(LR 4267)
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DECEMBER 2020 Sub. Code: 4267
(AUGUST 2020 SESSION)
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B.PHARM. DEGREE EXAMINATIONFOURTH YEAR
PAPER I ? FORMULATIVE PHARMACY AND BIO-PHARMACEUTICS
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Q.P. Code: 564267
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Time: Three hours--- Content provided by FirstRanker.com ---
Maximum: 100 Marks
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I. Elaborate on: (2 x 20 = 40)1. Write the benefits and limitations of prolonged action pharmaceuticals. Discuss
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the different types, construction and evaluation of prolonged actionpharmaceuticals.
2. Define Pharmacokinetics and discuss the compartment models. Write a note on the
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following.
(a) Biological half life. (b) Apparent Volume of Distribution
(c) Elimination rate constant (d) Renal clearance.
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II. Write notes on:(8 x 5 = 40)
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1. Mechanism of drug absorption.
2. Physicochemical properties of drug molecule.
3. Process of sugar coating.
4. Accelerated stability studies.
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5. Evaluation of Transdermal delivery systems.6. Procedure for bio-equivalency studies.
7. Film defects and rectification.
8. Evaluation of hard gelatin capsules.
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III. Short answers on:
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(10 x 2 = 20)
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1. Lubricant and glidant.2. Base absorption.
3. Hazing/ dull film.
4. Double impression.
5. Bio-pharmaceutics.
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6. Noyes Whitney equation.7. Dielectric constant.
8. Slugging.
9. Different type of tablets.
10. Film tensile strength.
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