's equation in x-ray diffraction technique.
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8. What are polarographicsupressors?9. What is function of filter and monochromator?
10. Explain electrochemical cell.
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