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(LP 4270)
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AUGUST 2019 Sub. Code: 4270
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B.PHARM. DEGREE EXAMINATIONFOURTH YEAR
PAPER IV ? MODERN METHODS OF PHARMACEUTICAL
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ANALYSIS
Q.P. Code: 564270
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Time: Three hours--- Content provided by FirstRanker.com ---
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Maximum: 100 MarksI. Elaborate on:
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(2 x 20 = 40)
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1. a) Write in detail about the principle and instrumentation of HPLC with a neatdiagram.
b) Write about the various types of curves in conductometric titrations.
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2. a) Explain about the principle and instrumentation of fluorimeteb) Explain the factors affecting the fluorescence intensity.
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II. Write notes on:(8 x 5 = 40)
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1. Derive an equation for Beer-Lamberts Law.
2. Explain the reaction of amino acid with Ninhydrin reagent in paper
chromatography.
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3. Sources used in IR Spectroscopy.
4. What are the types of ion exchange resins used in Ion exchange chromatography?
5. Write a note on the preparation and activation of TLC plates.
6. Short note on coupling constant.
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7. Write notes on GLP.8. Potentiometric titrations.
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III. Short answers on:(10 x 2 = 20)
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1. Explain Bathochromic shift and Hypsochromic shift.
2. Ilkovic equation.
3. Define quenching.
4. What is Junction potential?
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5. Define the term retention time, retention volume.6. Define Parent peak.
7. Define validation.
8. Give the range of I Spectrum.
9. What is edge effect?
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10. Write different techniques in X-ray diffraction.*******
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