Download B.Pharmacy (Bachelor of Pharmacy) 4th Year (Final Year) 2012 August 564270 Modern Methods of Pharmaceutical Analysis Previous Question Paper
(LB 4270)
AUGUST 2012
Sub. Code: 4270
FOURTH YEAR B.PHARM. EXAM
PAPER IV ? MODERN METHODS OF PHARMACEUTICAL ANALYSIS
Q.P. Code: 564270
Time: Three Hours
Maximum: 100 marks
(180 Min) Answer ALL questions in the same orde
I. Elaborate on:
Pages Time Marks
(Max.)(Max.)(Max.)
1. (a) Define Chemical Shift. Explain the factors affecting
chemical shift.
(b) Write the principle, working procedure, types and
applications of Radio Immuno Assay.
19
33
20
2. (a) Write the theory, apparatus, working and applications
of Polarography.
(b) Define electrophoresis. Explain in detail about Gel
electrophoresis and Capillary electrophoresis.
19
33
20
II. Write notes on:
1. Write a note on ultracentrifugation.
3
8
5
2. Explain the types of columns used in High Performance
Liquid Chromatography.
3
8
5
3. What are the types of ion exchange resins used in ion
exchange chromatography? Explain.
3
8
5
4. Write the identification and quantification procedures
involved in the separation of individual components
from mixture by Thin Layer
Chromatography.
3 8 5
5. Write the principle involved in the separation of amino
acids by Paper Chromatography. Explain the reaction of
amino acid with Ninhydrin reagent.
3
8
5
6. Write the principle, instrumentation and applications of
Nephalometry.
3 8 5
7. Explain the sampling techniques for solids in IR
Spectrophotometry.
3 8 5
8. How will you calculate max by Woodward ?Fischer rule?3
8
5
III. Short Answers:
1. Bathochromic shift and Hypsochromic
shift.
1 5 2
2. Relationship between concentration and fluorescence
intensity.
1 5 2
3. Hallow Cathode Lamp.
1
5
2
4. Reverse Phase Chromatography.
1
5
2
5. Junction
potential.
1 5 2
6. Equivalent Conductance and Molecular
conductance. 1 5 2
7. Spin ? Spin Coupling.
1
5
2
8. Molecular ion peak.
1
5
2
9. Capacity facto
1 5 2
10. Nernst ? Glowe
1
5
2
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