Download B.Pharm 4th Year 2016 February 564270 Modern Methods of Pharmaceutical Analysis Question Paper

(LI 4270)

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FEBRUARY 2016



Sub. Code: 4270

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FOURTH YEAR B.PHARM. EXAMINATION

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PAPER IV ? MODERN METHODS OF PHARMACEUTICAL

ANALYSIS

Q.P. Code: 564270

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Time: Three hours

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Maximum: 100 Marks

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I. Essay:

(2 x 20 = 40)

1. a) Write the principle, instrumentation and applications of UV-Vis

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Spectrophotometry.

2. a) Explain the principles and applications of AAS.

b) Explain the working principle and instrumentation of fluorimetry with a neat

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labeled diagram.


II. Short notes:

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(8 x 5 = 40)

1. Explain the construction and working of Hydrogen electrode.
2. Write a note on ultracentrifugation.
3. Explain briefly the preparation & activation of TLC plates.

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4. List the various detectors used in HPLC. Explain in detail the working principle of

UV detector with a neat labeled diagram.

5. Write a note on Electron Spin Resonance spectroscopy.

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6. Write short notes on conductometric titrations.
7. Describe the instrumentation of NMR with a neat diagram.
8. Write a note on sample handling in IR spectroscopy.

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III. Short answers:

(10 x 2 = 20)

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1. What is Retention time and Rf value?
2. Define isocratic & gradient elution.
3. Write any two advantages of Amperometric titrations.
4. Write Nernst equation. What is its significance?
5. Define migration current.

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6. Define fluorescence.
7. Define hypso chromic and hyper chromic shift.
8. Write any two applications of Nephelo-turbidimetry.
9. List various types of cation and anion exchangers.
10. Define Base peak.

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