Download B.Pharm 4th Year 2019 August 564270 Modern Methods of Pharmaceutical Analysis Question Paper

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(LP 4270)

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AUGUST 2019 Sub. Code: 4270

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B.PHARM. DEGREE EXAMINATION

FOURTH YEAR

PAPER IV ? MODERN METHODS OF PHARMACEUTICAL

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ANALYSIS

Q.P. Code: 564270

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Time: Three hours

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Maximum: 100 Marks



I. Elaborate on:

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(2 x 20 = 40)

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1. a) Write in detail about the principle and instrumentation of HPLC with a neat

diagram.
b) Write about the various types of curves in conductometric titrations.

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2. a) Explain about the principle and instrumentation of fluorimete

b) Explain the factors affecting the fluorescence intensity.

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II. Write notes on:

(8 x 5 = 40)

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1. Derive an equation for Beer-Lamberts Law.
2. Explain the reaction of amino acid with Ninhydrin reagent in paper

chromatography.

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3. Sources used in IR Spectroscopy.
4. What are the types of ion exchange resins used in Ion exchange chromatography?
5. Write a note on the preparation and activation of TLC plates.
6. Short note on coupling constant.

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7. Write notes on GLP.
8. Potentiometric titrations.

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III. Short answers on:

(10 x 2 = 20)

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1. Explain Bathochromic shift and Hypsochromic shift.
2. Ilkovic equation.
3. Define quenching.
4. What is Junction potential?

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5. Define the term retention time, retention volume.
6. Define Parent peak.
7. Define validation.
8. Give the range of I Spectrum.
9. What is edge effect?

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10. Write different techniques in X-ray diffraction.



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